The objective of this research will be to calculate the feasibility of investing in a solar energy generation project through the development of a methodology that allows the capture of environmental uncertainties by ...The objective of this research will be to calculate the feasibility of investing in a solar energy generation project through the development of a methodology that allows the capture of environmental uncertainties by improving decision making. The article presents a comparative study of the feasibility analysis of investment in a solar mini solar energy for a Shopping, considering a regime of certainty and uncertainty. The assumed stochastic variables were energy tariff and price of solar panels. The trajectories were simulated with the binomial approach that combined resulted in a quadratic diagram. The applied methodology presented the best recommendation and the option to wait was the most valuable. The exchange of the energy obtained from LIGHT by own generation of energy with solar photovoltaic source will be viable for the manager since it observes the behavior of the variables over time and follows the rules of optimal decision.展开更多
Incorporation of multiple functions into one nanoplatform can improve cancer diagnostic efficacy and enhance anti-cancer outcomes. Here, we constructed doxorubicin(DOX)-loaded silk fibroinbased nanoparticles(NPs) with...Incorporation of multiple functions into one nanoplatform can improve cancer diagnostic efficacy and enhance anti-cancer outcomes. Here, we constructed doxorubicin(DOX)-loaded silk fibroinbased nanoparticles(NPs) with surface functionalization by photosensitizer(N770). The obtained nanotheranostics(N770-DOX@NPs) had desirable particle size(157 nm) and negative surface charge(-25 m V). These NPs presented excellent oxygen-generating capacity and responded to a quadruple of stimuli(acidic solution, reactive oxygen species, glutathione, and hyperthermia). Surface functionalization of DOX@NPs with N770 could endow them with active internalization by cancerous cell lines, but not by normal cells. Furthermore, the intracellular NPs were found to be preferentially retained in mitochondria, which were also efficient for near-infrared(NIR) fluorescence imaging, photothermal imaging,and photoacoustic imaging. Meanwhile, DOX could spontaneously accumulate in the nucleus. Importantly, a mouse test group treated with N770-DOX@NPs plus NIR irradiation achieved the best tumorretardation effect among all treatment groups based on tumor-bearing mouse models and a patientderived xenograft model, demonstrating the unprecedented therapeutic effects of trimodal imagingguided mitochondrial phototherapy(photothermal therapy and photodynamic therapy) and chemotherapy.Therefore, the present study brings new insight into the exploitation of an easy-to-use, versatile, and robust nanoplatform for programmable targeting, imaging, and applying synergistic therapy to tumors.展开更多
Drilling results suggest that the thickness of natural gas hydrates(NGHs)in the Shenhu Area,South China Sea(SCS)are spatially heterogenous,making it difficult to accurately assess the NGHs resources in this area.In th...Drilling results suggest that the thickness of natural gas hydrates(NGHs)in the Shenhu Area,South China Sea(SCS)are spatially heterogenous,making it difficult to accurately assess the NGHs resources in this area.In the case that free gas exists beneath hydrate deposits,the frequency of the hydrate deposits will be noticeably attenuated,with the attenuation degree mainly affected by pore development and free gas content.Therefore,the frequency can be used as an important attribute to identify hydrate reservoirs.Based on the time-frequency characteristics of deposits,this study predicted the spatial distribution of hydrates in this area using the frequency division inversion method as follows.Firstly,the support vector machine(SVM)method was employed to study the amplitude versus frequency(AVF)response based on seismic and well logging data.Afterward,the AVF response was introduced as independent information to establish the nonlinear relationship between logging data and seismic waveform.Then,the full frequency band information of the seismic data was fully utilized to obtain the results of frequency division inversion.The inversion results can effectively broaden the frequency band,reflect the NGHs distribution,and reveal the NGHs reservoirs of two types,namely the fluid migration pathway type and the in situ self-generation self-storage diffusion type.Moreover,the inversion results well coincide with the drilling results.Therefore,it is feasible to use the frequency division inversion to predict the spatial distribution of heterogeneous NGHs reservoirs,which facilitates the optimization of favorable drilling targets and is crucial to the resource potential assessment of NGHs.展开更多
文摘The objective of this research will be to calculate the feasibility of investing in a solar energy generation project through the development of a methodology that allows the capture of environmental uncertainties by improving decision making. The article presents a comparative study of the feasibility analysis of investment in a solar mini solar energy for a Shopping, considering a regime of certainty and uncertainty. The assumed stochastic variables were energy tariff and price of solar panels. The trajectories were simulated with the binomial approach that combined resulted in a quadratic diagram. The applied methodology presented the best recommendation and the option to wait was the most valuable. The exchange of the energy obtained from LIGHT by own generation of energy with solar photovoltaic source will be viable for the manager since it observes the behavior of the variables over time and follows the rules of optimal decision.
基金supported by the National Natural Science Foundation of China(82072060,81773685,and 81571807)the Fundamental Research Funds for the Central Universities(XDJK2019TY002,China)+3 种基金the Chengdu Science and Technology Program(2018-CY02-00042-GX,China)the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYYC21002,ZYJC18032 and ZY2016101,China)the Natural Scienceof Chongqing(cstc2020jcyj-msxm X0292,China)the Venture&Innovation Support Program for Chongqing Overseas Returnees(cx2018029,China)。
文摘Incorporation of multiple functions into one nanoplatform can improve cancer diagnostic efficacy and enhance anti-cancer outcomes. Here, we constructed doxorubicin(DOX)-loaded silk fibroinbased nanoparticles(NPs) with surface functionalization by photosensitizer(N770). The obtained nanotheranostics(N770-DOX@NPs) had desirable particle size(157 nm) and negative surface charge(-25 m V). These NPs presented excellent oxygen-generating capacity and responded to a quadruple of stimuli(acidic solution, reactive oxygen species, glutathione, and hyperthermia). Surface functionalization of DOX@NPs with N770 could endow them with active internalization by cancerous cell lines, but not by normal cells. Furthermore, the intracellular NPs were found to be preferentially retained in mitochondria, which were also efficient for near-infrared(NIR) fluorescence imaging, photothermal imaging,and photoacoustic imaging. Meanwhile, DOX could spontaneously accumulate in the nucleus. Importantly, a mouse test group treated with N770-DOX@NPs plus NIR irradiation achieved the best tumorretardation effect among all treatment groups based on tumor-bearing mouse models and a patientderived xenograft model, demonstrating the unprecedented therapeutic effects of trimodal imagingguided mitochondrial phototherapy(photothermal therapy and photodynamic therapy) and chemotherapy.Therefore, the present study brings new insight into the exploitation of an easy-to-use, versatile, and robust nanoplatform for programmable targeting, imaging, and applying synergistic therapy to tumors.
基金supported by the National Research and Development Fund entitled“High Precision Characterization Technology of Natural Gas Hydrates Reservoirs”(2017YFC0307406)the projects entitled“Integrated Observation Data Integration and Application Service of Natural Resource Elements”(DD20208067)+2 种基金“Comprehensive geological survey of coastal zone and reef in the Northern Jiaodong”(ZD20220604)initiated by the China Geological Surveythe project entitled“Study on Hydrocarbon Accumulation Failure and Fluid Evolution Reduction of the Permian Reservoir in the Laoshan Uplift,South Yellow Sea”(42076220)“Temporal and Spatial Distribution Characteristics and Provenance of Two Stages Paleo-deltas on the Outer Shelf in the North of the East China Sea since Late Pleistocene”(41706069)organized by the National Natural Science Foundation of China。
文摘Drilling results suggest that the thickness of natural gas hydrates(NGHs)in the Shenhu Area,South China Sea(SCS)are spatially heterogenous,making it difficult to accurately assess the NGHs resources in this area.In the case that free gas exists beneath hydrate deposits,the frequency of the hydrate deposits will be noticeably attenuated,with the attenuation degree mainly affected by pore development and free gas content.Therefore,the frequency can be used as an important attribute to identify hydrate reservoirs.Based on the time-frequency characteristics of deposits,this study predicted the spatial distribution of hydrates in this area using the frequency division inversion method as follows.Firstly,the support vector machine(SVM)method was employed to study the amplitude versus frequency(AVF)response based on seismic and well logging data.Afterward,the AVF response was introduced as independent information to establish the nonlinear relationship between logging data and seismic waveform.Then,the full frequency band information of the seismic data was fully utilized to obtain the results of frequency division inversion.The inversion results can effectively broaden the frequency band,reflect the NGHs distribution,and reveal the NGHs reservoirs of two types,namely the fluid migration pathway type and the in situ self-generation self-storage diffusion type.Moreover,the inversion results well coincide with the drilling results.Therefore,it is feasible to use the frequency division inversion to predict the spatial distribution of heterogeneous NGHs reservoirs,which facilitates the optimization of favorable drilling targets and is crucial to the resource potential assessment of NGHs.
