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Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety 被引量:77
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作者 Wei Wei Pei-En Jian +9 位作者 Shao-Hua Li Zhi-Xing Guo Yong-Fa Zhang Yi-Hong Ling Xiao-Jun Lin Li Xu Ming Shi Lie Zheng Min-Shan Chen Rong-Ping Guo 《Cancer Communications》 SCIE 2018年第1期655-666,共12页
Background:The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma(HCC)patients with solitary tumor and microvascular invasion(MVI)is controversial.This trial evaluated the effi... Background:The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma(HCC)patients with solitary tumor and microvascular invasion(MVI)is controversial.This trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization(TACE)after hepatectomy versus hepatectomy alone in HCC patients with a solitary tumor≥5 cm and MVI.Methods:In this randomized,open-labeled,phase III trial,HCC patients with a solitary tumor≥5 cm and MVI were randomly assigned(1:1)to receive either 1-2 cycles of adjuvant TACE after hepatectomy(Hepatectomy-TACE)or hepatectomy alone(Hepatectomy Alone).The primary endpoint was disease-free survival(DFS);the secondary end-points included overall survival(OS)and adverse events.Results:Between June 1,2009,and December 31,2012,250 patients were enrolled and randomly assigned to the Hepatectomy-TACE group(n=125)or the Hepatectomy Alone group(n=125).Clinicopathological characteristics were balanced between the two groups.The median follow-up time from randomization was 37.5 months[interquartile range 18.3-48.2 months].The median DFS was significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[17.45 months(95%confidence interval[CI]11.99-29.14)vs.9.27 months(95%CI 6.05-13.70),hazard ratio[HR]=0.70(95%CI 0.52-0.95),P=0.020],respectively.The median OS was also significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[44.29 months(95%CI 25.99-62.58)vs.22.37 months(95%CI 10.84-33.91),HR=0.68(95%CI 0.48-0.97),P=0.029].Treatment-related adverse events were more frequently observed in the Hepatectomy-TACE group,although these were generally mild and manageable.The most common grade 3 or 4 adverse events in both groups were neutropenia and liver dysfunction.Conclusion:Hepatectomy followed by adjuvant TACE is an appropriate option after radical resection in HCC patients with solitary tumor≥5 cm and MVI,with acceptable toxicity. 展开更多
关键词 solitary tumor Hepatocellular carcinoma Adjuvant therapy Transcatheter arterial chemoembolization Hepatectomy alone Microvascular invasion
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孤立性肺结节良恶性判断数学预测模型的建立 被引量:54
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作者 李运 陈克终 +9 位作者 隋锡朝 卜梁 周足力 杨帆 刘彦国 赵辉 李剑锋 刘军 姜冠潮 王俊 《北京大学学报(医学版)》 CAS CSCD 北大核心 2011年第3期450-454,共5页
目的:通过单因素和多因素分析筛选出与孤立性肺结节(solitary pulmonary nodules,SPN)恶性概率相关的临床资料,构建一种判断SPN良恶性的数学预测模型。方法:回顾性收集2000年1月至2009年9月在北京大学人民医院经手术切除并明确病理诊断... 目的:通过单因素和多因素分析筛选出与孤立性肺结节(solitary pulmonary nodules,SPN)恶性概率相关的临床资料,构建一种判断SPN良恶性的数学预测模型。方法:回顾性收集2000年1月至2009年9月在北京大学人民医院经手术切除并明确病理诊断的SPN患者资料共371例(A组),其中男197例、女174例。总结患者的年龄、性别、病程、症状、吸烟史及吸烟量、既往肿瘤史、肿瘤家族史、肿瘤部位、肿瘤最大径、肿瘤有无钙化、毛刺、分叶、胸膜牵拉征、边界清楚、血管集束征、空洞共17项临床资料,通过逻辑回归分析筛选与SPN病理性质相关的独立因素,构建数学预测模型。另外收集2009年10月至2010年5月期间切除并明确病理诊断的SPN患者资料共62例(B组)以验证本模型的临床预测价值。结果:A组371例SPN中良性142例(46.9%),229例恶性(53.1%)。单因素分析结果显示,患者年龄、吸烟史及吸烟量、肿瘤家族史、钙化、毛刺、分叶、胸膜牵拉征、边界以及肿瘤最大径在良、恶性SPN之间的差异有统计学意义。多因素Logistic回归分析结果显示,年龄、直径、肿瘤家族史、毛刺、钙化、边界清楚等6项因素在良性和恶性SPN之间的差异有统计学意义(P<0.05),是判断SPN性质的独立影响因素。建立的SPN良恶性预测数学方程为:SPN恶性预测值=ex/(1+ex),x=-4.496+(0.07×年龄)+(0.676×直径)+(0.736×毛刺)+(1.267×肿瘤家族史)-(1.615×钙化)-(1.408×边界),其中e为自然对数。选取截点T=0.463,利用B组数据验证该公式对SPN良、恶性判断的灵敏性为92.5%,特异性为81.8%,阳性预测值90.2%,阴性预测值85.7%。本组数学预测模型的受试者工作特征曲线下面积为0.888±0.054。结论:患者年龄、肿瘤最大径、肿瘤家族史、钙化、毛刺、边界是判断SPN良、恶性的独立相关因素,通过逻辑回归建立的数学预测模型的准确性较高,有较好的临床应用价值。 展开更多
关键词 孤立性肺结节 肿瘤 LOGISTIC模型 预测 诊断 鉴别
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TRAVELING WAVE SOLUTIONS FOR A CLASS OF NONLINEAR DISPERSIVE EQUATIONS 被引量:38
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作者 LIJIBIN LIUZHENGRONG 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2002年第3期397-418,共22页
The method of the phase plane is emploied to investigate the solitary and periodic traveling waves for a class of nonlinear dispersive partial differential equations.By using the bifurcation theory of dynamical system... The method of the phase plane is emploied to investigate the solitary and periodic traveling waves for a class of nonlinear dispersive partial differential equations.By using the bifurcation theory of dynamical systems to do qualitative analysis,all possible phase portraits in the parametric space for the traveling wave systems are obtained.It can be shown that the existence of a singular straight line in the traveling wave system is the reason why smooth solitary wave solutions converge to solitary cusp wave solution when parameters are varied.The different parameter conditions for the existence of solitary and periodic wave solutions of different kinds are rigorously determined. 展开更多
关键词 solitary wave Periodic wave Integrable system Bifurcation of phase portraits Smoothness of wave
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Solitary fibrous tumors in abdomen and pelvis:Imaging characteristics and radiologic-pathologic correlation 被引量:29
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作者 Xue-Ming Li Jing Reng +4 位作者 Peng Zhou Ying Cao Zhu-Zhong Cheng Yan Xiao Guo-Hui Xu 《World Journal of Gastroenterology》 SCIE CAS 2014年第17期5066-5073,共8页
AIM: To describe the imaging features of solitary fibrous tumors (SFTs) in the abdomen and pelvis, and the clinical and pathologic correlations.
关键词 Abdominal imaging solitary fibrous tumors Computed tomography Magnetic resonance imaging
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初步评估双源CT双能量技术在孤立性肺结节研究中的价值 被引量:29
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作者 王华斌 李苏建 +3 位作者 卢光明 张龙江 周长圣 王中秋 《放射学实践》 北大核心 2010年第5期504-508,共5页
目的:探讨双源CT双能量技术在孤立性肺结节(SPN)研究中的临床应用价值。方法:40例SPN患者经病理证实并行胸部CT常规平扫及双能量模式增强扫描,双能量增强扫描数据传入Siemens双源CT专用"Dual-Energy"工作站,选择"Liver V... 目的:探讨双源CT双能量技术在孤立性肺结节(SPN)研究中的临床应用价值。方法:40例SPN患者经病理证实并行胸部CT常规平扫及双能量模式增强扫描,双能量增强扫描数据传入Siemens双源CT专用"Dual-Energy"工作站,选择"Liver VNC"模式进行自动能量减影,得到虚拟平扫图像及碘分布图像。对SPN的虚拟平扫图像CT值和常规平扫图像SPN的CT值进行比较研究;对SPN内的碘分布图像CT值与SPN的强化值(增强图像SPN的CT值-平扫图像SPN的CT值)进行比较研究;对利用碘分布图像CT值和强化值在诊断SPN的符合率进行比较研究;研究虚拟平扫图像显示SPN内钙化灶以及纵隔淋巴结钙化灶的能力;将双能量扫描模式辐射剂量与单源扫描模式辐射剂量进行比较。结果:SPN的虚拟平扫图像CT值和常规平扫图像的CT值以及碘分布图像CT值与强化值显示出良好的一致性(相关系数分别为0.89,0.91)。以20HU作为阈值,利用SPN强化值评估其良恶性的准确度、敏感度、特异度分别为67.5%、71.4%、58.3%;利用SPN碘分布图像CT值评估其良恶性的准确度、敏感度、特异度分别为75.0%、74.2%、66.7%。虚拟平扫图像对SPN内钙化灶及纵隔淋巴结钙化的显示率为94.2%。双能量扫描模式平均辐射剂量(230.74±36.12)mGy.cm与单源扫描模式平均辐射剂量(238.14±29.12)mGy.cm,差异无统计学意义(t=0.12,P>0.05)。结论:双能量扫描技术能够一次扫描获得虚拟平扫图及碘剂分布图,不存在数据采集的位置和时间差,能够成功检出强化后SPN内的钙化灶,选择性重建SPN的虚拟平扫图像代替胸部常规平扫则可以明显减低患者的辐射剂量。 展开更多
关键词 体层摄影术 X线计算机 双能量成像 肺结节 孤立性
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CT三维重建联合快速现场评价辅助径向超声支气管镜对肺外周孤立性结节的诊断价值 被引量:25
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作者 王伟 展平 +7 位作者 谢青 胡慧娣 王羽超 袁琪 张倩 池传珍 徐春华 宋勇 《中华医学杂志》 CAS CSCD 北大核心 2019年第2期93-98,共6页
目的探讨CT三维重建(CT-3DR)联合快速现场评价(ROSE)辅助径向超声支气管镜(R-EBUS)对肺外周孤立性结节(SPN)的诊断价值。方法回顾性分析南京市胸科医院2016年3月至2017年3月收治的SPN共176例患者的临床资料,依据不同检查方式分为EG组[R-... 目的探讨CT三维重建(CT-3DR)联合快速现场评价(ROSE)辅助径向超声支气管镜(R-EBUS)对肺外周孤立性结节(SPN)的诊断价值。方法回顾性分析南京市胸科医院2016年3月至2017年3月收治的SPN共176例患者的临床资料,依据不同检查方式分为EG组[R-EBUS+引导鞘(GS)]、CTE组(CT-3DR+R-EBUS)、RE组(ROSE+R-EBUS)和三联组(CT-3DR+R-EBUS+ROSE),比较各组对SPN的诊断率、并发症、检查时间,探讨CT-3DR+ROSE+R-EBUS三联法对SPN的诊断效能及其影响因素,以及ROSE对SPN的诊断意义。结果EG组、CTE组、RE组、三联组的SPN总体诊断率分别为70.5%、70.0%、69.0%、74.0%,各组间差异均无统计学意义(均P>0.05);EG组、CTE组、RE组和三联组的检查时间分别是(34.0±6.3)、(26.6±6.8)、(27.2±7.8)和(19.4±5.4)min,CTE和RE组均显著短于EG组(均P<0.001),三联组均显著短于其他三组(均P<0.001)。CTE组和三联组术前接受CT-3DR导航,其定位结果与镜下病灶所在目标支气管实际位置符合率分别是87.5%和90.0%(P>0.05)。各组病例中,SPN长径≥2cm者诊断率均显著高于<2cm者(均P<0.05);R-EBUS超声探头位于病灶内部者诊断率均显著高于探头位于病灶一侧或偏离病灶者(均P<0.05);在EG组与RE组,SPN与胸膜之间距离≥2cm者诊断率均显著高于<2cm者(均P<0.05),但CTE组和三联组中未见类似现象;SPN病灶密度与诊断率无明显相关(均P>0.05)。RE组和三联组接受ROSE操作,ROSE读片结果与HE组织病理的诊断符合率为82.6%,Κappa值为0.608,ROSE的诊断灵敏度为0.818,特异度为0.846,阳性预测值为0.931,阴性预测值为0.647。结论CT-3DR术前导航和术中ROSE有助于提升R-EBUS对SPN的诊断效能,CT-3DR+R-EBUS+ROSE的三联法对外周型SPN具有较好的诊断价值且能显著缩短检查时间。 展开更多
关键词 肺结节 孤立性 图像处理 计算机辅助 快速现场评价 支气管腔内径向超声
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RANS-VOF Solver for Solitary Wave Run-up on A Circular Cylinder 被引量:20
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作者 曹洪建 万德成 《China Ocean Engineering》 SCIE EI CSCD 2015年第2期183-196,共14页
Simulation of solitary wave run-up on a vertical circular cylinder is carried out in a viscous numerical wave tank developed based on the open source codes Open FOAM. An incompressible two-phase flow solver naoe-FOAM-... Simulation of solitary wave run-up on a vertical circular cylinder is carried out in a viscous numerical wave tank developed based on the open source codes Open FOAM. An incompressible two-phase flow solver naoe-FOAM-SJTU is used to solve the Reynolds-Averaged Navier–Stokes(RANS) equations with the SST k ?? turbulence model. The PISO algorithm is utilized for the pressure-velocity coupling. The air-water interface is captured via Volume of Fluid(VOF) technique. The present numerical model is validated by simulating the solitary wave run-up and reflected against a vertical wall, and solitary wave run-up on a vertical circular cylinder. Comparisons between numerical results and available experimental data show satisfactory agreement. Furthermore, simulations are carried out to study the solitary wave run-up on the cylinder with different incident wave height H and different cylinder radius a. The relationships of the wave run-up height with the incident wave height H, cylinder radius a are analyzed. The evolutions of the scattering free surface and vortex shedding are also presented to give a better understanding of the process of nonlinear wave-cylinder interaction. 展开更多
关键词 RANS VOF solitary wave circular cylinder numerical wave tank naoe-FOAM-SJTU solver
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Experimental investigation of the generation of large-amplitude internal solitary wave and its interaction with a submerged slender body 被引量:22
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作者 WEI Gang DU Hui +4 位作者 XU XiaoHui ZHANG YuanMing QU ZiYun HU TianQun YOU YunXiang 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第2期301-310,共10页
A principle of generating the nonlinear large-amplitude internal wave in a stratified fluid tank with large cross-section is pro- posed according to the 'jalousie' control mode. A new wave-maker based on the princip... A principle of generating the nonlinear large-amplitude internal wave in a stratified fluid tank with large cross-section is pro- posed according to the 'jalousie' control mode. A new wave-maker based on the principle was manufactured and the experi- ments on the generation and evolution of internal solitary wave were conducted. Both the validity of the new device and ap- plicability range of the KdV-type internal soliton theory were tested. Furthermore, a measurement technique of hydrodynamic load of internal waves was developed. By means of accurately measuring slight variations of internal wave forces exerted on a slender body in the tank, their interaction characteristics were determined. It is shown that through establishing the similarity between the model scale in the stratified fluid tank and the full scale in the numerical simulation the obtained measurement re- suits of internal wave forces are confirmed to be correct. 展开更多
关键词 internal solitary wave wave-maker stratified fluid slender body INTERACTION
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A study of internal solitary waves observed on the continental shelf in the northwestern South China Sea 被引量:18
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作者 XU Zhenhua YIN Baoshu +2 位作者 HOU Yijun FAN Zhisong Antony K LIU 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2010年第3期18-25,共8页
Based on in-situ time series data from the acoustic Doppler current profiler (ADCP) and thermistor chain in Wenchang area, a sequence of internal solitary wave (ISW) packets was observed in September 2005, propaga... Based on in-situ time series data from the acoustic Doppler current profiler (ADCP) and thermistor chain in Wenchang area, a sequence of internal solitary wave (ISW) packets was observed in September 2005, propagating northwest on the continental shelf of the northwestern South China Sea (SCS). Corresponding to different stratification of the water column and tidal condition, both elevation and depression ISWs were observed at the same mooring location with amplitude of 35 m and 25 m respectively in different days. Regular arrival of the remarkable ISW packets at approximately the diurnal tidal period and the dominance of diurnal internal waves in the study area, strongly suggest that the main energy source of the waves is the diurnal tide. Notice that the wave packets were all riding on the troughs and shoulders of the internal tides, they were probably generated locally from the shelf break by the evolution of the internal tides due to nonlinear and dispersive effects. 展开更多
关键词 elevation internal solitary waves diurnal internal tide northwestern South China Sea
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Risk factors of poor prognosis and portal vein tumor thrombosis after curative resection of solitary hepatocellular carcinoma 被引量:17
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作者 Li Zhou Jing-An Rui +2 位作者 Shao-Bin Wang Shu-Guang Chen Qiang Qu 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2013年第1期68-73,共6页
BACKGROUND:Predictors of poor prognosis of solitary hepatocellular carcinoma(SHCC),a subgroup encompassing most patients with the malignancy,are still controversial.Hence,risk factors for portal vein tumor thrombosis(... BACKGROUND:Predictors of poor prognosis of solitary hepatocellular carcinoma(SHCC),a subgroup encompassing most patients with the malignancy,are still controversial.Hence,risk factors for portal vein tumor thrombosis(PVTT) in SHCC are obscure.The present study was designed to address this issue.METHOD:Clinicopathological and follow-up data for 156 consecutive patients with SHCC following curative hepatic resection were analyzed using uni-and multi-variate analyses.RESULTS:Univariate analysis showed that PVTT,tumornode-metastasis(TNM) stage,Edmondson-Steiner grade and preoperative serum alpha-fetoprotein(AFP) level were associated with the overall and disease-free survival,whereas tumor size only influenced the overall survival.In multivariate Cox regression tests,Edmondson-Steiner grade and TNM stage were independent prognostic markers for both overall and diseasefree survival.In addition,the Chi-square test showed that AFP level and Edmondson-Steiner grade were correlated with PVTT.Among them,only Edmondson-Steiner grade was shown to be of independent significance for PVTT in multi-variate logistic regression analysis.Additionally,AFP,the sole preoperative factor for PVTT,was not adequately sensitive and specific.CONCLUSIONS:Factors relating to post-surgical prognosis and PVTT in SHCC are all tumor-related.Of these,EdmondsonSteiner grade and TNM stage might be of particular importance in survival analysis.In addition,accurate prediction of PVTT by clinicopathological parameters before surgery remains difficult. 展开更多
关键词 solitary hepatocellular carcinoma curative resection PROGNOSIS portal vein tumor thrombosis
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Neural network-based computer-aided diagnosis in distinguishing malignant from benign solitary pulmonary nodules by computed tomography 被引量:13
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作者 CHEN Hui WANG Xiao-hua +1 位作者 MA Da-qing MA Bin-rong 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第14期1211-1215,共5页
Background Computer-aided diagnosis (CAD) of lung cancer is the subject of many current researches. Statistical methods and artificial neural networks have been applied to more quantitatively characterize solitary p... Background Computer-aided diagnosis (CAD) of lung cancer is the subject of many current researches. Statistical methods and artificial neural networks have been applied to more quantitatively characterize solitary pulmonary nodules (SPNs). In this study, we developed a CAD scheme based on an artificial neural network to distinguish malignant from benign SPNs on thin-section computed tomography (CT) images, and investigated how the CAD scheme can help radiologists with different levels of experience make diagnostic decisions. Methods Two hundred thin-section CT images of SPNs with proven diagnoses (135 small peripheral lung cancers and 65 benign nodules) were analyzed. Three clinical features and nine CT signs of each case were studied by radiologists, and the indices of qualitative diagnosis were quantified. One hundred and forty nodules were selected randomly to form training samples, on which the neural network model was built. The remaining 60 nodules, forming test samples, were presented to 9 radiologists with 3-20 years of clinical experience, accompanied by standard reference images. The radiologists were asked to determine whether a nodule was malignant or benign first without and then with CAD output. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis. Results CAD outputs on test samples had higher agreement with pathological diagnoses (Kappa=0.841, P〈0.001). Compared with diagnostic results without CAD output, the average area under the ROC curve with CAD output was 0.96 (P〈0.001) for junior radiologists, 0.94 (P=0.014) for secondary radiologists and 0.96 (P=0.221) for senior radiologists, respectively. The differences in diagnostic performance with CAD output among the three levels of radiologists were not statistically significant (P=0.584, 0.920 and 0.707, respectively). Conclusions This CAD scheme based on an artificial neural network could improve diagnostic performance and assist radiologists in distinguishing maligna 展开更多
关键词 diagnosis computer-assisted neural networks (computer) solitary pulmonary nodules computed tomography ROC curve
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A study of SAR remote sensing of internal solitary waves in the north of the South China Sea:Ⅰ.Simulation of internal tide transformation 被引量:12
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作者 FAN Zhisong ZHANG Yuanling SONG Mei 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2008年第4期39-56,共18页
For settlement of the well-known problem of contemporary radar imaging models, i. e. , the problem of a general underestimation of radar signatures of hydrodynamic features over oceanic internal waves and underwater b... For settlement of the well-known problem of contemporary radar imaging models, i. e. , the problem of a general underestimation of radar signatures of hydrodynamic features over oceanic internal waves and underwater bottom topography in tidal waters at high radar frequency bands ( X-band and C-band), the impact of the ocean surface mixed layer turbulence and the significance of strat- ified oceanic model on SAR remote sensing of internal solitary waves are proposed. In the north of the South China Sea by utilizing some observed data of background field the nonlinearity coefficient, the dispersion coefficient, the horizontal variability coefficient and the phase speed in the generalized K-dV equation are determined approximately. Through simulations of internal tide transfor- mation the temporal evolution and spatial distribution of the vertical displacement and horizontal velocity of internal wave field are obtained. The simulation results indicate that the maximum amplitudes of internal solitary waves occur at depth 35 m, but the maximum current speeds take place at depth 20 m in this area of the sea (about 20°30'N, 114°E) in August. It was noticed that considering the effects of flood current and ebb current respectively is appropriate to investigate influence of the background shear flow on coefficients of the K-dV equation. The obtained results provide the possibility for the simulation of SAR signatures of internal solitary waves under considering the impact of ocean surface mixed layer turbulence in the companion paper. 展开更多
关键词 internal tide internal solitary waves TURBULENCE SAR remote sensing
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Mooring observations of internal solitary waves in the deep basin west of Luzon Strait 被引量:14
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作者 HUANG Xiaodong ZHAO Wei +1 位作者 TIAN Jiwei YANG Qingxuan 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2014年第3期82-89,共8页
A total of 137 internal solitary waves (ISWs) are captured during a field experiment conducted in the deep basin west of the Luzon Strait (LS) from March to August, 2010. Mooring observations reveal that a fully d... A total of 137 internal solitary waves (ISWs) are captured during a field experiment conducted in the deep basin west of the Luzon Strait (LS) from March to August, 2010. Mooring observations reveal that a fully developed ISW owns a maximum westward velocity of more than 1.8 m/s and an amplitude of about 200 m. The ISWs in the South China Sea (SCS) are most active in July, which may be due to the strong stratification in summer. Most of the ISW episodes are detected around and after the 1st or 15th lunar day, indicating that the ISW in the SCS is triggered by astronomic tides. Half part of the observed ISWs were detected around 19:00 local time, which can be explained by the fact that type-a ISWs emerged in the evening at roughly the same time each day. The propagation direction of the ISWs and the astronomic tides in the LS show that the area south of the Batan Island is probably the main source region of the type-a ISWs, while the area south of Itbayat Island and south of the Batan Island is likely the main source region of the type-b ISWs observed at the mooring. Moreover, for the resonance of semidiurnal internal tides emitting from the double ridges in the LS, the underwater ridge south of the Itbayat Island and south of the Batan Island is believed to favor the generation of the energetic ISWs. 展开更多
关键词 internal solitary wave South China Sea OBSERVATION nonlinear internal wave
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New exact solitary wave solutions to generalized mKdV equation and generalized Zakharov-Kuzentsov equation 被引量:14
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作者 套格图桑 斯仁道尔吉 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第6期1143-1148,共6页
In this paper, based on hyperbolic tanh-function method and homogeneous balance method, and auxiliary equation method, some new exact solitary solutions to the generalized mKdV equation and generalized Zakharov-Kuzent... In this paper, based on hyperbolic tanh-function method and homogeneous balance method, and auxiliary equation method, some new exact solitary solutions to the generalized mKdV equation and generalized Zakharov-Kuzentsov equation are constructed by the method of auxiliary equation with function transformation with aid of symbolic computation system Mathematica. The method is of important significance in seeking new exact solutions to the evolution equation with arbitrary nonlinear term. 展开更多
关键词 generalized mKdV equation generalized Zakharov-Kuzentsov equation nonlinear evolution equation auxiliary equation exact solitary wave solutions
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A novel (G'/G)-expansion method and its application to the Boussinesq equation 被引量:14
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作者 Md.Nur Alam Md.Ali Akbar Syed Tauseef Mohyud-Din 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第2期34-43,共10页
In this article, a novel (G'/G)-expansion method is proposed to search for the traveling wave solutions of nonlinear evolution equations. We construct abundant traveling wave solutions involving parameters to the B... In this article, a novel (G'/G)-expansion method is proposed to search for the traveling wave solutions of nonlinear evolution equations. We construct abundant traveling wave solutions involving parameters to the Boussinesq equation by means of the suggested method. The performance of the method is reliable and useful, and gives more general exact solutions than the existing methods. The new (G'/G)-expansion method provides not only more general forms of solutions but also cuspon, peakon, soliton, and periodic waves. 展开更多
关键词 (G'/G)-expansion method Boussinesq equation solitary wave solutions auxiliary nonlinear ordinary differential equation
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A New Approach to Solve Nonlinear Wave Equations 被引量:15
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作者 FUZun-Tao LIUShi-Kuo 《Communications in Theoretical Physics》 SCIE CAS CSCD 2003年第1期27-30,共4页
From the nonlinear sine-Gordon equation, new transformations are obtained in this paper, which are applied to propose a new approach to construct exact periodic solutions to nonlinear wave equations. It is shown that ... From the nonlinear sine-Gordon equation, new transformations are obtained in this paper, which are applied to propose a new approach to construct exact periodic solutions to nonlinear wave equations. It is shown that more new periodic solutions can be obtained by this new approach, and more shock wave solutions or solitary wave solutions can be got under their limit conditions. 展开更多
关键词 sine-Gordon equation Jacobi elliptic function nonlinear wave equation periodic wave solution solitary wave solution
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Clinical features of solitary necrotic nodule of the liver 被引量:13
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作者 Zhou, Yan-Ming Li, Bin +4 位作者 Xu, Feng Wang, Bin Li, Dian-Qi Liu, Peng Yang, Jia-Mei 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2008年第5期485-489,共5页
BACKGROUND: Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease. METHOD: The medical records of 51 patients with histologically ... BACKGROUND: Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease. METHOD: The medical records of 51 patients with histologically confirmed solitary necrotic nodule of the liver who received surgical resection at our institution were retrospectively reviewed. RESULTS: Solitary necrotic nodule of the liver was found mainly in males (68.6%, 35/51), and patients ranged in age from 5 to 69 years with a mean of 45.3. Most of the patients (72.5%) had no significant symptoms, with negative results for the serum tumor markers alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen. The mean diameter of the nodule was 23 mm (range 10-55 mm). Compared with ultrasonographic and computed tomography findings, the specific features of magnetic resonance imaging were more helpful for differential diagnosis of the disease. CONCLUSIONS: Solitary necrotic nodule of the liver is a rare nonmalignant lesion, showing no notable symptoms and potential complications. The pathological change of the disease is not significant over a lifetime. Conservative treatment and clinical follow-up are recommended. 展开更多
关键词 liver neoplasm solitary necrotic nodule
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孤立性纤维瘤临床及影像诊断探讨(附3例报告并文献复习) 被引量:15
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作者 曾效力 樊长姝 +4 位作者 秦红卫 陈艺莉 何秀珍 谭光明 高承亚 《实用医学影像杂志》 2006年第1期13-15,共3页
目的探讨孤立性纤维瘤的临床及影像学特点,提高对该疾病的诊断水平。方法回顾性分析3例经穿刺活检与手术病理证实的孤立性纤维瘤临床及影像学资料,并作文献复习。结果孤立性纤维瘤在临床上可无临床症状或因肿瘤压迫出现不典型症状,发生... 目的探讨孤立性纤维瘤的临床及影像学特点,提高对该疾病的诊断水平。方法回顾性分析3例经穿刺活检与手术病理证实的孤立性纤维瘤临床及影像学资料,并作文献复习。结果孤立性纤维瘤在临床上可无临床症状或因肿瘤压迫出现不典型症状,发生于胸膜的巨大孤立性纤维瘤可以合并低血糖症。在超声上表现为不均匀中等或中低回声;在X线平片上表现为均匀致密的孤立性肿块;在CT上1例表现为巨大囊实性肿块,增强后实性部分中度强化,另1例为均匀致密的软组织肿块;在MRI上肿瘤实性部分表现为在T1WI上呈中、低混杂信号,T2WI上呈低信号,肿瘤内可见明显囊变区。结论孤立性纤维瘤是一种少见疾病,必须结合既往病史、临床症状、各种影像学资料综合分析,才有可能作出准确的诊断。 展开更多
关键词 孤立性纤维性肿瘤 超声 X线平片 体层摄影术 X线计算机 磁共振成像
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广义KDV方程的显示行波解 被引量:14
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作者 孙峪怀 《四川师范大学学报(自然科学版)》 CAS CSCD 2001年第4期339-341,共3页
非线性演化方程 ,特别是广义KDV方程因其丰富的数学物理内含而备受人们关注 ,其精确解的研究在理论和应用上都有重要的意义 .求出了广义KDV方程的显示精确解 ,同时给出了解成立的条件 。
关键词 非线性演化方程 行波解 精确解 孤立波 广义KDV方程 非线性偏微分方程
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The (G'/G, 1/G)-expansion method and its application to travelling wave solutions of the Zakharov equations 被引量:13
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作者 LI Ling-xiao LI Er-qiang WANG Ming-liang 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2010年第4期454-462,共9页
The (G'/G, 1/G)-expansion method for finding exact travelling wave solutions of nonlinear evolution equations, which can be thought of as an extension of the (G'/G)-expansion method proposed recently, is present... The (G'/G, 1/G)-expansion method for finding exact travelling wave solutions of nonlinear evolution equations, which can be thought of as an extension of the (G'/G)-expansion method proposed recently, is presented. By using this method abundant travelling wave so- lutions with arbitrary parameters of the Zakharov equations are successfully obtained. When the parameters are replaced by special values, the well-known solitary wave solutions of the equations are rediscovered from the travelling waves. 展开更多
关键词 The (G /G 1/G)-expansion method travelling wave solutions homogeneous balance solitary wave solutions Zakharov equations.
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