Although rare, intraneural hemangiomas should be considered in the differential diagnosis of peripheral nerve lesions. We report on a 59-year-old female patient, who was admitted to the hospital due to the discovery o...Although rare, intraneural hemangiomas should be considered in the differential diagnosis of peripheral nerve lesions. We report on a 59-year-old female patient, who was admitted to the hospital due to the discovery of bilateral breast masses for 3 months, there was no paresthesia or dyskinesia. The patient accidentally found a mass in the right upper mediastinum while completing a plain chest X-ray, initially suspected as a benign neurilemmoma on CT. Surgical resection and pathological analysis confirmed an intraneural hemangioma. Unexpectedly, the patient developed new-onset right upper limb numbness and paresthesia 3 months post-operatively, probably related to surgical nerve injury. This case underscores the importance of maintaining a broad differential for mediastinal masses, and the potential for iatrogenic neurological complications when managing these rare, yet vascular lesions.展开更多
Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a label...Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between s展开更多
目的:评价脊神经脉冲射频联合腰椎间盘臭氧消融术治疗腰椎间盘突出症(LDH)的疗效及安全性。方法:选择80例LDH患者均分为脊神经脉冲射频联合腰椎间盘臭氧消融术组(治疗组)及腰椎间盘臭氧消融术组(对照组),两组患者于治疗前、术后第3天、...目的:评价脊神经脉冲射频联合腰椎间盘臭氧消融术治疗腰椎间盘突出症(LDH)的疗效及安全性。方法:选择80例LDH患者均分为脊神经脉冲射频联合腰椎间盘臭氧消融术组(治疗组)及腰椎间盘臭氧消融术组(对照组),两组患者于治疗前、术后第3天、第1月、第3月、第6月时采用数字评价量表评分(NRS)评估疼痛程度、Oswestry 功能障碍指数(ODI)评估腰椎功能、治疗6月时的治疗有效率及不良反应发生情况等。结果:治疗后各时间点与治疗前相比,两组LDH患者NRS评分和ODI评分均有降低,差异有统计学意义( P <0.05);治疗后不同时间点两组患者之间NRS评分和ODI评分均表现为治疗组患者低于对照组,差异有统计学意义( P <0.05);治疗组患者治疗后第6月的有效率高于对照组患者,差异有统计学意义( P <0.05);两组LDH患者术后不良反应发生率差异无统计学意义( P >0.05)。结论:脊神经脉冲射频联合腰椎间盘臭氧消融术提高腰椎间盘突出症疗效,且起效快、安全。展开更多
文摘目的:根据目前临床研究证据系统评价脊神经脉冲射频调节治疗腰椎源性疼痛的疗效及安全性。方法:计算机检索Cochrane图书馆、Pub Med、中国期刊全文数据库(CNKI)、万方等数据库,并辅以手工检索相关文献,收集相关临床随机对照研究。按照Cochrane系统评价方法评价纳入研究的质量,提取有效的数据用Rev Man 5.2软件及stata 12.0进行统计分析。结果:共纳入12项研究,1063例患者。Meta分析结果显示,脉冲射频治疗腰椎源性疼痛疗效明显优于普通镇痛组,治疗终点VAS评分差异有统计学意义;脉冲射频组与口服药物、神经阻滞治疗组治疗神经病理性疼痛在安全性方面相比有较显著优势。结论:脉冲射频治疗方法对于缓解腰椎源性疼痛具有较满意短期及长期疗效,且安全性较高。
文摘Although rare, intraneural hemangiomas should be considered in the differential diagnosis of peripheral nerve lesions. We report on a 59-year-old female patient, who was admitted to the hospital due to the discovery of bilateral breast masses for 3 months, there was no paresthesia or dyskinesia. The patient accidentally found a mass in the right upper mediastinum while completing a plain chest X-ray, initially suspected as a benign neurilemmoma on CT. Surgical resection and pathological analysis confirmed an intraneural hemangioma. Unexpectedly, the patient developed new-onset right upper limb numbness and paresthesia 3 months post-operatively, probably related to surgical nerve injury. This case underscores the importance of maintaining a broad differential for mediastinal masses, and the potential for iatrogenic neurological complications when managing these rare, yet vascular lesions.
基金supported by National Key Research&Development Program of China,No.2016YFC11011601,2017YFA0104701the Youth Cultivation Project of Military Medical Science,China,No.15QNP091(to YW)People’s Liberation Army Youth Training Project for Medical Science of China,No.16QNP144(to YW)
文摘Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between s
文摘目的:评价脊神经脉冲射频联合腰椎间盘臭氧消融术治疗腰椎间盘突出症(LDH)的疗效及安全性。方法:选择80例LDH患者均分为脊神经脉冲射频联合腰椎间盘臭氧消融术组(治疗组)及腰椎间盘臭氧消融术组(对照组),两组患者于治疗前、术后第3天、第1月、第3月、第6月时采用数字评价量表评分(NRS)评估疼痛程度、Oswestry 功能障碍指数(ODI)评估腰椎功能、治疗6月时的治疗有效率及不良反应发生情况等。结果:治疗后各时间点与治疗前相比,两组LDH患者NRS评分和ODI评分均有降低,差异有统计学意义( P <0.05);治疗后不同时间点两组患者之间NRS评分和ODI评分均表现为治疗组患者低于对照组,差异有统计学意义( P <0.05);治疗组患者治疗后第6月的有效率高于对照组患者,差异有统计学意义( P <0.05);两组LDH患者术后不良反应发生率差异无统计学意义( P >0.05)。结论:脊神经脉冲射频联合腰椎间盘臭氧消融术提高腰椎间盘突出症疗效,且起效快、安全。
