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基于体积力法的船体自航性能数值预报 被引量:20
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作者 吴召华 陈作钢 代燚 《上海交通大学学报》 EI CAS CSCD 北大核心 2013年第6期943-949,共7页
为实现船舶自航性能的快速预报,应用计算流体力学(CFD)方法,采用一种便捷的描述型体积力模型替代螺旋桨的作用,分别在无舵实船自航点和有舵模型自航点2种条件下对MOERI(Korea Research Institute for Ships and Ocean Engineering)集装... 为实现船舶自航性能的快速预报,应用计算流体力学(CFD)方法,采用一种便捷的描述型体积力模型替代螺旋桨的作用,分别在无舵实船自航点和有舵模型自航点2种条件下对MOERI(Korea Research Institute for Ships and Ocean Engineering)集装箱船(KCS)的黏性自由面流场进行了数值模拟.依据等推力法、敞水计算和螺旋桨敞水曲线等,计算船体自航性能相关参数.计算结果与试验结果吻合良好.研究结果表明,使用描述型体积力法可以便捷而较为准确地预报船体自航性能. 展开更多
关键词 船体自航性能 描述型体积力模型 实船自航点 船模自航点
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Effect of flexibility on unsteady aerodynamics forces of a purely plunging airfoil 被引量:10
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作者 Chao ZHOU Yanlai ZHANG Jianghao WU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第1期88-101,共14页
Introducing flexibility into the design of a vertically flapping wing is an effective way to enhance its aerodynamic performance.As less previous studies on the aerodynamics of vertically flapping flexible wings focus... Introducing flexibility into the design of a vertically flapping wing is an effective way to enhance its aerodynamic performance.As less previous studies on the aerodynamics of vertically flapping flexible wings focused on the lift generated in a wide range of angle of attack·a 2D numerical simulation of a purely plunging flexible airfoil is employed using a loose fluid–structure interaction method.The aerodynamics of a fully flexible airfoil are firstly studied with the flexibility and angle of attack.To verify whether an airfoil could get aerodynamic benefit from the change in structure,partially flexible airfoil with rigid leading edge and flexible trailing edge were further considered.Results show that flexibility could always reduce airfoil drag while lift and lift efficiency both peak at moderate flexibility.When freestream velocity is constant,lift is maximized at a high angle of attack about 40°while this optimal angle of attack reduces to 15°in drag-balanced status.The airfoil drag reduction,lift augmentation as well as efficiency enhancement mainly attribute to the passive pitching other than the camber deformation.Partially deformed airfoil with the longest length of moderate flexible trailing edge can achieve the highest lift.This study may provide some guidance in the wing design of Micro Air Vehicle(MAV). 展开更多
关键词 Aerodynamic FORCES FLEXIBILITY Fluid structure interaction Low REYNOLDS NUMBER Plunging AIRFOIL self-propulsion
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喷水推进高速三体滑行艇数值自航研究 被引量:9
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作者 仝博 王永生 +1 位作者 杨琼方 刘承江 《船舶力学》 EI CSCD 北大核心 2018年第7期789-796,共8页
为了验证计算流体力学(CFD)方法预报滑行艇自由液面粘性流场的精确度,判断为某三体滑行艇设计的喷水推进器能否满足快速性要求,采用CFD方法对某喷水推进高速(1<Fr_L<1.8)三体滑行艇进行两相流的数值自航,并与试验值比较。运用切... 为了验证计算流体力学(CFD)方法预报滑行艇自由液面粘性流场的精确度,判断为某三体滑行艇设计的喷水推进器能否满足快速性要求,采用CFD方法对某喷水推进高速(1<Fr_L<1.8)三体滑行艇进行两相流的数值自航,并与试验值比较。运用切割体网格技术并基于RANS VOF求解,首先计算了五个不同速度下的裸艇阻力。结果表明:阻力系数最大误差8.3%,最小误差0.5%,达到了较好的计算精度;采用等推力系数法,在模型尺度下进行"滑行艇+喷泵"的数值自航,将结果推算到实尺度艇,结果表明该喷泵可以达到设计航速;高速航行时推力减额为负的主要原因是艇首尾压差阻力的显著降低。计算结果显示,考虑自由液面时滑行艇底部会出现不合理的水气分布,这影响到滑行艇的阻力性能和喷泵的推进性能,通过局部网格加密可以显著减少艇底非正常水气分布,但艇底气水层难以完全消除,这可能是CFD方法预报滑行艇阻力精度难以控制的原因之一。 展开更多
关键词 高速三体滑行艇 计算流体力学 阻力 自航 推力减额 水气分布
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Self-propulsion of flapping bodies in viscous fluids: Recent advances and perspectives 被引量:6
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作者 Shizhao Wang Guowei He Xing Zhang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2016年第6期980-990,共11页
Flapping-powered propulsion is used by many animals to locomote through air or water. Here we review recent experimental and numerical studies on self-propelled mechanical systems powered by a flapping motion. These s... Flapping-powered propulsion is used by many animals to locomote through air or water. Here we review recent experimental and numerical studies on self-propelled mechanical systems powered by a flapping motion. These studies improve our understanding of the mutual interaction between actively flapping bodies and surrounding fluids. The results obtained in these works provide not only new insights into biolocomotion but also useful information for the biomimetic design of artificial flyers and swimmers. 展开更多
关键词 Flapping motion self-propulsion Symmetry breaking Passive flexibility Flow-mediated interaction
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Self-propulsion of a three-dimensional flapping flexible plate 被引量:5
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作者 唐超 陆夕云 《Journal of Hydrodynamics》 SCIE EI CSCD 2016年第1期1-9,共9页
The self-propulsion of a 3-D flapping flexible plate in a stationary fluid is numerically studied by an immersed boundarylattice Boltzmann method for the fluid flow and a finite element method for the plate motion. Wh... The self-propulsion of a 3-D flapping flexible plate in a stationary fluid is numerically studied by an immersed boundarylattice Boltzmann method for the fluid flow and a finite element method for the plate motion. When the leading-edge of the plate is forced to heave sinusoidally, the entire plate starts to move freely as a result of the fluid-structure interaction. Based on our simulation and analysis on the dynamical behaviors of the flapping flexible plate, we have found that the effect of plate aspect ratio on its propulsive properties can be divided into three typical regimes which are related to the plate flexibility, i.e. stiff, medium flexible, and more flexible regime. It is also identified that a suitable structure flexibility, corresponding to the medium flexible regime, can improve the propulsive speed and efficiency. The wake behind the flapping plate is investigated for several aspect ratios to demonstrate some typical vortical structures. The results obtained in this study can provide some physical insights into the understanding of the propulsive mechanisms in the flapping-based locomotion. 展开更多
关键词 self-propulsion flapping-based locomotion flapping flexible plate flexibility effect propulsive efficiency
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基于阻力和自航数值模拟的内河邮轮线型优化
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作者 程保国 郝金凤 +1 位作者 强兆新 张成舜 《中国舰船研究》 CSCD 北大核心 2024年第3期217-223,共7页
[目的]基于阻力和自航数值模拟,以阻力和收到功率为优化目标,对一艘内河邮轮开展线型优化。[方法]首先进行船体艏部线型优化,以阻力为优化目标,基于艏部线型参数化变换和阻力CFD计算,得到优化船型1;然后开展船体艉部线型优化,以收到功... [目的]基于阻力和自航数值模拟,以阻力和收到功率为优化目标,对一艘内河邮轮开展线型优化。[方法]首先进行船体艏部线型优化,以阻力为优化目标,基于艏部线型参数化变换和阻力CFD计算,得到优化船型1;然后开展船体艉部线型优化,以收到功率为优化目标,通过艉部线型参数化变换、阻力和自航CFD计算,得到最终优化船型。[结果]CFD计算结果表明,相较于初始船型,最终优化船型的有效功率降低了5.17%,收到功率降低了7.11%。[结论]研究显示,所采用的优化方法能够有效改善船舶阻力和推进性能,可以推广应用到其他船型的线型优化。 展开更多
关键词 阻力 自航 数值模拟 内河邮轮 线型优化 参数化变换
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鲹科模式鱼体自主前游的标度律研究 被引量:2
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作者 高天宇 余永亮 鲍麟 《力学学报》 EI CAS CSCD 北大核心 2023年第4期858-873,共16页
鲹科鱼类采用波状摆动可以实现非常高效的巡游游动,在受力动态平衡下以很高的速度向前游动,其性能远超传统的人造水下航行器,因此,探寻鱼体自主前游状态下流体力和前游速度的规律并建立相应的预测式具有重要的意义.在开源OpenFOAM平台... 鲹科鱼类采用波状摆动可以实现非常高效的巡游游动,在受力动态平衡下以很高的速度向前游动,其性能远超传统的人造水下航行器,因此,探寻鱼体自主前游状态下流体力和前游速度的规律并建立相应的预测式具有重要的意义.在开源OpenFOAM平台和柔性体自主推进算法基础上,实现了波动鱼体自主游动的数值模拟,以NACA0012翼型为典型鱼体外形,对鲹科模式前向自主游动开展了系统的数值模拟.由已获得的栓结模型下推力标度律的启发,分别对自主巡游下的压差力系数和摩阻力系数进行标度研究.结果表明在雷诺数从500到50000的范围内,压差力系数和摩阻力系数分别具有形式一致的标度规律,由此可根据数值结果给出定量的预测公式,进而根据两作用力的匹配关系可以导出鱼体自主前游速度的标度律,获得了根据已知的鱼体波动参数来预估巡游速度的方法.此外,探讨了雷诺数为500和50000工况,不同摆尾幅度和频率组合下,鱼体厚弦比对于巡游的水动力标度律和前游速度的影响,并分析了不同鱼体外形对效能比的影响,发现雷诺数越高,获得最优效能比的鱼体越细长. 展开更多
关键词 自主推进 鲹科模式 标度律 前游速度 厚弦比
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基于CFD-PID方法的仿生鱼自推进运动研究
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作者 王鹏飞 李若欣 于凯 《水动力学研究与进展(A辑)》 CSCD 北大核心 2024年第1期104-108,共5页
相较于传统的螺旋桨推进方式,水下仿生推进具有灵活、高效及对环境干扰小等优势。该文在求解不可压N-S方程和牛顿第二定律的基础上,嵌入PID控制算法,构建CFD-PID求解器,模拟主动控制下的仿生鱼自推进运动。通过PID算法动态调节仿生鱼摆... 相较于传统的螺旋桨推进方式,水下仿生推进具有灵活、高效及对环境干扰小等优势。该文在求解不可压N-S方程和牛顿第二定律的基础上,嵌入PID控制算法,构建CFD-PID求解器,模拟主动控制下的仿生鱼自推进运动。通过PID算法动态调节仿生鱼摆幅,间接控制其速度,使仿生鱼可以达到任意特定的收敛速度。与常规方式自推进相比,PID控制自推进能更快地加速到预定速度,且在加速时期产生更大尺度的涡,最终的动态平衡状态则与常规方式自推进一致。 展开更多
关键词 仿生鱼 自推进 PID控制 BCF模式
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基于OpenFOAM的某双艉鳍船快速性能研究
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作者 邢磊 车霖源 高玉玲 《上海船舶运输科学研究所学报》 2024年第3期9-14,共6页
为研究双艉鳍船的艉鳍倾角和螺旋桨旋向对船舶快速性的影响,以OpenFOAM为工具,对模型尺度下的某双艉鳍船进行阻力和自航数值模拟,其中自航分为内旋和外旋2种工况。研究表明:与模型试验结果相比,阻力和自航数值计算结果的偏差均在3%以内... 为研究双艉鳍船的艉鳍倾角和螺旋桨旋向对船舶快速性的影响,以OpenFOAM为工具,对模型尺度下的某双艉鳍船进行阻力和自航数值模拟,其中自航分为内旋和外旋2种工况。研究表明:与模型试验结果相比,阻力和自航数值计算结果的偏差均在3%以内,精度较高;将垂直艉鳍改为倾斜艉鳍,能改善艉部流动,减小低速区范围、流动分离和船体阻力;艉鳍形式和旋向对船舶推进效率的影响主要体现在船身效率上,伴流均匀性是影响船舶推进效率的主要因素之一。研究采用的基于OpenFOAM的快速性分析方法可供其他类型船的优化设计参考。 展开更多
关键词 自航 阻力 双艉鳍 OpenFOAM平台 内旋 外旋
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Coupling of RANS and BEM Solvers for Simulation of Propeller Behind the Hull in Full Appended Model
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作者 Saeed NAJAFI Mehdi POURMOSTAFA LIU Peng-fei 《China Ocean Engineering》 SCIE EI CSCD 2024年第3期424-438,共15页
To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this pap... To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this paper,a coupled BEM(Boundary Element Method)/RANS(Renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion test.The motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational time.An unsteady boundary element method which is also known as panel method is chosen to estimate the propeller forces.Propeller wakes are treated using a time marching wake alignment method.Also,a RANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the RANS code.Based on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller RPM in every time step.Verification of the solver is carried out using the towing tank test report of a 50 m oceanography research vessel.Wake factor and trust deduction coefficient are estimated numerically.Also,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field. 展开更多
关键词 RANS BEM coupled method ship propeller self-propulsion wake sheet pattern
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Untethered Micro/Nanorobots for Remote Sensing:Toward Intelligent Platform
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作者 Qianqian Wang Shihao Yang Li Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第2期450-483,共34页
Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and d... Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities.Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to achieve.Over the past decade of development,significant research progress has been made in designing sensing strategies based on micro/nanorobots,employing various coordinated control and sensing approaches.This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment interactions.Providing recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications. 展开更多
关键词 Micro/nanorobot Remote sensing Wireless control self-propulsion Actuation at small scales
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Mesoporous silica as micro/nano-carrier: From passive to active cargo delivery, a mini review 被引量:4
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作者 Xing Ma Huanhuan Feng +3 位作者 Chunyan Liang Xiaojia Liu Fanyu Zeng Yong Wang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第10期1067-1074,共8页
Mesoporous silica has been widely explored for biomedical applications due to its unique structure and good biocompatibility. In particular it exhibits superior properties as micro/nano-carriers in the biomedical fiel... Mesoporous silica has been widely explored for biomedical applications due to its unique structure and good biocompatibility. In particular it exhibits superior properties as micro/nano-carriers in the biomedical field. We explore their potentials in controlled drug/gene co-delivery and photodynamic therapy for cancer treatment both in vitro and in vivo. By incorporating mesoporous silica nanoparticles(MSNP) with two-dimensional nanomaterial, graphene oxide nano-sheet, we utilize MSNP in cellular bio-imaging with squaraine dye. Meanwhile, through delicate combination between mesoporous silica micro/nano carriers with catalytic/bio-catalytic reactions, we manage to achieve self-propelled micro/nano-motors based on mesoporous silica that are capable of transporting cargos in an active manner. Especially, enzyme powered mesoporous silica motors can be powered by physiologically available fuels such as glucose and urea,which are advantageous for future biomedical use. Motion control on both velocity and movement direction provides a powerful tool for targeted drug delivery. Therefore, such mesoporous silica based active carriers pave way to the solution of targeted drug delivery for cancer treatment in future nano-medicine field. 展开更多
关键词 Mesoporous silica Micro/nano-carrier Drug delivery self-propulsion Active carrier
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基于第三代涡识别方法的极地邮轮自航流场中的涡结构分析 被引量:1
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作者 马云鹏 王建华 万德成 《水动力学研究与进展(A辑)》 CSCD 北大核心 2023年第4期505-514,共10页
在船舶航时产生的流场中,涡结构是无处不在的。自2017年兴起的Liutex方法对流体的局部刚体旋转进行了详细阐释,其中包括局部旋转轴和旋转强度,据此,涡量可分解为刚体旋转和纯剪切,可从流体运动中提取出刚体的旋转部分。对于不同的研究对... 在船舶航时产生的流场中,涡结构是无处不在的。自2017年兴起的Liutex方法对流体的局部刚体旋转进行了详细阐释,其中包括局部旋转轴和旋转强度,据此,涡量可分解为刚体旋转和纯剪切,可从流体运动中提取出刚体的旋转部分。对于不同的研究对象,第三代涡识别方法Liutex无需调整阈值,此外,ΩR方法还可识别强度不同的涡结构;通过使用Liutex方法,可以较为准确地描述各种涡的重要特征量,如涡核中心、涡流边界及绝对强度等。该文通过使用不同的涡识别方法,分析了极地邮轮自航流场中船体、舵周围以及旋转螺旋桨所产生的涡结构。 展开更多
关键词 极地邮轮 船舶自航 船桨舵相互作用 涡结构 Liutex
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近冰脊航行潜艇自推进水动力特性研究 被引量:1
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作者 孙盛 石玉云 李志富 《中国造船》 EI CSCD 北大核心 2023年第2期82-94,共13页
为了掌握冰脊对潜艇近冰面航行时水动力特性的影响,针对带有KP505螺旋桨的SUBOFF潜艇模型,建立了由3组等间距冰脊组成的冰下航道近冰面流场,采用重叠网格与滑移网格相结合的自推进潜艇水动力研究方法,预报了带有KP505螺旋桨的全附体SUB... 为了掌握冰脊对潜艇近冰面航行时水动力特性的影响,针对带有KP505螺旋桨的SUBOFF潜艇模型,建立了由3组等间距冰脊组成的冰下航道近冰面流场,采用重叠网格与滑移网格相结合的自推进潜艇水动力研究方法,预报了带有KP505螺旋桨的全附体SUBOFF潜艇在连续冰脊下的自航特性,分析了冰脊与自航潜艇的水动力耦合特性。研究发现,相比于平整冰面,潜艇在连续冰脊下自航点的螺旋桨转速降低可达11%;潜艇近冰脊航行时阻力一直在均值附近不断波动,波动幅值约为均值的10%;潜艇经过冰脊下方时的表面压力系数增大,推力系数降低。 展开更多
关键词 冰脊 SUBOFF潜艇 KP505螺旋桨 自推进 耦合水动力
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The Calculations of Propeller Induced Velocity by RANS and Momentum Theory 被引量:5
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作者 Qiuxin Gao Wei Jin Dracos Vassalos 《Journal of Marine Science and Application》 2012年第2期164-168,共5页
In order to provide instructions for the calculation of the propeller induced velocity in the study of the hull-propeller interaction using the body force approach,three methods were used to calculate the propeller in... In order to provide instructions for the calculation of the propeller induced velocity in the study of the hull-propeller interaction using the body force approach,three methods were used to calculate the propeller induced velocity:1) Reynolds-Averaged Navier-Stokes(RANS) simulation of the self-propulsion test,2) RANS simulation of the propeller open water test,and 3) momentum theory of the propeller.The results from the first two methods were validated against experimental data to assess the accuracy of the computed flow field.The thrust identity method was adopted to obtain the advance velocity,which was then used to derive the propeller induced velocity from the total velocity field.The results computed by the first two approaches were close,while those from the momentum theory were significantly overestimated.The presented results could prove to be useful for further calculations of self-propulsion using the body force approach. 展开更多
关键词 propeller induced velocity RANS momentum theory self-propulsion
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Proliferation-mediated asymmetric nanoencapsulation of singlecell and motility differentiation
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作者 WANG ShengLiang XU ZhiJun +5 位作者 CHEN HaiXu WANG XiaoLiang LIN Song WANG Lei LIU XiaoMan HUANG Xin 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2023年第7期2134-2146,共13页
The biointerface engineering of living cells by creating an abiotic shell has important implications for endowing cells with exogenous properties with improved cellular behavior,which then boosts the development of th... The biointerface engineering of living cells by creating an abiotic shell has important implications for endowing cells with exogenous properties with improved cellular behavior,which then boosts the development of the emerging field of living cell hybrid materials.Herein,we develop a way to perform active nanoencapsulation of single cell,which then endows the encapsulated cells with motion ability that they do not inherently possess.The emerging motion characteristics of the encapsulated cells could be self-regulated in terms of both the motion velocity and orbits by different proliferation modes.Accordingly,by taking advantage of the emergence of differentiated moving abilities,we achieve the self-sorting between mother cells and daughter cells in a proliferated Saccharomyces cerevisiae cell community.Therefore,it is anticipated that our highlighted study could not only serve as a new technique in the field of single-cell biology analysis and sorting such as in studying the aging process in Saccharomyces cerevisiae,but also open up opportunities to manipulate cell functionality by creating biohybrid materials to fill the gap between biological systems and engineering abiotic materials. 展开更多
关键词 biointerface engineering MICROMOTORS self-propulsion self-SORTING UREASE
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基于实尺度船舶自航数值模拟的航速预报 被引量:3
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作者 张青山 陈伟民 +3 位作者 杜云龙 杨帆 陈昆鹏 任海奎 《中国造船》 EI CSCD 北大核心 2022年第5期11-21,共11页
准确预报船舶自航性能对船舶设计和优化有重要意义。论文应用计算流体力学(CFD)方法,并用体积力替代真实螺旋桨,对一艘散货船进行了实尺度自航数值模拟。基于螺旋桨收到功率引入PID控制,自动调整螺旋桨转速,以达到自航点。此外,采用3种... 准确预报船舶自航性能对船舶设计和优化有重要意义。论文应用计算流体力学(CFD)方法,并用体积力替代真实螺旋桨,对一艘散货船进行了实尺度自航数值模拟。基于螺旋桨收到功率引入PID控制,自动调整螺旋桨转速,以达到自航点。此外,采用3种不同的网格测试网格的不确定度。数值模拟结果与试验数据吻合良好,验证了该方法的有效性。 展开更多
关键词 实尺度 船舶自航 数值模拟 PID控制 航速预报
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典型散货船加装节能导管节能效果数值评估研究
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作者 金奕星 吴乘胜 余昕 《船舶力学》 EI CSCD 北大核心 2023年第7期959-973,共15页
节能效果的准确预报是船舶加装节能装置的重要依据,然而节能效果的评估涉及船体、节能装置、螺旋桨相互之间复杂的流动干扰问题,准确预报的难度很大。本文以国际标模JBC为对象,开展典型散货船加装节能导管前后节能效果数值评估研究。首... 节能效果的准确预报是船舶加装节能装置的重要依据,然而节能效果的评估涉及船体、节能装置、螺旋桨相互之间复杂的流动干扰问题,准确预报的难度很大。本文以国际标模JBC为对象,开展典型散货船加装节能导管前后节能效果数值评估研究。首先开展不同湍流模型、不同网格下加装节能导管前后的船模阻力数值计算,并对尾流场模拟结果进行分析,研究湍流模型和计算网格对计算结果的影响;随后开展JBC螺旋桨模型敞水性能数值计算,验证本文所采用计算方法可用于多体相对运动问题的数值模拟。基于上述研究,选取标准k-ε和RNG k-ε两种湍流模型开展船模加装节能导管前后的自航CFD模拟,并基于船模自航数值模拟结果预报出加装节能导管的节能效果与模型试验结果相当接近。研究工作表明,本文的CFD计算方法可以用于船舶加装节能导管节能效果的预报评估。 展开更多
关键词 节能导管 自航 螺旋桨敞水 交界面 数值评估
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癌症基因靶向治疗用高细胞摄取可注射纳米马达-水凝胶递送系统
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作者 任姣雨 王虹 《复合材料学报》 EI CAS CSCD 北大核心 2023年第3期1655-1662,共8页
小干扰RNA(siRNA)由于其降低基因表达的能力,通常在基因治疗中充当重要的治疗剂。然而,siRNA的低细胞摄取限制了其在癌症治疗中的功效。本文报告了一种生物相容的纳米马达-水凝胶递送系统,使siRNA可在癌症靶向治疗中获得高细胞摄取率。... 小干扰RNA(siRNA)由于其降低基因表达的能力,通常在基因治疗中充当重要的治疗剂。然而,siRNA的低细胞摄取限制了其在癌症治疗中的功效。本文报告了一种生物相容的纳米马达-水凝胶递送系统,使siRNA可在癌症靶向治疗中获得高细胞摄取率。首先通过层层自组装技术,以铂纳米粒子为核,使用聚乙烯亚胺(PEI)和聚苯乙烯磺酸钠(PSS)制备载有siRNA的纳米马达(NM)。为了瘤内给药和缓释,将纳米马达装载在席夫碱水凝胶中,构建NM-hydrogel系统。肿瘤微环境具有弱酸性和高H_(2)O_(2)含量的特点。水凝胶响应弱酸性微环境释放纳米马达,释放的纳米马达可以通过过氧化氢的催化分解实现自驱动,其运动速度在1wt%H_(2)O_(2)下为1.78μm/s(每秒约22.25个体长)。纳米马达的自驱动性能和由纳米马达上修饰的叶酸(FA)介导的特定内吞作用使NM-hydrogel系统具有63.8%的高细胞摄取率。同时,自驱动性能和PEI引起的质子海绵效应促进了纳米马达在肿瘤细胞中的深度渗透和长时间滞留,从而促进了NM-hydrogel系统的抗癌作用。结果表明:该体系在72 h时的抗癌活性为74.8%。同时,NM-hydrogel系统具有良好的生物相容性和生物降解性,为其未来在体内基因治疗中的应用奠定了基础。 展开更多
关键词 纳米粒子 自驱动 细胞摄取 水凝胶 基因疗法 癌症治疗
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加装节能导管的典型散货船自航CFD模拟与节能评估 被引量:3
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作者 余昕 吴乘胜 +1 位作者 金奕星 邱耿耀 《船舶》 2022年第5期48-58,共11页
节能效果的准确预报评估,对于船舶加装水动力节能装置而言非常重要。该文以国际标模JBC为对象,开展典型散货船加装节能导管的CFD计算分析研究:首先,开展了不同湍流模型、不同网格下带与不带节能导管的船模阻力数值计算,并对尾流场模拟... 节能效果的准确预报评估,对于船舶加装水动力节能装置而言非常重要。该文以国际标模JBC为对象,开展典型散货船加装节能导管的CFD计算分析研究:首先,开展了不同湍流模型、不同网格下带与不带节能导管的船模阻力数值计算,并对尾流场模拟结果进行了分析;然后,基于对船模阻力、流场计算结果的分析,选取了标准k-ε 和RNG k-ε 2种湍流模型开展了船模自航的CFD模拟;最后,基于自航模拟结果预报了加装节能导管的节能效果,与模型试验结果相当接近。研究表明,文中的CFD计算方法可以用于肥大型船舶加装节能导管的节能效果预报评估。 展开更多
关键词 节能导管 散货船 自航 计算流体动力学 标模JBC
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