Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circul...Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation） in treating patients with cardiac syndrome X （CSX）. Methods： The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment （32 patients）, and the control group treated with conventional treatment （19 patients） like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results： After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group （P〈0.05）; the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group （P〈0.05）. The treadmill exercise test showed that the maximal metabolic equivalent （Max MET）, the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively （P〈0.05）. Conclusion： The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.展开更多
OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastere...OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.展开更多
The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs posses...The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.展开更多
The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the...The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the reduction of chlorophyll content, the accumulation of MDA(malondiadehyde) and the elevation of relative membrane penetrability (RMP). After adding 10 mg . L-1 La to the solution, the activities of SOD and CAT in the leaves of Hydrocharis dubia B L. Backer increases compared with those of the single treatment of Ni, while the activity of POD decreases. It reveals that la enhances the abilities of scavenging the activated oxygen in the plant and alleviates the damage to the membranes. The soluble protein content with Ni and La compound treatment is higher than that of single Ni does, and proline content is contrary to the soluble protein content. So La improves the resistance of Hydrocharis dubia B. L. Backer to the stress of Ni. However, La can aggravate the damage to the cells under the extremely high concentration of Ni treatment.展开更多
Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbos...Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes com展开更多
基金Priority Project of Tianjin Science Technical Commission (No. 05YFGDSF02200)Yan De-xin Foundation Project (No. 05-012)
文摘Objective： To evaluate the clinical effect of Liqi Kuanxiong Huoxue method （宽胸活血,LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation） in treating patients with cardiac syndrome X （CSX）. Methods： The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment （32 patients）, and the control group treated with conventional treatment （19 patients） like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results： After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group （P〈0.05）; the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group （P〈0.05）. The treadmill exercise test showed that the maximal metabolic equivalent （Max MET）, the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively （P〈0.05）. Conclusion： The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.
基金Supported by Special Project of National Clinical Research Base of TCM (No. JDZX2012140)Innovation Team Development Plan of the Ministry of Education (No. IRT1276)
文摘OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.
文摘The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.
文摘The paper briefly dealt with relieving toxic effects of La on high aquatic plant-Hydrocharis dubia B L. Backer growing in the solution containing different concentration of Ni. The results show that La can relieve the reduction of chlorophyll content, the accumulation of MDA(malondiadehyde) and the elevation of relative membrane penetrability (RMP). After adding 10 mg . L-1 La to the solution, the activities of SOD and CAT in the leaves of Hydrocharis dubia B L. Backer increases compared with those of the single treatment of Ni, while the activity of POD decreases. It reveals that la enhances the abilities of scavenging the activated oxygen in the plant and alleviates the damage to the membranes. The soluble protein content with Ni and La compound treatment is higher than that of single Ni does, and proline content is contrary to the soluble protein content. So La improves the resistance of Hydrocharis dubia B. L. Backer to the stress of Ni. However, La can aggravate the damage to the cells under the extremely high concentration of Ni treatment.
基金Supported by the National Natural Science Foundation of China (No.30801495)
文摘Objective： To investigate the anticancer effects of warming and relieving cold phlegm formula （温化寒痰复方, WRCP）, a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis G u enther, combined with 5-fluorouracil （5-FU） on human breast cancer in vivo. Methods： Seventy-two Nu/Nu mica inoculated with MDAMB-231 breast cancer cells were randomized into the control group, 5-FU group, high-dose WRCP （hWRCP） group, medium-dose WRCP （mWRCP） group, low-dose WRCP （IWRCP） group, or combination of mWRCP and 5-FU group in a 1：1：1：1：1：1 ratio. Drug administration was commenced on the day following tumor implantation. The control group was injected daily with normal saline （N.S.） intraperitoneally; the 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day for a total of 7 treatments; the hWRCP group, mWRCP group and IWRCP group received daily doses of 5, 1, and 0.2 g/kg of WRCP, respectively, by gastric perfusion; and the combination group was treated with 5-FU plus mWRCP on the same schedules as above. All treatments lasted for 22 days. Tumor volume, tumor weight, inhibition rate of tumor weight, necrosis rate of tumor, organ index, and change in body weight of nude mice were measured. Results： The combination group and the hWRCP group had significantly smaller tumor volumes （580 ±339 mm3 and 587 ± 249 mm3 versus 1055 ± 234 mm3, respectively）, lower tumor weights （0.42 ± 0.29 g and 0.52 ± 0.29 g versus 0.80 ± 0.15 g, respectively）, and higher tumor necrosis rates （22.7% and 25.6% versus 9.4%, respectively） as compared with the control group （all P〈0.05）. Similar changes were found in the 5-FU, mWRCP, and IWRCP groups when compared with the control group but were not statistically significant, except for the tumor weight for the 5-FU group. The combination group and the hWRCP group had significantly smaller tumor volumes com
