目的:观察加减复方积雪草汤治疗慢性肾小球肾炎慢性肾脏病(CKD) 3期患者的临床疗效。方法:将86例慢性肾小球肾炎CKD3期患者随机分成2组,对照组予常规治疗,治疗组在对照组治疗方案的基础上加用加减复方积雪草汤治疗,疗程均为3个月,观察2...目的:观察加减复方积雪草汤治疗慢性肾小球肾炎慢性肾脏病(CKD) 3期患者的临床疗效。方法:将86例慢性肾小球肾炎CKD3期患者随机分成2组,对照组予常规治疗,治疗组在对照组治疗方案的基础上加用加减复方积雪草汤治疗,疗程均为3个月,观察2组治疗后症状、证候积分、血肌酐(SCr)、尿蛋白/肌酐比值(Upr/Cr)、24 h尿蛋白定量(24 h Upr)、尿素氮(BUN)、肾小球滤过率(eGFR)、安全性等指标变化。结果:临床疗效总有效率治疗组88.37%,对照组为67.44%,差异均有统计学意义(P<0.05),治疗组优于对照组。治疗后,与本组治疗前及对照组治疗后比较,治疗组中医证候积分明显下降,差异均有统计学意义(P<0.01);治疗组SCr、BUN、24 h Upr、Upr/Cr各值分别与治疗前比较,且与对照组同期比较,均显著降低,差异均有统计学意义(P<0.05);治疗组eGFR较治疗前明显升高(P<0.05);对照组eGFR与治疗前比较,差异无统计学意义(P>0.05)。治疗组治疗后e GFR明显高于对照组,差异有统计学意义(P<0.05)。与药物相关的不良反应,治疗组3例,对照组2例,2组比较,差异无统计学意义(P>0.05)。且治疗过程中不良反应程度较轻,对症处理后指标好转,可继续参与研究。结论:加减复方积雪草汤可减少慢性肾小球肾炎CKD3期患者24 h尿蛋白量,改善肾功能,延缓肾病进展,对慢性肾小球肾炎CKD3期有确切疗效,且安全性好。展开更多
A grouped feeding trial, nitrogen balance trial and metabolism trial for Taihe silky fowls were conducted to study the effects of dietary methionine levels on performance, nitrogen retention and serum urea nitrogen co...A grouped feeding trial, nitrogen balance trial and metabolism trial for Taihe silky fowls were conducted to study the effects of dietary methionine levels on performance, nitrogen retention and serum urea nitrogen concentration, and to determine the total and digestible methionine requirements of Taihe silky fowls in early stage. The results showed that: (1)Dietary Met levels had no significant effect on weight gain(WG)(P>0.05), but feed intake(FI), feed conversion rate(FCR) and serum urea nirogen concentration were significantly improved as dietary Met level increased. (2)With the increase of dietary Met levels, nitrogen retention rate of Taihe silky fowls significantly increased, but excess methionine reduced the nitrogen retention. (3)There were significant differences in methionine requirements between male and female Taihe silky fowls,and the methionine requirements of male were higher than that of female Taihe silky fowls at 4～12 weeks of age. The results suggested that during 0～4 weeks the total and digestible methionine requirements of Taihe silky fowls fed on a diet (19.24% crude protein, metabolizable energy 12.26 MJ/kg and 0.26% supplemental methionine) was 0.44% and 0.41% of dietary levels, respectively. During 4～9 weeks, based on a diet(17.37% crude protein, metabolizable energy 12.26 MJ/kg and 0.23% supplemental methionine) the total and digestible methionine requirements of male Taihe silky fowls was 0.35% and 0.33% of dietary levels, respectively, the female’s was 0.31% and 0.30%, respectively.During 9～12 weeks, fed on a diet(17.00% crude protein, metabolizable energy 12.27 MJ/kg and (0.22%) supplemental methionine) the total and digestible methionine requirements of male Taihe silky fowls was 0.26% and 0.25% of dietary levels,respectively, the female’s was 0.24% and 0.23%, respectively.展开更多
目的研究藏药黑果枸杞水煎液对运动疲劳小鼠的影响。方法按体重将小鼠随机分为5组:低、中、高3个剂量实验组(黑果枸杞:3,6,12 mg·g^(-1)),对照组(红牛0.02 m L·g^(-1))和空白组(蒸馏水0.02 m L·g^(-1)),每组40只,连续灌...目的研究藏药黑果枸杞水煎液对运动疲劳小鼠的影响。方法按体重将小鼠随机分为5组:低、中、高3个剂量实验组(黑果枸杞:3,6,12 mg·g^(-1)),对照组(红牛0.02 m L·g^(-1))和空白组(蒸馏水0.02 m L·g^(-1)),每组40只,连续灌胃给药30 d。末次给药1 h后,采取负重(体重的4%)在(25±2)℃水中游泳40 min,造成疲劳,通过力竭游泳建立小鼠疲劳模型。通过试剂盒法测定肌糖原和肝糖原;以全自动生化仪测定泳前、泳后即刻和泳后恢复30 min后小鼠血糖、血清尿素氮、乳酸等生化指标。结果与空白组的力竭游泳时间为(2.98±0.56)h相比,中、高2个剂量实验组分别为(3.94±0.61),(4.37±0.72)h,实验组可显著延长小鼠力竭游泳时间,差异有统计学意义(P<0.05)。与空白组的血糖、血清尿素氮、乳酸含量分别为(6.33±1.35),(8.92±0.14),(10.27±1.45)mmol·L^(-1)相比,高剂量实验组泳后恢复30 min,还可明显增加小鼠血糖含量(8.15±1.28)mmol·L^(-1),降低血清尿素氮水平(7.04±1.34)mmol·L^(-1),减少乳酸(7.05±0.47)mmol·L^(-1)的产生,差异有统计学意义(P<0.05)。结论藏药黑果枸杞对小鼠运动疲劳有一定的缓解作用。展开更多
文摘目的:观察加减复方积雪草汤治疗慢性肾小球肾炎慢性肾脏病(CKD) 3期患者的临床疗效。方法:将86例慢性肾小球肾炎CKD3期患者随机分成2组,对照组予常规治疗,治疗组在对照组治疗方案的基础上加用加减复方积雪草汤治疗,疗程均为3个月,观察2组治疗后症状、证候积分、血肌酐(SCr)、尿蛋白/肌酐比值(Upr/Cr)、24 h尿蛋白定量(24 h Upr)、尿素氮(BUN)、肾小球滤过率(eGFR)、安全性等指标变化。结果:临床疗效总有效率治疗组88.37%,对照组为67.44%,差异均有统计学意义(P<0.05),治疗组优于对照组。治疗后,与本组治疗前及对照组治疗后比较,治疗组中医证候积分明显下降,差异均有统计学意义(P<0.01);治疗组SCr、BUN、24 h Upr、Upr/Cr各值分别与治疗前比较,且与对照组同期比较,均显著降低,差异均有统计学意义(P<0.05);治疗组eGFR较治疗前明显升高(P<0.05);对照组eGFR与治疗前比较,差异无统计学意义(P>0.05)。治疗组治疗后e GFR明显高于对照组,差异有统计学意义(P<0.05)。与药物相关的不良反应,治疗组3例,对照组2例,2组比较,差异无统计学意义(P>0.05)。且治疗过程中不良反应程度较轻,对症处理后指标好转,可继续参与研究。结论:加减复方积雪草汤可减少慢性肾小球肾炎CKD3期患者24 h尿蛋白量,改善肾功能,延缓肾病进展,对慢性肾小球肾炎CKD3期有确切疗效,且安全性好。
文摘A grouped feeding trial, nitrogen balance trial and metabolism trial for Taihe silky fowls were conducted to study the effects of dietary methionine levels on performance, nitrogen retention and serum urea nitrogen concentration, and to determine the total and digestible methionine requirements of Taihe silky fowls in early stage. The results showed that: (1)Dietary Met levels had no significant effect on weight gain(WG)(P>0.05), but feed intake(FI), feed conversion rate(FCR) and serum urea nirogen concentration were significantly improved as dietary Met level increased. (2)With the increase of dietary Met levels, nitrogen retention rate of Taihe silky fowls significantly increased, but excess methionine reduced the nitrogen retention. (3)There were significant differences in methionine requirements between male and female Taihe silky fowls,and the methionine requirements of male were higher than that of female Taihe silky fowls at 4～12 weeks of age. The results suggested that during 0～4 weeks the total and digestible methionine requirements of Taihe silky fowls fed on a diet (19.24% crude protein, metabolizable energy 12.26 MJ/kg and 0.26% supplemental methionine) was 0.44% and 0.41% of dietary levels, respectively. During 4～9 weeks, based on a diet(17.37% crude protein, metabolizable energy 12.26 MJ/kg and 0.23% supplemental methionine) the total and digestible methionine requirements of male Taihe silky fowls was 0.35% and 0.33% of dietary levels, respectively, the female’s was 0.31% and 0.30%, respectively.During 9～12 weeks, fed on a diet(17.00% crude protein, metabolizable energy 12.27 MJ/kg and (0.22%) supplemental methionine) the total and digestible methionine requirements of male Taihe silky fowls was 0.26% and 0.25% of dietary levels,respectively, the female’s was 0.24% and 0.23%, respectively.
