Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of...Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.展开更多
为提高酪蛋白的提取效果,通过探究预先脱脂牛奶和未预先脱脂牛奶在不同p H(4.5、4.6、4.7、4.8、4.9)条件下沉淀酪蛋白的效果,得出了先离心脱脂,然后在p H 4.6的条件下进行酪蛋白凝集,最后在离心管中悬浮沉淀洗涤,可以达到最佳的提取效...为提高酪蛋白的提取效果,通过探究预先脱脂牛奶和未预先脱脂牛奶在不同p H(4.5、4.6、4.7、4.8、4.9)条件下沉淀酪蛋白的效果,得出了先离心脱脂,然后在p H 4.6的条件下进行酪蛋白凝集,最后在离心管中悬浮沉淀洗涤,可以达到最佳的提取效果,得率和纯度分别是98.58%和97.52%.实验结果表明,该法操作简单,可有效提高酪蛋白的提取效果和纯度,缩短提取时间,实验教学效果良好.展开更多
The biofilm formation on equipment surfaces in dairy manufacturing is a major concern for industry and consumers alike, which may affect the safety and quality of dairy products. In order to identify the bio-contamina...The biofilm formation on equipment surfaces in dairy manufacturing is a major concern for industry and consumers alike, which may affect the safety and quality of dairy products. In order to identify the bio-contamination risk of materials commonly used in dairy manufacturing,</span><span style="font-family:""> </span><span style="font-family:Verdana;">adhesion of </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">Staphylococcus aureus</span></i><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;"> on glass coated by two kinds of UHT milk (whole milk and skimmed milk) was investigated. It is known that adhesion is mainly governed by surface physicochemical properties, for that,</span><span style="font-family:""> </span><span style="font-family:Verdana;">the effect of milk components on physicochemical properties of glass and bacterial surfaces were exanimated through contact angle measurements. MATLAB software was used to evaluate the ability of </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">S.</span></i><i><span style="font-family:""> </span></i><i><span style="font-family:Verdana;">aureus</span></i><i><span style="font-family:Verdana;"></i></span></i><i><span style="font-family:""> </span></i><span style="font-family:Verdana;">adhesion on glass.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The hydrophobic quantitative and electron acceptor characteristics of the glass appear to increase with the presence of fat in milk, while its electron donor property</span><span style="font-family:""> </span><span style="font-family:Verdana;">decreases with this component. The percentage of occupied surface of untreated glass was more important than in treated surfaces for 50% of the strains studied.</span><span style="font-family:""> </span><span style="font-family:Verdana;">As well, the percentage of occupied surface by bacterial strains in untreated glass by skimmed milk is g展开更多
[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the...[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the two decolorization technologies. [Method] Periplaneta americana L. skimmed cream was decolored with activated carbon and macroporous resin, and freeze-dried to collect solid decolorization products. By investigating the yield, decolorization rate, protein retention rate and decolorization operation process, the advantages and disadvantages of the two decolorization technologies were compared. [Result] Both activated carbon and macroporous resin can be used for decolorization. To be specific, macroporous resin-decolorization is superior in the yield and protein retention rate, while activated carbon-decolorization is superior in decolorization rate and decolorization operation process. [Conclusion] Macroporous resin-decolorization can be used if protein is the main ingredient required in the experiment, while activated carbon-decolorization can be used if protein is not the main ingredient required.展开更多
文摘Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin.
文摘为提高酪蛋白的提取效果,通过探究预先脱脂牛奶和未预先脱脂牛奶在不同p H(4.5、4.6、4.7、4.8、4.9)条件下沉淀酪蛋白的效果,得出了先离心脱脂,然后在p H 4.6的条件下进行酪蛋白凝集,最后在离心管中悬浮沉淀洗涤,可以达到最佳的提取效果,得率和纯度分别是98.58%和97.52%.实验结果表明,该法操作简单,可有效提高酪蛋白的提取效果和纯度,缩短提取时间,实验教学效果良好.
文摘The biofilm formation on equipment surfaces in dairy manufacturing is a major concern for industry and consumers alike, which may affect the safety and quality of dairy products. In order to identify the bio-contamination risk of materials commonly used in dairy manufacturing,</span><span style="font-family:""> </span><span style="font-family:Verdana;">adhesion of </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">Staphylococcus aureus</span></i><i><span style="font-family:Verdana;"></i></span></i><span style="font-family:Verdana;"> on glass coated by two kinds of UHT milk (whole milk and skimmed milk) was investigated. It is known that adhesion is mainly governed by surface physicochemical properties, for that,</span><span style="font-family:""> </span><span style="font-family:Verdana;">the effect of milk components on physicochemical properties of glass and bacterial surfaces were exanimated through contact angle measurements. MATLAB software was used to evaluate the ability of </span><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">S.</span></i><i><span style="font-family:""> </span></i><i><span style="font-family:Verdana;">aureus</span></i><i><span style="font-family:Verdana;"></i></span></i><i><span style="font-family:""> </span></i><span style="font-family:Verdana;">adhesion on glass.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The hydrophobic quantitative and electron acceptor characteristics of the glass appear to increase with the presence of fat in milk, while its electron donor property</span><span style="font-family:""> </span><span style="font-family:Verdana;">decreases with this component. The percentage of occupied surface of untreated glass was more important than in treated surfaces for 50% of the strains studied.</span><span style="font-family:""> </span><span style="font-family:Verdana;">As well, the percentage of occupied surface by bacterial strains in untreated glass by skimmed milk is g
基金Supported by National Natural Science Foundation of China(30560181)~~
文摘[Objective] The aim of this study was to investigate the decolorization ef- fects of activated carbon and macroporous resin on Periplaneta americana L. skimmed cream and compare the advantages and disadvantages of the two decolorization technologies. [Method] Periplaneta americana L. skimmed cream was decolored with activated carbon and macroporous resin, and freeze-dried to collect solid decolorization products. By investigating the yield, decolorization rate, protein retention rate and decolorization operation process, the advantages and disadvantages of the two decolorization technologies were compared. [Result] Both activated carbon and macroporous resin can be used for decolorization. To be specific, macroporous resin-decolorization is superior in the yield and protein retention rate, while activated carbon-decolorization is superior in decolorization rate and decolorization operation process. [Conclusion] Macroporous resin-decolorization can be used if protein is the main ingredient required in the experiment, while activated carbon-decolorization can be used if protein is not the main ingredient required.
