Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which incre...Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment.展开更多
The large-sized rammed-earth building foundations on the Panlongcheng site at Huangpi are remains of early Shang period palace complex. The No. 1 Panlongcheng palace consists of four rooms with wooden-framed walls. Th...The large-sized rammed-earth building foundations on the Panlongcheng site at Huangpi are remains of early Shang period palace complex. The No. 1 Panlongcheng palace consists of four rooms with wooden-framed walls. The two rooms in the middle each have two doors on the northern and southern sides respectively；while the two end rooms have only southern doors. So the No. 1 palace must have been in the center of the whole building complex. The roof supported by peripheral columns and wooden-framed walls can be reconstructed to be hipped and single- or double- eaved. The hypothesis that the No. 1 palace may have had projecting-eaves columns has not been confirmed. The No. 2 palace is an open hall without peripheral walls and room division； its roof is supported by peripheral columns only. The idea of reconstructing it as a building with pilasters and multiple rooms seems to lack archaeological evidence. The remaining vestiges show that there were side corridors in the two flanks of the main hall of the No. 2 palace. Referring to the Shang period palace material unearthed from the Shang city-site at Yanshi and other localities, it can be inferred that either of the Nos. 1 and 2 palaces must have had an eastern corridor and a western one, and, in addition, the No. 2 palace must have had a southern corridor with a gate house. The Nos. 1--3 palaces of the Panlongcheng site formed three compounds located one behind another, and belonged to the type of court-and-living building complex. Among them the No. 2 palace was the outer court for holding great ceremonies, the No. 1 palace was the inner court for handling daily administrative affairs, and the No. 3 palace was the king and queen's living place. To the southeast of the No. 2 palace remains a group of rammed-earth house-foundations, which must have been left over from another type of palace building, possibly an ancestral temple. The remaining city-walls at Panlongcheng must have belonged to the peripheral city-walls. The palace area is in the northeast of the encl展开更多
LiCoO2 gradient coated LiNi0.96Co0.04O2 material and iso-structure LiNi0.8Co0.2O2 material (the same molar ratio 8/2 of Ni/Co in the two materials) as cathode for lithium-ion batteries were synthesized with a co-preci...LiCoO2 gradient coated LiNi0.96Co0.04O2 material and iso-structure LiNi0.8Co0.2O2 material (the same molar ratio 8/2 of Ni/Co in the two materials) as cathode for lithium-ion batteries were synthesized with a co-precipitation method. Microstructure of iso-structure LiNi0.8Co0.2O2 were about the same as that of LiNiO2, and the structure of the coated material was much more similar to that of LiCoO2 based on the X-ray diffraction patterns. The cycling voltammetry and galvanostatic cycle tests show that the properties of the coated material were improved significantly. The first specific charge and discharge capacity for the coated material was 249.20 mAh·g-1 and 207.90 mAh·g-1 respectively, and the specific discharge capacity for the 100th cycle was still 186.02 mAh·g-1 with an irreversible loss of only 21.1 mAh·g-1. This showed that the new material had a good lithium intercalation-deintrercalation performance. Meanwhile, the mechanism of the sintering reaction was proposed. During the sintering reaction of the precursor with LiOH, the Li+-ion permeated into the body of precursors because the shape of the precursor particles was not changed basically based on scanning electronic microscopy. So, the layer microstructure of the precursor is important for the layer microstructure of lithium nickel cobalt oxides electrode material.展开更多
Because of the development of tourist activities and the facilities in the show cave, the closed system of show cave has been changed into the complicated open system. The great number of the visitors and the landscap...Because of the development of tourist activities and the facilities in the show cave, the closed system of show cave has been changed into the complicated open system. The great number of the visitors and the landscape lights give great deal of thermoenergy to the show cave system, especially the high intensive lights make the temperature nearby goes up very fast and reduce the humidity. After the visitors leaving and the lights switching off, the temperature goes down and humidity increases even upto saturation, the condensation taken place. In the dry seasons, the cave humidity is relative low, even down to 40 50 percent. The administrations of show cave rushes the water to clean the touristic trails and keep the high humidity as to protect the cave environment. Under the function of artificial readjustment, the humidity of Yaolin cave atmosphere reaches to 97-100 percent throughtout the year.展开更多
基金supported by grants from National Natural Science Foundation of China (Grant Nos.81371990,81625015,81601945,and 81530070)the Program for Changjiang Scholars and Innovative Research Team in University (IRT_16R37)
文摘Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment.
文摘The large-sized rammed-earth building foundations on the Panlongcheng site at Huangpi are remains of early Shang period palace complex. The No. 1 Panlongcheng palace consists of four rooms with wooden-framed walls. The two rooms in the middle each have two doors on the northern and southern sides respectively；while the two end rooms have only southern doors. So the No. 1 palace must have been in the center of the whole building complex. The roof supported by peripheral columns and wooden-framed walls can be reconstructed to be hipped and single- or double- eaved. The hypothesis that the No. 1 palace may have had projecting-eaves columns has not been confirmed. The No. 2 palace is an open hall without peripheral walls and room division； its roof is supported by peripheral columns only. The idea of reconstructing it as a building with pilasters and multiple rooms seems to lack archaeological evidence. The remaining vestiges show that there were side corridors in the two flanks of the main hall of the No. 2 palace. Referring to the Shang period palace material unearthed from the Shang city-site at Yanshi and other localities, it can be inferred that either of the Nos. 1 and 2 palaces must have had an eastern corridor and a western one, and, in addition, the No. 2 palace must have had a southern corridor with a gate house. The Nos. 1--3 palaces of the Panlongcheng site formed three compounds located one behind another, and belonged to the type of court-and-living building complex. Among them the No. 2 palace was the outer court for holding great ceremonies, the No. 1 palace was the inner court for handling daily administrative affairs, and the No. 3 palace was the king and queen's living place. To the southeast of the No. 2 palace remains a group of rammed-earth house-foundations, which must have been left over from another type of palace building, possibly an ancestral temple. The remaining city-walls at Panlongcheng must have belonged to the peripheral city-walls. The palace area is in the northeast of the encl
文摘LiCoO2 gradient coated LiNi0.96Co0.04O2 material and iso-structure LiNi0.8Co0.2O2 material (the same molar ratio 8/2 of Ni/Co in the two materials) as cathode for lithium-ion batteries were synthesized with a co-precipitation method. Microstructure of iso-structure LiNi0.8Co0.2O2 were about the same as that of LiNiO2, and the structure of the coated material was much more similar to that of LiCoO2 based on the X-ray diffraction patterns. The cycling voltammetry and galvanostatic cycle tests show that the properties of the coated material were improved significantly. The first specific charge and discharge capacity for the coated material was 249.20 mAh·g-1 and 207.90 mAh·g-1 respectively, and the specific discharge capacity for the 100th cycle was still 186.02 mAh·g-1 with an irreversible loss of only 21.1 mAh·g-1. This showed that the new material had a good lithium intercalation-deintrercalation performance. Meanwhile, the mechanism of the sintering reaction was proposed. During the sintering reaction of the precursor with LiOH, the Li+-ion permeated into the body of precursors because the shape of the precursor particles was not changed basically based on scanning electronic microscopy. So, the layer microstructure of the precursor is important for the layer microstructure of lithium nickel cobalt oxides electrode material.
文摘Because of the development of tourist activities and the facilities in the show cave, the closed system of show cave has been changed into the complicated open system. The great number of the visitors and the landscape lights give great deal of thermoenergy to the show cave system, especially the high intensive lights make the temperature nearby goes up very fast and reduce the humidity. After the visitors leaving and the lights switching off, the temperature goes down and humidity increases even upto saturation, the condensation taken place. In the dry seasons, the cave humidity is relative low, even down to 40 50 percent. The administrations of show cave rushes the water to clean the touristic trails and keep the high humidity as to protect the cave environment. Under the function of artificial readjustment, the humidity of Yaolin cave atmosphere reaches to 97-100 percent throughtout the year.
