Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play ...Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play an important role in the growth arrest induced in transformed cells. Although the stability of the p21( WAF1) mRNA could be altered by different signals, cell differentiation and numerous influencing factors. However, recent studies suggest that two known mechanisms of epigenesis, i.e.gene inactivation by methylation in promoter region and changes to an inactive chromatin by histone deacetylation, seem to be the best candidate mechanisms for inactivation of p21( WAF1). To date, almost no coding region p21(WAF1) mutations have been found in tumor cells, despite extensive screening of hundreds of various tumors. Hypermethylation of the p21(WAF1) promoter region may represent an alternative mechanism by which the p21(WAF1/CIP1) gene can be inactivated. The reduction of cellular DNMT protein levels also induces a corresponding rapid increase in the cell cycle regulator p21(WAF1) protein demonstrating a regulatory link between DNMT and p21(WAF1) which is independent of methylation of DNA. Both histone hyperacetylation and hypoacetylation appear to be important in the carcinoma process, and induction of the p21(WAF1) gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis. Here, we review the influence of histone acetylation and DNA methylation on p21(WAF1) transcription, and affection of pathways or factors associated such as p 53, E2A, Sp1 as well as several histone deacetylation inhibitors.展开更多
Depositional sequences may be distinguished into six ranks of units as giga-, mega-, meso-, ortho-, sub- and micro-sequence, and are interpreted to be formed during the eustatic cycles with time-intervals of 500-6000 ...Depositional sequences may be distinguished into six ranks of units as giga-, mega-, meso-, ortho-, sub- and micro-sequence, and are interpreted to be formed during the eustatic cycles with time-intervals of 500-6000 Ma, 60-120 Ma, 30-40 Ma, 2-5 Ma, 0.1-0.4 Ma and 0.02-0.04 Ma respectively. All of them are thought to be essentially related to cosmological cycles, except the megasequence which may be caused by the long-term geothermal cycles on cratons. We deem that the depositional sequences, though often influenced variably by local tectonics and other factors, are primarily global and periodic in nature. We also hold that as one of the planets within the Galaxy, the earth must have been affected in various ways by other asteroids, and that the depositional sequences are merely the responses of the hydrosphere to the cosmological cycles in sedimentation.展开更多
文摘Cell cycle progression is regulated by interactions between cyclins and cyclin-dependent kinases (CDKs). p21(WAF1) is one of the CIP/KIP family which inhibits CDKs activity. Increased expression of p21(WAF1) may play an important role in the growth arrest induced in transformed cells. Although the stability of the p21( WAF1) mRNA could be altered by different signals, cell differentiation and numerous influencing factors. However, recent studies suggest that two known mechanisms of epigenesis, i.e.gene inactivation by methylation in promoter region and changes to an inactive chromatin by histone deacetylation, seem to be the best candidate mechanisms for inactivation of p21( WAF1). To date, almost no coding region p21(WAF1) mutations have been found in tumor cells, despite extensive screening of hundreds of various tumors. Hypermethylation of the p21(WAF1) promoter region may represent an alternative mechanism by which the p21(WAF1/CIP1) gene can be inactivated. The reduction of cellular DNMT protein levels also induces a corresponding rapid increase in the cell cycle regulator p21(WAF1) protein demonstrating a regulatory link between DNMT and p21(WAF1) which is independent of methylation of DNA. Both histone hyperacetylation and hypoacetylation appear to be important in the carcinoma process, and induction of the p21(WAF1) gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis. Here, we review the influence of histone acetylation and DNA methylation on p21(WAF1) transcription, and affection of pathways or factors associated such as p 53, E2A, Sp1 as well as several histone deacetylation inhibitors.
基金This paper is an outcome of the research programof sequence stratigraphy (SSLC) supported by the Stateac~sinn of ScienCe and
文摘Depositional sequences may be distinguished into six ranks of units as giga-, mega-, meso-, ortho-, sub- and micro-sequence, and are interpreted to be formed during the eustatic cycles with time-intervals of 500-6000 Ma, 60-120 Ma, 30-40 Ma, 2-5 Ma, 0.1-0.4 Ma and 0.02-0.04 Ma respectively. All of them are thought to be essentially related to cosmological cycles, except the megasequence which may be caused by the long-term geothermal cycles on cratons. We deem that the depositional sequences, though often influenced variably by local tectonics and other factors, are primarily global and periodic in nature. We also hold that as one of the planets within the Galaxy, the earth must have been affected in various ways by other asteroids, and that the depositional sequences are merely the responses of the hydrosphere to the cosmological cycles in sedimentation.
