An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally ...An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally weighted quadratic least=squares regression （called as LOESS） method from six-hour satellite surface wind data; the extracted TCW component can then be additionally taken into account or not in ocean modeling, allowing isolation of its effects on the ocean in a clean and clear way. In this paper, seasonally varying TCW fields in year 2008 are extracted from satellite data which are prescribed as a repeated annual cycle over the western Pacific regions off the equator （poleward of 10°N/S）; two long-term OGCM experiments are performed and compared, one with the TCW forcing part included additionally and the other not. Large, persistent thermal perturbations （cooling in the mixed layer （ML） and warming in the thermocline） are induced locally in the western tropical Pacific, which are seen to spread with the mean ocean circulation pathways around the tropical basin. In particular, a remote ocean response emerges in the eastern equatorial Pacific to the prescribed off-equatorial TCW forcing, characterized by a cooling in the mixed layer and a warming in the thermocline. Heat budget analyses indicate that the vertical mixing is a dominant process responsible for the SST cooling in the eastern equatorial Pacific. Further studies are clearly needed to demonstrate the significance of these results in a coupled ocean-atmosphere modeling context.展开更多
Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a ...Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a treatment for cerebral palsy and skeletal muscle hypertrophy.In China,Chinese botulinum toxin type A(CBTX-A),a type of BoNT/A,is in widespread clinical use.However,the changes in the morphological and biochemical properties of treated muscles and in remote muscles from the CBTX-A injection site are relatively unknown.Therefore,we investigated the changes in histomorphology and myosin heavy chain(MyHC)isoform composition and distribution in rat gastrocnemius muscles after intramuscular injection of CBTX-A.Methods:The weakness of the injected muscles was assessed periodically to identify their functional deficiency.Muscle slices were stained with hematoxylin-eosin(HE)and adenosine triphosphatase(ATPase).MyHC isoform composition was analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis(SDS-PAGE)to uncover changes in morphological and biochemical properties.Results:Our findings demonstrate that following injection of CBTX-A 5 U into rat gastrocnemius muscles,shifts in MyHC isoform composition emerged on the third day after injection and peaked in the fourth week.The composition remained distinctly different from that of the control group after the twelfth week.More specifically,there was a decrease in the proportion of the type IIb isoform and an increase in the proportions of type IIx,type IIa,and type I isoforms.Conclusions:Data revealed that CBTX-A led to a shift in MyHC composition towards slower isoforms and that the MyHC composition remained far from normal six months after a single injection.However,no noticeable remote muscle weakness was induced.展开更多
基金supported in part by NSF Grant(Grant No.AGS-1061998)NOAA Grant(Grant No.NA08OAR4310885)+3 种基金NASA Grants(Grant Nos.NNX08AT50G and NNX09AF41G)supportedby the National Basic Research Program of China(Grant No.2013CB430302)the Public Science and Technology Research Funds of Ocean(Grant No.201105018)additionally supported by China Scholarship Council(CSC)with The Ocean University of China,Qingdao,China
文摘An ocean general circulation model （OGCM） is used to demonstrate remote effects of tropical cyclone wind （TCW） forcing in the tropical Pacific. The signature of TCW forcing is explicitly extracted using a locally weighted quadratic least=squares regression （called as LOESS） method from six-hour satellite surface wind data; the extracted TCW component can then be additionally taken into account or not in ocean modeling, allowing isolation of its effects on the ocean in a clean and clear way. In this paper, seasonally varying TCW fields in year 2008 are extracted from satellite data which are prescribed as a repeated annual cycle over the western Pacific regions off the equator （poleward of 10°N/S）; two long-term OGCM experiments are performed and compared, one with the TCW forcing part included additionally and the other not. Large, persistent thermal perturbations （cooling in the mixed layer （ML） and warming in the thermocline） are induced locally in the western tropical Pacific, which are seen to spread with the mean ocean circulation pathways around the tropical basin. In particular, a remote ocean response emerges in the eastern equatorial Pacific to the prescribed off-equatorial TCW forcing, characterized by a cooling in the mixed layer and a warming in the thermocline. Heat budget analyses indicate that the vertical mixing is a dominant process responsible for the SST cooling in the eastern equatorial Pacific. Further studies are clearly needed to demonstrate the significance of these results in a coupled ocean-atmosphere modeling context.
基金Project (No.491030-w10011) supported by the Zhejiang Provincial Natural Science Foundation of China
文摘Background and objective:Botulinum toxin type A(BoNT/A)is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa(SNAP-25).It has gained widespread use as a treatment for cerebral palsy and skeletal muscle hypertrophy.In China,Chinese botulinum toxin type A(CBTX-A),a type of BoNT/A,is in widespread clinical use.However,the changes in the morphological and biochemical properties of treated muscles and in remote muscles from the CBTX-A injection site are relatively unknown.Therefore,we investigated the changes in histomorphology and myosin heavy chain(MyHC)isoform composition and distribution in rat gastrocnemius muscles after intramuscular injection of CBTX-A.Methods:The weakness of the injected muscles was assessed periodically to identify their functional deficiency.Muscle slices were stained with hematoxylin-eosin(HE)and adenosine triphosphatase(ATPase).MyHC isoform composition was analyzed by sodium dodecyl sulfatepolyacrylamide gel electrophoresis(SDS-PAGE)to uncover changes in morphological and biochemical properties.Results:Our findings demonstrate that following injection of CBTX-A 5 U into rat gastrocnemius muscles,shifts in MyHC isoform composition emerged on the third day after injection and peaked in the fourth week.The composition remained distinctly different from that of the control group after the twelfth week.More specifically,there was a decrease in the proportion of the type IIb isoform and an increase in the proportions of type IIx,type IIa,and type I isoforms.Conclusions:Data revealed that CBTX-A led to a shift in MyHC composition towards slower isoforms and that the MyHC composition remained far from normal six months after a single injection.However,no noticeable remote muscle weakness was induced.
