AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed...AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500mL.L(-1), i.g.) was used to induce gastric mucosa damage. RESULTS: RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L(-1) ethanol challenge, the ulcer area found in the rats with 7d sleep deprivation (19.15 +/- 4.2)mm(2) was significantly lower (P【0.01) than the corresponding control (53.7 +/- 8.1) mm(2). CONCLUSION: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.展开更多
This article is devoted to experimental study on the control of the oblique shock wave around the ramp in a low-temperature supersonic flow by means of the magnetohydrodynamic （MHD） flow control technique. The purpo...This article is devoted to experimental study on the control of the oblique shock wave around the ramp in a low-temperature supersonic flow by means of the magnetohydrodynamic （MHD） flow control technique. The purpose of the experiments is to take advantage of MHD interaction to weaken the oblique shock wave strength by changing the boundary flow characteristics around the ramp. Plasma columns are generated by pulsed direct current （ DC ） discharge, the magnetic fields are generated by Nd-Fe-B rare-earth permanent magnets and the oblique shock waves in supersonic flow are generated by the ramp. The Lorentz body force effect of MHD interaction on the plasma-induced airflow velocity is verified through particle image velocimetry（PIV）measurements. The experimental results from the supersonic wind tunnel indicate that the MHD flow control can drastically change the flow characteristics of the airflow around the ramp and decrease the ratio of the Pitot pressure after shock wave to that before it by up to 19.66% ,which leads to the decline in oblique shock wave strength. The oblique shock waves in front of the ramp move upstream by the action of the Lorentz body force. The discharge characteristics are analyzed and the MHD interaction time and consumed energy are determined with the help of the pulsed DC discharge images. The interaction parameter corresponding to the boundary layer velocity can reach 1.3 from the momentum conservation equation. The velocity of the plasma column in the magnetic field is much faster than that in the absence of magnetic field force. The plasma can strike the neutral gas molecules to transfer momentum and accelerate the flow around the ramp.展开更多
A three-electrode high-energy plasma synthetic jet(PSJ) actuator was used for shock wave control. This actuator is an enhanced version of the two-electrode actuator as a high-voltage trigger electrode is added to incr...A three-electrode high-energy plasma synthetic jet(PSJ) actuator was used for shock wave control. This actuator is an enhanced version of the two-electrode actuator as a high-voltage trigger electrode is added to increase the cavity volume and the input energy while retaining a relatively low disruptive voltage. The electrical properties were studied using current-voltage measurements, and the energy consumption was calculated. To assess the jet strength, the penetration of PSJ was compared with empirical values, and the results show that the momentum flux ratio of PSJ for a capacitance of 0.96, 1.6, and 3 μF was approximately equal to 0.6, 1.0, and 1.3, respectively. The interaction of PSJ with shock waves was acquired using high-speed shadowgraph imaging. The shock was generated by a 25° compression ramp in Mach 2 flow, and PSJ actuator was placed up-stream of the compression ramp. Under the action of PSJ, the strength of the shock was notably weakened, and the near-wall part of the shock was entirely eliminated. The results show the good control effect of the three-electrode high-energy PSJ in high-speed flow.展开更多
文摘AIM: To investigate if sleep deprivation is able to increase the expression of inducible heat shock protein 70 in gastric mucosa and its possible role in mucosal defense. METHODS: Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol (500mL.L(-1), i.g.) was used to induce gastric mucosa damage. RESULTS: RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L(-1) ethanol challenge, the ulcer area found in the rats with 7d sleep deprivation (19.15 +/- 4.2)mm(2) was significantly lower (P【0.01) than the corresponding control (53.7 +/- 8.1) mm(2). CONCLUSION: Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.
基金National Natural Science Foundation of China(50776100)
文摘This article is devoted to experimental study on the control of the oblique shock wave around the ramp in a low-temperature supersonic flow by means of the magnetohydrodynamic （MHD） flow control technique. The purpose of the experiments is to take advantage of MHD interaction to weaken the oblique shock wave strength by changing the boundary flow characteristics around the ramp. Plasma columns are generated by pulsed direct current （ DC ） discharge, the magnetic fields are generated by Nd-Fe-B rare-earth permanent magnets and the oblique shock waves in supersonic flow are generated by the ramp. The Lorentz body force effect of MHD interaction on the plasma-induced airflow velocity is verified through particle image velocimetry（PIV）measurements. The experimental results from the supersonic wind tunnel indicate that the MHD flow control can drastically change the flow characteristics of the airflow around the ramp and decrease the ratio of the Pitot pressure after shock wave to that before it by up to 19.66% ,which leads to the decline in oblique shock wave strength. The oblique shock waves in front of the ramp move upstream by the action of the Lorentz body force. The discharge characteristics are analyzed and the MHD interaction time and consumed energy are determined with the help of the pulsed DC discharge images. The interaction parameter corresponding to the boundary layer velocity can reach 1.3 from the momentum conservation equation. The velocity of the plasma column in the magnetic field is much faster than that in the absence of magnetic field force. The plasma can strike the neutral gas molecules to transfer momentum and accelerate the flow around the ramp.
基金supported by the National Natural Science Foundation of China(Grant Nos.11372349&11502295)the Nature Science Fund for Distinguished Young Scholars of National University of Defense Technology(Grant No.CJ110101)
文摘A three-electrode high-energy plasma synthetic jet(PSJ) actuator was used for shock wave control. This actuator is an enhanced version of the two-electrode actuator as a high-voltage trigger electrode is added to increase the cavity volume and the input energy while retaining a relatively low disruptive voltage. The electrical properties were studied using current-voltage measurements, and the energy consumption was calculated. To assess the jet strength, the penetration of PSJ was compared with empirical values, and the results show that the momentum flux ratio of PSJ for a capacitance of 0.96, 1.6, and 3 μF was approximately equal to 0.6, 1.0, and 1.3, respectively. The interaction of PSJ with shock waves was acquired using high-speed shadowgraph imaging. The shock was generated by a 25° compression ramp in Mach 2 flow, and PSJ actuator was placed up-stream of the compression ramp. Under the action of PSJ, the strength of the shock was notably weakened, and the near-wall part of the shock was entirely eliminated. The results show the good control effect of the three-electrode high-energy PSJ in high-speed flow.
