目的探讨全麻下儿童泪小管断裂吻合联合环形硅胶管置入的手术方法并观察术后疗效。方法我院2011年1月至2014年12月住院手术的外伤性泪小管断裂患儿22例（22只眼）,年龄14个月~12岁,受伤后2 d内手术16例,3 d 4例,7 d1例,最长在受伤后2周...目的探讨全麻下儿童泪小管断裂吻合联合环形硅胶管置入的手术方法并观察术后疗效。方法我院2011年1月至2014年12月住院手术的外伤性泪小管断裂患儿22例（22只眼）,年龄14个月~12岁,受伤后2 d内手术16例,3 d 4例,7 d1例,最长在受伤后2周。全麻后显微镜下寻找泪小管鼻、颞侧断端,带橄榄头的双探针硅胶管分别从上下泪小点插入,经泪小管断端,穿过鼻泪管并从鼻腔钩出打结成环形。用8-0可吸收缝线缝合断端泪小管壁连同周围组织2~3针。术后随访6个月。结果显微镜下顺利完成手术。术中2例泪小点撕裂,用9-0尼龙线缝合,术后愈合。1例术后3天硅胶管脱落,一直溢泪。3个月后拔除泪道环形硅胶管并冲洗泪道,1例在拔管后1个月泪道冲洗不通,患儿溢泪。除上述2例泪道阻塞外,其余20例泪道通畅,眼睑皮肤愈合好。结论儿童泪小管断裂在全麻下顺利完成泪小管端端对位吻合,经上下泪小点置管有一定难度,可确保较高成功率,术后患儿几无刺激症状,疗效好,是较理想的手术方法。展开更多
Aim： To assess the effect of estradiol-17β （E2） and bisphenol A （BPA） administered chronically by implanting a silicone tube throughout pregnancy and lactation on male pups＇ reproductive system in ICR mice. Met...Aim： To assess the effect of estradiol-17β （E2） and bisphenol A （BPA） administered chronically by implanting a silicone tube throughout pregnancy and lactation on male pups＇ reproductive system in ICR mice. Methods： Female mice were implanted with a tube filled with 10 ng, 500 ng, 1 μg, or 10 μg of E2, or 100 μg or 5 mg of BPA, before mating. The tube was kept in the mice throughout pregnancy and lactation, until the pups had weaned at 4 weeks of age. During the period, E2 was released from the tube at 120 pg or 6, 12 or 120 ng/day, and BPA at 1.2 or 60 μg/day. Results： Most of the mice given 1 μg and 10 lag of E2 did not maintain their pregnancy. However, the other groups showed high rates of birth, more than 70%. At age of 4 weeks, the male pups were killed. Body weight and reproductive organ weights （testes, epididymides and accessory reproductive glands） in the treated groups did not differ from the control values, whereas the percentage of seminiferous tubules in the testis with mature spermatids was significantly lower in the groups given 10 ng and 500 ng of E2 and 5 mg of BPA than that in the control. Conclusion： Chronic exposure to E2 and BPA might disrupt spermatogenesis in male pups. （Asian JAndrol 2008 Mar; 10： 271-276）展开更多
文摘目的探讨全麻下儿童泪小管断裂吻合联合环形硅胶管置入的手术方法并观察术后疗效。方法我院2011年1月至2014年12月住院手术的外伤性泪小管断裂患儿22例（22只眼）,年龄14个月~12岁,受伤后2 d内手术16例,3 d 4例,7 d1例,最长在受伤后2周。全麻后显微镜下寻找泪小管鼻、颞侧断端,带橄榄头的双探针硅胶管分别从上下泪小点插入,经泪小管断端,穿过鼻泪管并从鼻腔钩出打结成环形。用8-0可吸收缝线缝合断端泪小管壁连同周围组织2~3针。术后随访6个月。结果显微镜下顺利完成手术。术中2例泪小点撕裂,用9-0尼龙线缝合,术后愈合。1例术后3天硅胶管脱落,一直溢泪。3个月后拔除泪道环形硅胶管并冲洗泪道,1例在拔管后1个月泪道冲洗不通,患儿溢泪。除上述2例泪道阻塞外,其余20例泪道通畅,眼睑皮肤愈合好。结论儿童泪小管断裂在全麻下顺利完成泪小管端端对位吻合,经上下泪小点置管有一定难度,可确保较高成功率,术后患儿几无刺激症状,疗效好,是较理想的手术方法。
文摘Aim： To assess the effect of estradiol-17β （E2） and bisphenol A （BPA） administered chronically by implanting a silicone tube throughout pregnancy and lactation on male pups＇ reproductive system in ICR mice. Methods： Female mice were implanted with a tube filled with 10 ng, 500 ng, 1 μg, or 10 μg of E2, or 100 μg or 5 mg of BPA, before mating. The tube was kept in the mice throughout pregnancy and lactation, until the pups had weaned at 4 weeks of age. During the period, E2 was released from the tube at 120 pg or 6, 12 or 120 ng/day, and BPA at 1.2 or 60 μg/day. Results： Most of the mice given 1 μg and 10 lag of E2 did not maintain their pregnancy. However, the other groups showed high rates of birth, more than 70%. At age of 4 weeks, the male pups were killed. Body weight and reproductive organ weights （testes, epididymides and accessory reproductive glands） in the treated groups did not differ from the control values, whereas the percentage of seminiferous tubules in the testis with mature spermatids was significantly lower in the groups given 10 ng and 500 ng of E2 and 5 mg of BPA than that in the control. Conclusion： Chronic exposure to E2 and BPA might disrupt spermatogenesis in male pups. （Asian JAndrol 2008 Mar; 10： 271-276）
