Background Features of necrotic lesions and various interventions could affect the biomechanics of the femoral head. A three-dimensional finite-element analysis was designed to demonstrate necrotic femoral head stress...Background Features of necrotic lesions and various interventions could affect the biomechanics of the femoral head. A three-dimensional finite-element analysis was designed to demonstrate necrotic femoral head stress changes with various sizes of necrotic lesions, and evaluate the effect of tantalum rods on preventing femoral head cracking. Methods Femoral computed tomography scans were used to build a normal three-dimensional finite-element femoral head model in a computer. Based on the normal model, necrotic models of different lesion diameters （15 mm, 20 mm and 30 mm） were created, as were the repaired models with tantalum rods for each diameter. After a series of meshing and force loading, the von Mises stress distributions, simulating single-legged stance, and stresses on specific points under loaded conditions were determined for each model. Results Deep exploration into the burdened area of the femoral head indicated that higher stresses to the femoral head were observed with a larger necrotic lesion; the largest stress concentration, 91.3 MPa, was found on the femoral head with a lesion diameter of 30 mm. By contrast, topical stress on the surface of the necrotic regions was lowered following implantation of a tantalum rod, and the changes in stress were significant in models with lesions of 15 mm and 30 mm in diameter, with the best biomechanical benefit from the tantalum rod found with a lesion diameter of 15 mm. Conclusions Femoral heads with larger necrotic lesions usually have a higher stress concentration and a higher risk of collapse. Various sized lesions on the femoral head can benefit from the mechanical support offered by the implantation of a tantalum rod; however, femoral heads with smaller sized lesions may benefit more. A thorough evaluation of the lesion size should be conducted prior to the use of tantalum rod implants in the treatment of femoral head necrosis.展开更多
A general nonlinear constitutive model is proposed for magnetostrictive materials, based on the important physical fact that a nonlinear part of the elastic strain produced by a pre-stress is related to the magnetic d...A general nonlinear constitutive model is proposed for magnetostrictive materials, based on the important physical fact that a nonlinear part of the elastic strain produced by a pre-stress is related to the magnetic domain rotation or movement and is responsible for the change of the maximum magnetostrictive strain with the pre-stress. To avoid the complicity of determining the tensor function describing the nonlinear elastic strain part, this paper proposes a simplified model by means of linearizing the nonlinear function. For the convenience of engineering applications, the expressions of the 3-D （bulk）, 2-D （film） and 1-D （rod） models are, respectively, given for an isotropic material and their applicable ranges are also discussed. By comparison with the experimental data of a Terfenol-D rod, it is found that the proposed model can accurately predict the magnetostrictive strain curves in low, moderate and high magnetic field regions for various compressive pre-stress levels. The numerical simulation further illustrates that, for either magnetostrictive rods or thin films, the proposed model can effectively describe the effects of the pre-stress or residual stress on the magnetization and magnetostrictive strain curves, while none of the known models can capture all of them. Therefore, the proposed model enjoys higher precision and wider applicability than the previous models, especially in the region of the high field.展开更多
We report the direct synthesis of ZnC0204 and ZnO/ZnC0204 submicron rod arrays grown on Ni foil current collectors via an ammonia-evaporation-induced method by controlling the ratio of Zn to Co. These three-dimension...We report the direct synthesis of ZnC0204 and ZnO/ZnC0204 submicron rod arrays grown on Ni foil current collectors via an ammonia-evaporation-induced method by controlling the ratio of Zn to Co. These three-dimensional （3D） hierar- chical self-supported nanostructures are composed of one-dimensional （1D） ZnCo204 rods and two-dimensional （2D） ZnO nanosheet bands perpendicular to the axis of the each ZnCo204 rod. We carefully deal with the heteroepitaxial growth mechanisms of hexagonal ZnO nanosheets from a crystallographic point of view. Furthermore, we demonstrate the ability of these high-surface-area ZnO/ZnCo204 heterostructured rods to enable improved electrolyte permeability and Li ion transfer, thereby enhancing their Li storage capability （-900 mA.h.g-1 at a rate of 45 mA.h.g-1） for Li ion battery electrodes.展开更多
In this paper,we review computational approaches to optimization problems of inhomogeneous rods and plates.We consider both the optimization of eigenvalues and the localization of eigenfunctions.These problems are mot...In this paper,we review computational approaches to optimization problems of inhomogeneous rods and plates.We consider both the optimization of eigenvalues and the localization of eigenfunctions.These problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration displacement.We demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.展开更多
Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band gap.Despi...Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band gap.Despite the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature adaptability.The optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these issues.The Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature adaptability.The complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium storage.Moreover,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.展开更多
Silica particles with rod-like and top-like morphologies have been controllably synthesized with a basic medium. The characteristics of the mesoporous silica particles were characterized by X-ray diffraction (XRD), ni...Silica particles with rod-like and top-like morphologies have been controllably synthesized with a basic medium. The characteristics of the mesoporous silica particles were characterized by X-ray diffraction (XRD), nitrogen sorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and high resolution transmission electron microscopy (HRTEM). The results indicate that temperature affects the macrostructures and mesostructure ordering of mesoporous silica. At lower temperature highly ordered mesoporous silica with hexastyle and top structure could be obtained under different alkalinity. As the temperature increases, mesoporous silica transforms to a rod-like shape and the aspect ratio of length/diameter decreases with the decrease of the order of mesostructure. When the temperature is high enough, spherical particles could be prepared and there are still defects existing in mesostructure.展开更多
The Near-Surface Mounted(NSM)strengthening technique has emerged as a promising alternative to traditional strengthening methods in recent years.Over the past two decades,researchers have extensively studied its poten...The Near-Surface Mounted(NSM)strengthening technique has emerged as a promising alternative to traditional strengthening methods in recent years.Over the past two decades,researchers have extensively studied its potential,advantages,and applications,as well as related parameters,aiming at optimization of construction systems.However,there is still a need to explore further,both from a static perspective,which involves accounting for the nonconservation of the contact section resulting from the bond-slip effect between fiber-reinforced polymer(FRP)rods and resin and is typically neglected by existing analytical models,as well as from a dynamic standpoint,which involves studying the trends of vibration frequencies to understand the effects of various forms of damage and the efficiency of reinforcement.To address this gap in knowledge,this research involves static and dynamic tests on simply supported reinforced concrete(RC)beams using rods of NSM carbon fiber reinforced polymer(CFRP)and glass fiber reinforced polymer(GFRP).The main objective is to examine the effects of various strengthening methods.This research conducts bending tests with loading cycles until failure,and it helps to define the behavior of beam specimens under various damage degrees,including concrete cracking.Dynamic analysis by free vibration testing enables tracking of the effectiveness of the reinforcement at various damage levels at each stage of the loading process.In addition,application of Particle Swarm Optimization(PSO)and Genetic Algorithm(GA)is proposed to optimize Gradient Boosting(GB)training performance for concrete strain prediction in NSM-FRP RC.The GB using Particle Swarm Optimization(GBPSO)and GB using Genetic Algorithm(GBGA)systems were trained using an experimental data set,where the input data was a static applied load and the output data was the consequent strain.Hybrid models of GBPSO and GBGA have been shown to provide highly accurate results for predicting strain.These models combine the strengths of both optimization tec展开更多
Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effe...Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon.展开更多
Unsteady wake from upstream components of landing gear impinging on downstream components could be a strong noise source.The use of a plane jet is proposed to reduce this flow-induced noise.Tandem rods with different ...Unsteady wake from upstream components of landing gear impinging on downstream components could be a strong noise source.The use of a plane jet is proposed to reduce this flow-induced noise.Tandem rods with different gap widths were utilized as the test body.Both acoustic and aerodynamic tests were conducted in order to validate this technique.Acoustic test results proved that overall noise emission from tandem rods could be lowered and tonal noise could be removed with use of the plane jet.However,when the plane jet was turned on,in some frequency range it could be the subsequent main contributor instead of tandem rods to total noise emission whilst in some frequency range rods could still be the main contributor.Moreover,aerodynamic tests fundamentally studied explanations for the noise reduction.Specifically,not only impinging speed to rods but speed and turbulence level to the top edge of the rear rod could be diminished by the upstream plane jet.Consequently,the vortex shedding induced by the rear rod was reduced,which was confirmed by the speed,Reynolds stress as well as the velocity fluctuation spectral measured in its wake.This study confirmed the potential use of a plane jet towards landing gear noise reduction.展开更多
Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fac...Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain unclear.The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment.This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly.In this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during neuroinflammation.We also discuss other factors contributing to brain aging and neuroinflammation.展开更多
Treatment paradigms for Early Onset Scoliosis have changed from fusion to fusionless methods as the harmful effects of early fusion on the growing spine and thorax were realized. Magnetic rods are a recent addition to...Treatment paradigms for Early Onset Scoliosis have changed from fusion to fusionless methods as the harmful effects of early fusion on the growing spine and thorax were realized. Magnetic rods are a recent addition to fusionless technology for controlling scoliosis in a growing spine. The clinical evidence base on magnet driven growth rods(MDGR) has accumulated over the last 4 years. It has implications for reduction in the number of repeat surgeries required with similar complications as the traditional growth rods(TGR) and at a higher initial cost. However in terms of patient psyche and avoidance of repeat surgeries which are necessary with the TGR, MDGR treatment works out less expensive in the long run with definitely better patient comfort. The authors look at the available literature coupled with their own experience to discuss the current status, limitations and future prospects for this type of technology.展开更多
The anisotropic absorption and emission from semiconductor CdSe/CdS quantum rods(QRs)provide extra benefits among other photoluminescence nanocrystals.Using photo-induced alignment technique,the QRs can be oriented in...The anisotropic absorption and emission from semiconductor CdSe/CdS quantum rods(QRs)provide extra benefits among other photoluminescence nanocrystals.Using photo-induced alignment technique,the QRs can be oriented in liquid crystal polymer matrix at a large scale.In this article,a 2D Dammann grating pattern,within“SKL”characters domains aligned QRs in composite film,was fabricated by multi-step photo exposure using several photo masks,and a continuous geometric lens profile pattern aligned QRs was realized by the single step polarization converting holographic irradiation method.Both polarized optical microscope and fluorescence microscope are employed to determine the liquid crystal director profiles and QRs anisotropic excitation properties.We have been able to orient the QRs in fine binary and continuous patterns that confirms the strong quantum rod aligning ability of the proposed method.Thus,the proposed approach paves a way for photoinduced flexible QRs alignments to provide a highly specific and difficult-to-replicate security application at a large scale.展开更多
文摘Background Features of necrotic lesions and various interventions could affect the biomechanics of the femoral head. A three-dimensional finite-element analysis was designed to demonstrate necrotic femoral head stress changes with various sizes of necrotic lesions, and evaluate the effect of tantalum rods on preventing femoral head cracking. Methods Femoral computed tomography scans were used to build a normal three-dimensional finite-element femoral head model in a computer. Based on the normal model, necrotic models of different lesion diameters （15 mm, 20 mm and 30 mm） were created, as were the repaired models with tantalum rods for each diameter. After a series of meshing and force loading, the von Mises stress distributions, simulating single-legged stance, and stresses on specific points under loaded conditions were determined for each model. Results Deep exploration into the burdened area of the femoral head indicated that higher stresses to the femoral head were observed with a larger necrotic lesion; the largest stress concentration, 91.3 MPa, was found on the femoral head with a lesion diameter of 30 mm. By contrast, topical stress on the surface of the necrotic regions was lowered following implantation of a tantalum rod, and the changes in stress were significant in models with lesions of 15 mm and 30 mm in diameter, with the best biomechanical benefit from the tantalum rod found with a lesion diameter of 15 mm. Conclusions Femoral heads with larger necrotic lesions usually have a higher stress concentration and a higher risk of collapse. Various sized lesions on the femoral head can benefit from the mechanical support offered by the implantation of a tantalum rod; however, femoral heads with smaller sized lesions may benefit more. A thorough evaluation of the lesion size should be conducted prior to the use of tantalum rod implants in the treatment of femoral head necrosis.
基金The project supported by the National Natural Science Foundation of China(10132010 and 90405005 )
文摘A general nonlinear constitutive model is proposed for magnetostrictive materials, based on the important physical fact that a nonlinear part of the elastic strain produced by a pre-stress is related to the magnetic domain rotation or movement and is responsible for the change of the maximum magnetostrictive strain with the pre-stress. To avoid the complicity of determining the tensor function describing the nonlinear elastic strain part, this paper proposes a simplified model by means of linearizing the nonlinear function. For the convenience of engineering applications, the expressions of the 3-D （bulk）, 2-D （film） and 1-D （rod） models are, respectively, given for an isotropic material and their applicable ranges are also discussed. By comparison with the experimental data of a Terfenol-D rod, it is found that the proposed model can accurately predict the magnetostrictive strain curves in low, moderate and high magnetic field regions for various compressive pre-stress levels. The numerical simulation further illustrates that, for either magnetostrictive rods or thin films, the proposed model can effectively describe the effects of the pre-stress or residual stress on the magnetization and magnetostrictive strain curves, while none of the known models can capture all of them. Therefore, the proposed model enjoys higher precision and wider applicability than the previous models, especially in the region of the high field.
文摘We report the direct synthesis of ZnC0204 and ZnO/ZnC0204 submicron rod arrays grown on Ni foil current collectors via an ammonia-evaporation-induced method by controlling the ratio of Zn to Co. These three-dimensional （3D） hierar- chical self-supported nanostructures are composed of one-dimensional （1D） ZnCo204 rods and two-dimensional （2D） ZnO nanosheet bands perpendicular to the axis of the each ZnCo204 rod. We carefully deal with the heteroepitaxial growth mechanisms of hexagonal ZnO nanosheets from a crystallographic point of view. Furthermore, we demonstrate the ability of these high-surface-area ZnO/ZnCo204 heterostructured rods to enable improved electrolyte permeability and Li ion transfer, thereby enhancing their Li storage capability （-900 mA.h.g-1 at a rate of 45 mA.h.g-1） for Li ion battery electrodes.
基金supported by the DMS-1853701supported in part by the DMS-2208373.
文摘In this paper,we review computational approaches to optimization problems of inhomogeneous rods and plates.We consider both the optimization of eigenvalues and the localization of eigenfunctions.These problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration displacement.We demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.
基金financially supported by the National Natural Science Foundation of China(No.22175103)Young Taishan Scholar project of Shandong province。
文摘Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band gap.Despite the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature adaptability.The optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these issues.The Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature adaptability.The complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium storage.Moreover,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.
文摘Silica particles with rod-like and top-like morphologies have been controllably synthesized with a basic medium. The characteristics of the mesoporous silica particles were characterized by X-ray diffraction (XRD), nitrogen sorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and high resolution transmission electron microscopy (HRTEM). The results indicate that temperature affects the macrostructures and mesostructure ordering of mesoporous silica. At lower temperature highly ordered mesoporous silica with hexastyle and top structure could be obtained under different alkalinity. As the temperature increases, mesoporous silica transforms to a rod-like shape and the aspect ratio of length/diameter decreases with the decrease of the order of mesostructure. When the temperature is high enough, spherical particles could be prepared and there are still defects existing in mesostructure.
文摘The Near-Surface Mounted(NSM)strengthening technique has emerged as a promising alternative to traditional strengthening methods in recent years.Over the past two decades,researchers have extensively studied its potential,advantages,and applications,as well as related parameters,aiming at optimization of construction systems.However,there is still a need to explore further,both from a static perspective,which involves accounting for the nonconservation of the contact section resulting from the bond-slip effect between fiber-reinforced polymer(FRP)rods and resin and is typically neglected by existing analytical models,as well as from a dynamic standpoint,which involves studying the trends of vibration frequencies to understand the effects of various forms of damage and the efficiency of reinforcement.To address this gap in knowledge,this research involves static and dynamic tests on simply supported reinforced concrete(RC)beams using rods of NSM carbon fiber reinforced polymer(CFRP)and glass fiber reinforced polymer(GFRP).The main objective is to examine the effects of various strengthening methods.This research conducts bending tests with loading cycles until failure,and it helps to define the behavior of beam specimens under various damage degrees,including concrete cracking.Dynamic analysis by free vibration testing enables tracking of the effectiveness of the reinforcement at various damage levels at each stage of the loading process.In addition,application of Particle Swarm Optimization(PSO)and Genetic Algorithm(GA)is proposed to optimize Gradient Boosting(GB)training performance for concrete strain prediction in NSM-FRP RC.The GB using Particle Swarm Optimization(GBPSO)and GB using Genetic Algorithm(GBGA)systems were trained using an experimental data set,where the input data was a static applied load and the output data was the consequent strain.Hybrid models of GBPSO and GBGA have been shown to provide highly accurate results for predicting strain.These models combine the strengths of both optimization tec
基金Supported by Brazilian government research foundations National Council for Research and Technology and Coordination for the Improvement of Higher Education Personnel with research grant and scholarships processNo.9028-11-0+2 种基金No.305064/2011-8 and No.232711/2014-3Sao Paulo Government agency Sao Paulo State Research Foundation withprocess No.2011/12448-0both granted to Andrade LEC and Keppeke GD
文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon.
基金Project partially supported by the European Union FP7 Clean Sky Joint Technology Initiative“ALLEGRA”(Grant No.308225)
文摘Unsteady wake from upstream components of landing gear impinging on downstream components could be a strong noise source.The use of a plane jet is proposed to reduce this flow-induced noise.Tandem rods with different gap widths were utilized as the test body.Both acoustic and aerodynamic tests were conducted in order to validate this technique.Acoustic test results proved that overall noise emission from tandem rods could be lowered and tonal noise could be removed with use of the plane jet.However,when the plane jet was turned on,in some frequency range it could be the subsequent main contributor instead of tandem rods to total noise emission whilst in some frequency range rods could still be the main contributor.Moreover,aerodynamic tests fundamentally studied explanations for the noise reduction.Specifically,not only impinging speed to rods but speed and turbulence level to the top edge of the rear rod could be diminished by the upstream plane jet.Consequently,the vortex shedding induced by the rear rod was reduced,which was confirmed by the speed,Reynolds stress as well as the velocity fluctuation spectral measured in its wake.This study confirmed the potential use of a plane jet towards landing gear noise reduction.
基金supported by Fellowship from Saudi Arabia Cultural Mission,College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia
文摘Aging brain becomes susceptible to neurodegenerative diseases due to the shifting of microglia and astrocyte phenotypes to an active“pro-inflammatory”state,causing chronic low-grade neuroinflammation.Despite the fact that the role of neuroinflammation during aging has been extensively studied in recent years,the underlying causes remain unclear.The identification of relevant proteins and understanding their potential roles in neuroinflammation can help explain their potential of becoming biomarkers in the aging brain and as drug targets for prevention and treatment.This will eventually reduce the chances of developing neurodegenerative diseases and promote healthier lives in the elderly.In this review,we have summarized the morphological and cellular changes in the aging brain,the effects of age-related neuroinflammation,and the potential role of cofilin-1 during neuroinflammation.We also discuss other factors contributing to brain aging and neuroinflammation.
文摘Treatment paradigms for Early Onset Scoliosis have changed from fusion to fusionless methods as the harmful effects of early fusion on the growing spine and thorax were realized. Magnetic rods are a recent addition to fusionless technology for controlling scoliosis in a growing spine. The clinical evidence base on magnet driven growth rods(MDGR) has accumulated over the last 4 years. It has implications for reduction in the number of repeat surgeries required with similar complications as the traditional growth rods(TGR) and at a higher initial cost. However in terms of patient psyche and avoidance of repeat surgeries which are necessary with the TGR, MDGR treatment works out less expensive in the long run with definitely better patient comfort. The authors look at the available literature coupled with their own experience to discuss the current status, limitations and future prospects for this type of technology.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030009)the National Natural Science Foundation of China(Nos.62005180,61935013)+2 种基金the Zhejiang Lab Open Research Project(No.K2022MG0AB01)RGC of Hong Kong S.A.R.(No.26202019)the State Key Laboratory of Advanced Displays and Optoelectronics Technologies(HKUST)(No.ITC-PSKL12EG02)。
文摘The anisotropic absorption and emission from semiconductor CdSe/CdS quantum rods(QRs)provide extra benefits among other photoluminescence nanocrystals.Using photo-induced alignment technique,the QRs can be oriented in liquid crystal polymer matrix at a large scale.In this article,a 2D Dammann grating pattern,within“SKL”characters domains aligned QRs in composite film,was fabricated by multi-step photo exposure using several photo masks,and a continuous geometric lens profile pattern aligned QRs was realized by the single step polarization converting holographic irradiation method.Both polarized optical microscope and fluorescence microscope are employed to determine the liquid crystal director profiles and QRs anisotropic excitation properties.We have been able to orient the QRs in fine binary and continuous patterns that confirms the strong quantum rod aligning ability of the proposed method.Thus,the proposed approach paves a way for photoinduced flexible QRs alignments to provide a highly specific and difficult-to-replicate security application at a large scale.
