A simple and rapid liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for simultaneous quantification of pioglitazone and candesartan in human plasma.Irbesart...A simple and rapid liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for simultaneous quantification of pioglitazone and candesartan in human plasma.Irbesartan was used as an internal standard.The analytes were extracted from human plasma samples by solid-phase extraction technique using a Strata-X 33 mm polymeric sorbent.The reconstituted samples were chromatographed on a C18 column by using a 80:20(v/v) mixture of acetonitrile and 0.1% formic acid as the mobile phase at a flow rate of 0.8 mL/min.The calibration curves obtained were linear(rZ0.99) over the concentration range of 15-3000 ng/mL for pioglitazone and 5-608 ng/mL for candesartan.The results of the intra-and inter-day precision and accuracy studies were well within the acceptable limits.A run time of 2.7 min for each sample made it possible to analyze more than 300 plasma samples per day.The proposed method was found to be applicable to clinical studies.展开更多
A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma....A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma. Carbamazepine was used as an internal standard. Analytes and the internal standard were extracted from human plasma by solid-phase extraction technique using Waters Oasis HLB 1 cm3 （30 mg） extraction cartridge. The reconstituted samples were chromatographed on a Hypurity advance C18 column （50mm × 4.6mm, 5 gm） using a mixture of acetonitrile -5 mM ammonium acetate buffer （pH-4.0） （50：50, v/v） as the mobile phase at a flow rate of 0.8mL/min. The calibration curve obtained was linear （r_〉0.99） over the concentration range of 2.01-400.06 ng/mL for telmisartan and 0.05 -10.01 ng/mL for amlodipine. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies.展开更多
Generation of self-generated annular magnetic fields at the rear side of a solid target driven by relativistic laser pulse is investigated by using theoretical analysis and particle-in-cell simulations.The spatial str...Generation of self-generated annular magnetic fields at the rear side of a solid target driven by relativistic laser pulse is investigated by using theoretical analysis and particle-in-cell simulations.The spatial strength distribution of magnetic fields can be accurately predicted by calculating the net flow caused by the superposition of source flow and return flow of hot electrons.The theoretical model established shows good agreement with the simulation results,indicating that the magnetic-field strength scales positively to the temperature of hot electrons.This provides us a way to improve the magnetic-field generation by using a micro-structured plasma grating in front of the solid target.Compared with that for a common flat target,hot electrons can be effectively heated with the well-designed grating size,leading to a stronger magnetic field.The spatial distribution of magnetic fields can be modulated by optimizing the grating period and height as well as the incident angle of the laser pulse.展开更多
In this study,a single-doped phosphors yttrium aluminum garnet(Y_(3)Al_(5)O_(12),YAG):Ce^(3+),single-doped YAG:Sc^(3+),and double-doped phosphors YAG:Ce^(3+),Sc^(3+) were prepared by spark plasma sintering(SPS)(lower ...In this study,a single-doped phosphors yttrium aluminum garnet(Y_(3)Al_(5)O_(12),YAG):Ce^(3+),single-doped YAG:Sc^(3+),and double-doped phosphors YAG:Ce^(3+),Sc^(3+) were prepared by spark plasma sintering(SPS)(lower than 1 200℃).The characteristics of synthesized phosphors were determined using scanning electron microscopy(SEM),X-ray diffraction(XRD),and fluorescence spectroscopy.During SPS,the lattice structure of YAG was maintained by the added Ce^(3+) and Sc^(3+).The emission wavelength of YAG:Ce^(3+) prepared from SPS(425-700 nm) was wider compared to that of YAG:Ce^(3+) prepared from high-temperature solid-state reaction(HSSR)(500-700 nm).The incorporation of low-dose Sc^(3+) in YAG:Ce^(3+) moved the emission peak towards the short wavelength.展开更多
A plasma is produced in air by using a high-intensity Q-switch Nd：YAG pulsed laser to irradiate a solid target, and the impulses delivering from the plasma to the target are measured at different laser power densitie...A plasma is produced in air by using a high-intensity Q-switch Nd：YAG pulsed laser to irradiate a solid target, and the impulses delivering from the plasma to the target are measured at different laser power densities. Analysing the formation process of laser plasma and the laser supported detonation wave （LSDW） and using fluid mechanics theory and Pirri＇s methods, an approximately theoretical solution of the impulse delivering from the plasma to the target under our experimental condition is found. Furthermore, according to the formation time of plasma and the variation of pressure in plasma in a non-equilibrium state, a physical model of the interaction between the pulse laser and the solid target is developed. The plasma evolutions with time during and after the laser pulse irradiating the target are simulated numerically by using a three-dimensional difference scheme. And the numerical solutions of the impulse delivering from the plasma to the target are obtained. A comparison among the theoretical, numerical and experimental results and their analyses are performed. The experimental results are explained reasonably. The consistency between numerical results and experimental results implies that the numerical calculation model used in this paper can well describe the mechanical action of the laser on the target.展开更多
SUS430 （16% - 17% （mass fraction） Cr） can be used as interconnects for solid oxide fuel cells （SOFCs） that operate at lower temperatures （ 〈 800 ℃ ）. However, oxidation of steel can occur readily at elevated...SUS430 （16% - 17% （mass fraction） Cr） can be used as interconnects for solid oxide fuel cells （SOFCs） that operate at lower temperatures （ 〈 800 ℃ ）. However, oxidation of steel can occur readily at elevated temperatures leading to the formation of Cr2O3 and spinel （Fe3O4） and thus greatly degrades the performance of the fuel cell. The aim of this work was to reduce oxide growth, in particular, the Cr2O3 phase, through the application of La0.8Sr0.2MnO3-δ （LSM2O） and La0.8Sr0.2FeO3-δ（LSF20） coatings by atmospheric plasma spraying technology （APS）. Oxide growth was characterized by using X-ray diffraction （XRD）, scanning electron microscopy （SEM） with an energy dispersive X-ray （EDX） analyzer. During oxidation of fifty 20 h cycles at 800 ℃ in air, the samples with coatings remained very stable, whereas significant spallation and weight loss were observed for the uncoated steel. LSF20 presents apparently advantages in reducing oxidation growth, interface resistance and inhibition of diffusion of chromium. After exposure in air at 800 ℃ for 1000 h, the interfacial resistance of LSF20-coated alloy is lowered by more than 23 times to that of LSM20-coated layer.展开更多
设计了一种结合正方形和八边形环的波束扫描超材料平面反射阵列天线。相比于传统的阵列天线设计,运用了新的相位补偿方法,即通过组合反射阵列单元在介质基板的材料不同时得到的相位曲线实现0~360°的相位补偿,使得阵列单元的相位曲...设计了一种结合正方形和八边形环的波束扫描超材料平面反射阵列天线。相比于传统的阵列天线设计,运用了新的相位补偿方法,即通过组合反射阵列单元在介质基板的材料不同时得到的相位曲线实现0~360°的相位补偿,使得阵列单元的相位曲线不需要完全覆盖0~360°,并且采用埃尔米特插值的方式解决相位特性曲线线性度差的问题。该方法的优势是具有广泛适应性,降低了对阵列单元的设计要求。利用这种方法设计了几款单层平面反射阵列天线,仿真结果显示反射波束方向与预期设定值相符合,且副瓣与主瓣都相差至少15 d B。通过调节超材料固态等离子体激励区域的范围即改变阵列单元的谐振结构,实现了空间波束扫描,为平面反射阵列天线的设计提供了一种新思路。展开更多
Daily meat consumption produces a lot of bone waste, and dumped bone waste without treatment would result in environmental hazards. Conventional treatment methods of waste bones have some disadvantages. Herein, an inv...Daily meat consumption produces a lot of bone waste, and dumped bone waste without treatment would result in environmental hazards. Conventional treatment methods of waste bones have some disadvantages. Herein, an investigation of bone waste treated using thermal plasma technology is presented. A high-temperature plasma torch operated at 25.2 kW was used to treat bone waste for seven minutes. The bone waste was finally changed into vitric matter and lost 2/3 of its weight after the treatment. The process was highly efficient, economical, convenient, and fuel-free. This method could be used as an alternative for disposal of bone waste, small infectious animals, hazardous hospital waste, etc.展开更多
文摘A simple and rapid liquid chromatography-tandem mass spectrometric(LC-MS/MS) assay method has been developed and fully validated for simultaneous quantification of pioglitazone and candesartan in human plasma.Irbesartan was used as an internal standard.The analytes were extracted from human plasma samples by solid-phase extraction technique using a Strata-X 33 mm polymeric sorbent.The reconstituted samples were chromatographed on a C18 column by using a 80:20(v/v) mixture of acetonitrile and 0.1% formic acid as the mobile phase at a flow rate of 0.8 mL/min.The calibration curves obtained were linear(rZ0.99) over the concentration range of 15-3000 ng/mL for pioglitazone and 5-608 ng/mL for candesartan.The results of the intra-and inter-day precision and accuracy studies were well within the acceptable limits.A run time of 2.7 min for each sample made it possible to analyze more than 300 plasma samples per day.The proposed method was found to be applicable to clinical studies.
文摘A rapid and sensitive liquid chromatography-tandem mass spectrometric （LC-MS/MS） assay method has been developed and fully validated for the simultaneous quantification of telmisartan and amlodipine in human plasma. Carbamazepine was used as an internal standard. Analytes and the internal standard were extracted from human plasma by solid-phase extraction technique using Waters Oasis HLB 1 cm3 （30 mg） extraction cartridge. The reconstituted samples were chromatographed on a Hypurity advance C18 column （50mm × 4.6mm, 5 gm） using a mixture of acetonitrile -5 mM ammonium acetate buffer （pH-4.0） （50：50, v/v） as the mobile phase at a flow rate of 0.8mL/min. The calibration curve obtained was linear （r_〉0.99） over the concentration range of 2.01-400.06 ng/mL for telmisartan and 0.05 -10.01 ng/mL for amlodipine. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. A run time of 2.5 min for each sample made it possible to analyze more than 400 human plasma samples per day. The proposed method was found to be applicable to clinical studies.
基金supported by the National Natural Science Foundation of China(Grant Nos.12175310,12305268,and U2241281)the Natural Science Foundation of Hunan Province(Grant Nos.2024JJ6184,2022JJ20042,and 2021JJ40653)the Scientific Research Foundation of Hunan Provincial Education Department(Grant Nos.22B0655 and 22A0435)。
文摘Generation of self-generated annular magnetic fields at the rear side of a solid target driven by relativistic laser pulse is investigated by using theoretical analysis and particle-in-cell simulations.The spatial strength distribution of magnetic fields can be accurately predicted by calculating the net flow caused by the superposition of source flow and return flow of hot electrons.The theoretical model established shows good agreement with the simulation results,indicating that the magnetic-field strength scales positively to the temperature of hot electrons.This provides us a way to improve the magnetic-field generation by using a micro-structured plasma grating in front of the solid target.Compared with that for a common flat target,hot electrons can be effectively heated with the well-designed grating size,leading to a stronger magnetic field.The spatial distribution of magnetic fields can be modulated by optimizing the grating period and height as well as the incident angle of the laser pulse.
基金Funded by the Primary Research and Development Plan of Jiangsu Province(No.BE2016175)。
文摘In this study,a single-doped phosphors yttrium aluminum garnet(Y_(3)Al_(5)O_(12),YAG):Ce^(3+),single-doped YAG:Sc^(3+),and double-doped phosphors YAG:Ce^(3+),Sc^(3+) were prepared by spark plasma sintering(SPS)(lower than 1 200℃).The characteristics of synthesized phosphors were determined using scanning electron microscopy(SEM),X-ray diffraction(XRD),and fluorescence spectroscopy.During SPS,the lattice structure of YAG was maintained by the added Ce^(3+) and Sc^(3+).The emission wavelength of YAG:Ce^(3+) prepared from SPS(425-700 nm) was wider compared to that of YAG:Ce^(3+) prepared from high-temperature solid-state reaction(HSSR)(500-700 nm).The incorporation of low-dose Sc^(3+) in YAG:Ce^(3+) moved the emission peak towards the short wavelength.
基金Project supported by the National Natural Science Foundation of China (Grant No 60578015)the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No 20050288025)the Foundation of the Ministry of Education of China for Outstanding Young Teachers in University (2003-2008)
文摘A plasma is produced in air by using a high-intensity Q-switch Nd：YAG pulsed laser to irradiate a solid target, and the impulses delivering from the plasma to the target are measured at different laser power densities. Analysing the formation process of laser plasma and the laser supported detonation wave （LSDW） and using fluid mechanics theory and Pirri＇s methods, an approximately theoretical solution of the impulse delivering from the plasma to the target under our experimental condition is found. Furthermore, according to the formation time of plasma and the variation of pressure in plasma in a non-equilibrium state, a physical model of the interaction between the pulse laser and the solid target is developed. The plasma evolutions with time during and after the laser pulse irradiating the target are simulated numerically by using a three-dimensional difference scheme. And the numerical solutions of the impulse delivering from the plasma to the target are obtained. A comparison among the theoretical, numerical and experimental results and their analyses are performed. The experimental results are explained reasonably. The consistency between numerical results and experimental results implies that the numerical calculation model used in this paper can well describe the mechanical action of the laser on the target.
文摘SUS430 （16% - 17% （mass fraction） Cr） can be used as interconnects for solid oxide fuel cells （SOFCs） that operate at lower temperatures （ 〈 800 ℃ ）. However, oxidation of steel can occur readily at elevated temperatures leading to the formation of Cr2O3 and spinel （Fe3O4） and thus greatly degrades the performance of the fuel cell. The aim of this work was to reduce oxide growth, in particular, the Cr2O3 phase, through the application of La0.8Sr0.2MnO3-δ （LSM2O） and La0.8Sr0.2FeO3-δ（LSF20） coatings by atmospheric plasma spraying technology （APS）. Oxide growth was characterized by using X-ray diffraction （XRD）, scanning electron microscopy （SEM） with an energy dispersive X-ray （EDX） analyzer. During oxidation of fifty 20 h cycles at 800 ℃ in air, the samples with coatings remained very stable, whereas significant spallation and weight loss were observed for the uncoated steel. LSF20 presents apparently advantages in reducing oxidation growth, interface resistance and inhibition of diffusion of chromium. After exposure in air at 800 ℃ for 1000 h, the interfacial resistance of LSF20-coated alloy is lowered by more than 23 times to that of LSM20-coated layer.
文摘设计了一种结合正方形和八边形环的波束扫描超材料平面反射阵列天线。相比于传统的阵列天线设计,运用了新的相位补偿方法,即通过组合反射阵列单元在介质基板的材料不同时得到的相位曲线实现0~360°的相位补偿,使得阵列单元的相位曲线不需要完全覆盖0~360°,并且采用埃尔米特插值的方式解决相位特性曲线线性度差的问题。该方法的优势是具有广泛适应性,降低了对阵列单元的设计要求。利用这种方法设计了几款单层平面反射阵列天线,仿真结果显示反射波束方向与预期设定值相符合,且副瓣与主瓣都相差至少15 d B。通过调节超材料固态等离子体激励区域的范围即改变阵列单元的谐振结构,实现了空间波束扫描,为平面反射阵列天线的设计提供了一种新思路。
基金supported by the Regional Research Center for Environmental Technology of Thermal Plasma (ETTP) at Inha University designated by Ministry of Commerce,Industry and Energy (MOCIE) of South Korea (2006)
文摘Daily meat consumption produces a lot of bone waste, and dumped bone waste without treatment would result in environmental hazards. Conventional treatment methods of waste bones have some disadvantages. Herein, an investigation of bone waste treated using thermal plasma technology is presented. A high-temperature plasma torch operated at 25.2 kW was used to treat bone waste for seven minutes. The bone waste was finally changed into vitric matter and lost 2/3 of its weight after the treatment. The process was highly efficient, economical, convenient, and fuel-free. This method could be used as an alternative for disposal of bone waste, small infectious animals, hazardous hospital waste, etc.
