Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The ...Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly（glutamic acid） segments as shell. The biocompatibility of the micelles was studied. The release of the anticancer drug doxorubicin from the micelles was investigated in vitro. The results showed that the sustaining release of the drug could last for 60 h. The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells, 75% cancer cells were killed under appropriate in vitro incubation.展开更多
A novel mixed-valent heterometallic pentanuclear CoⅢ3 CoⅡ Dy Ⅲ cluster has been rationally assembled taking advantage of a bifunctional ligand with o-vanillin and tripodal tris(hydroxymethyl)aminomethane units. Thi...A novel mixed-valent heterometallic pentanuclear CoⅢ3 CoⅡ Dy Ⅲ cluster has been rationally assembled taking advantage of a bifunctional ligand with o-vanillin and tripodal tris(hydroxymethyl)aminomethane units. This unique heterometallic cluster represents a rare example of T-shaped molecules exhibiting slow magnetic relaxation.展开更多
Anisotropic nanopatterns have potentials in constructing novel plasmonic structures which have various applications in such as super-resolution microscopy, medicine, and sensors. However, it remains challenging to bui...Anisotropic nanopatterns have potentials in constructing novel plasmonic structures which have various applications in such as super-resolution microscopy, medicine, and sensors. However, it remains challenging to build big anisotropic nanopatterns that are suitable for big noble metal nanoparticles. Herein, we report a simple and reliable strategy for constructing DNA origami-based big anisotropic nanopatterns with controlled size and shape, nanoscale resolution, and fully addressability. Two kinds of basic DNA origami nanoblocks-cross-shaped and rectangular DNA origami units were used. We have demonstrated that by encoding nanoblocks' edges, anisotropic higher-order nanopatterns, such as dimer, trimer, tetramer and mini "windmill" like pentamer nanopatterns could be constructed. To show the potential use as template to direct the assembly of anisotropic nanoparticles arrays, a proof of concept work was conducted by anchoring streptavidin nanoparticles on the "windmill" template to form a chiral array. Significantly, these nanopatterns have the sizes of hundreds of nanometers, which are in principle also suitable for big noble metal nanoparticles arrays.展开更多
基金supported by the National Basic Research Program of China (973 Program,2011CB606206)National High-Tech Research & Development Program of China (863 Program,2007AA021801)+2 种基金National Natural Science Foundation of China (50633020 & 50830105)Sichuan Youth Science & Technology Foundation (07ZQ026-013)Open Fund of Engineering Research Center of Biomass Materials,Ministry of Education (2010LF4002)
文摘Amphiphilic dendritic poly（glutarnic acid）-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly（glutamic acid） as the macroinitiator in the ring-opening polymerization of NCA-Phe. The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly（glutamic acid） segments as shell. The biocompatibility of the micelles was studied. The release of the anticancer drug doxorubicin from the micelles was investigated in vitro. The results showed that the sustaining release of the drug could last for 60 h. The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells, 75% cancer cells were killed under appropriate in vitro incubation.
基金supported by the National Natural Science Foundation of China (91022009, 20921002)
文摘A novel mixed-valent heterometallic pentanuclear CoⅢ3 CoⅡ Dy Ⅲ cluster has been rationally assembled taking advantage of a bifunctional ligand with o-vanillin and tripodal tris(hydroxymethyl)aminomethane units. This unique heterometallic cluster represents a rare example of T-shaped molecules exhibiting slow magnetic relaxation.
基金supported by the National Basic Research Program of China (2012CB932600)the National Natural Science Foundation of China(20725516, 90913014, 21028005 and 21103219)Shanghai Pujiang Program (11PJ1412000)
文摘Anisotropic nanopatterns have potentials in constructing novel plasmonic structures which have various applications in such as super-resolution microscopy, medicine, and sensors. However, it remains challenging to build big anisotropic nanopatterns that are suitable for big noble metal nanoparticles. Herein, we report a simple and reliable strategy for constructing DNA origami-based big anisotropic nanopatterns with controlled size and shape, nanoscale resolution, and fully addressability. Two kinds of basic DNA origami nanoblocks-cross-shaped and rectangular DNA origami units were used. We have demonstrated that by encoding nanoblocks' edges, anisotropic higher-order nanopatterns, such as dimer, trimer, tetramer and mini "windmill" like pentamer nanopatterns could be constructed. To show the potential use as template to direct the assembly of anisotropic nanoparticles arrays, a proof of concept work was conducted by anchoring streptavidin nanoparticles on the "windmill" template to form a chiral array. Significantly, these nanopatterns have the sizes of hundreds of nanometers, which are in principle also suitable for big noble metal nanoparticles arrays.
基金National Natural Science Foundation(No.20676038)Key Project of Science and Technology for Ministry of Education(107045)the Special Projects for key laboratories in Shanghai(05DZ22302,06DZ22008)
