By investigating a stochastic model for intracellular calcium oscillations proposed by Hfer,we have analyzed the transmission behavior of calcium signaling in a one-dimensional two-way coupled hepatocytes system.It ...By investigating a stochastic model for intracellular calcium oscillations proposed by Hfer,we have analyzed the transmission behavior of calcium signaling in a one-dimensional two-way coupled hepatocytes system.It is shown that when the first cell is subjected to the external noise,the output signal-to-noise ratio(SNR) in the cell exhibits two maxima as a function of external noise intensity,indicating the occurrence of stochastic bi-resonance(SBR).It is more important that when cells are coupled together,the resonant behavior in the 1st cell propagates along the chain with different features through the coupling effect.The cells whose locations are comparatively close to or far from the 1st cell can show SBR,while the cells located in the middle position can display stochastic multi-resonance(SMR).Fur-thermore,the number of cells that can show SMR increases with coupling strength enhancing.These results indicate that the cells system may make an effective choice in response to external signaling induced by noise,through the mechanism of SMR by adjusting coupling strength.展开更多
基金the Research Fund of Anhui Normal University(Grant No.2006xzx09)the Educational Commission of Anhui Province of China(Grant No.KJ2007A079)the Program for Innovative Research Team in Anhui Normal University
文摘By investigating a stochastic model for intracellular calcium oscillations proposed by Hfer,we have analyzed the transmission behavior of calcium signaling in a one-dimensional two-way coupled hepatocytes system.It is shown that when the first cell is subjected to the external noise,the output signal-to-noise ratio(SNR) in the cell exhibits two maxima as a function of external noise intensity,indicating the occurrence of stochastic bi-resonance(SBR).It is more important that when cells are coupled together,the resonant behavior in the 1st cell propagates along the chain with different features through the coupling effect.The cells whose locations are comparatively close to or far from the 1st cell can show SBR,while the cells located in the middle position can display stochastic multi-resonance(SMR).Fur-thermore,the number of cells that can show SMR increases with coupling strength enhancing.These results indicate that the cells system may make an effective choice in response to external signaling induced by noise,through the mechanism of SMR by adjusting coupling strength.
