药品质量源于设计(Quality by Design,QbD)鼓励采用创新制药工艺、技术和装备提高药品质量和生产效率。连续制造(Continuous Manufacturing)指在一段时间内不间断提供原料并生产出终产品的过程。与间歇(Batch)生产相比,连续制造具有占...药品质量源于设计(Quality by Design,QbD)鼓励采用创新制药工艺、技术和装备提高药品质量和生产效率。连续制造(Continuous Manufacturing)指在一段时间内不间断提供原料并生产出终产品的过程。与间歇(Batch)生产相比,连续制造具有占地面积少、生产周期缩短、智能化程度高、工艺易放大、产品质量一致性高等特点,符合未来药品生产发展趋势和需求。本文总结了连续制药过程关键技术和方法,包括连续喂料、连续混合、连续制粒等单元型连续制药过程,以及口服固体制剂、化学药合成和生物制品的全程型连续生产过程,介绍了停留时间分布分布(RTD)模型和过程分析技术(PAT)等先进控制方法在连续制药过程中的应用,以期对我国药品和中药生产的发展提供借鉴。展开更多
Systems that have big transmission line may have problem on changes of pressure in the distribution system. Because the increase in water age is dependent on the difference between the production and consumption rates...Systems that have big transmission line may have problem on changes of pressure in the distribution system. Because the increase in water age is dependent on the difference between the production and consumption rates, high residence time in pipes and storage duration in water tanks. The goal of this study is to analyze the effects residence time to water quality in large water distribution systems. According to the results in Ahwaz, bacterial growth (HPC) has a direct relationship with water age, and changing rate of the bacterial growth (HPC) and the distance travelled and residence time have been caused to increase water age, bacterial growth (HPC), chlorine consumption and hydraulic change. So bacterial growth (HPC) doesn’t have any relationship with THMs and Tol Coli form, but has a reversed relationship with residual chlorine nearly.展开更多
文摘药品质量源于设计(Quality by Design,QbD)鼓励采用创新制药工艺、技术和装备提高药品质量和生产效率。连续制造(Continuous Manufacturing)指在一段时间内不间断提供原料并生产出终产品的过程。与间歇(Batch)生产相比,连续制造具有占地面积少、生产周期缩短、智能化程度高、工艺易放大、产品质量一致性高等特点,符合未来药品生产发展趋势和需求。本文总结了连续制药过程关键技术和方法,包括连续喂料、连续混合、连续制粒等单元型连续制药过程,以及口服固体制剂、化学药合成和生物制品的全程型连续生产过程,介绍了停留时间分布分布(RTD)模型和过程分析技术(PAT)等先进控制方法在连续制药过程中的应用,以期对我国药品和中药生产的发展提供借鉴。
文摘Systems that have big transmission line may have problem on changes of pressure in the distribution system. Because the increase in water age is dependent on the difference between the production and consumption rates, high residence time in pipes and storage duration in water tanks. The goal of this study is to analyze the effects residence time to water quality in large water distribution systems. According to the results in Ahwaz, bacterial growth (HPC) has a direct relationship with water age, and changing rate of the bacterial growth (HPC) and the distance travelled and residence time have been caused to increase water age, bacterial growth (HPC), chlorine consumption and hydraulic change. So bacterial growth (HPC) doesn’t have any relationship with THMs and Tol Coli form, but has a reversed relationship with residual chlorine nearly.
