Objective To decompose and reformulate Banxia Baizhu Tianma Decoction（BBT） in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR ana...Objective To decompose and reformulate Banxia Baizhu Tianma Decoction（BBT） in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR analysis.Methods The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled water.The vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring model.Among these extracts,the water extracts of Pinellia ternata[PT（W）]and Citri reticulatae[CR（W）],50%ethanol extracts of Castrodia elata[GE（50）]and Clycyrrhiza uralensis[GU（50）],and 95%ethanol extracts of Atractylodes macrocephala[AM（E）],and Poria cocos[PC（E）]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in vasodilation.Results The best combination ratio（G2） was GE（50）,GU（50）,AM（E）,PC（E）,CR（W）,and PT（W） at EC0,EC5,EC5,EC5,EC5,and EC5,with EC50 of（0.06 ± 0.01） mg/mL.Comparison between the vasodilatory effects of extracts derived from G2 and BBT were also studied.From the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC50 of（0.05 ±0.005） mg/mL.Conclusion The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic rings.The results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect.展开更多
Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly w...Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. Stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.展开更多
There are some curved interfaces in ocean acoustic waveguides. To compute wave propagation along the range with some marching methods, a flattening of the internal interfaces and a transforming equation are needed. In...There are some curved interfaces in ocean acoustic waveguides. To compute wave propagation along the range with some marching methods, a flattening of the internal interfaces and a transforming equation are needed. In this paper a local orthogonal coordinate transform and an equation transformation are constructed to flatten interfaces and change the Helmholtz equation as a solvable form. For a waveguide with a flat top, a fiat bottom and n curved interfaces, the coefficients of the transformed Helmholtz equation are given in a closed formulation which can be thought of as an extension of the formal work related to the equation transformation with two curved internal interfaces. In the transformed horizontally stratified waveguide, the one-way reformulation based on the Dirichlet-to-Neumann （DtN） map is then used to reduce the boundary value problem to an initial value problem. Numerical implementation of the resulting operator Riccati equation uses a large range step method to discretize the range variable and a truncated local eigenfunction expansion to approximate the operators. This method is particularly useful for solving long range wave propagation problems in slowly varying waveguides. Furthermore, the method can also be applied to wave propagation problems in acoustic waveguides associated with varied density.展开更多
Mathematical programming problems with semi-continuous variables and cardinality constraint have many applications,including production planning,portfolio selection,compressed sensing and subset selection in regressio...Mathematical programming problems with semi-continuous variables and cardinality constraint have many applications,including production planning,portfolio selection,compressed sensing and subset selection in regression.This class of problems can be modeled as mixed-integer programs with special structures and are in general NP-hard.In the past few years,based on new reformulations,approximation and relaxation techniques,promising exact and approximate methods have been developed.We survey in this paper these recent developments for this challenging class of mathematical programming problems.展开更多
Flattening of the interfaces is necessary in computing wave propagation along strati?ed waveguides in large range step sizes while using marching methods. When the supposition that there exists one horizontal straight...Flattening of the interfaces is necessary in computing wave propagation along strati?ed waveguides in large range step sizes while using marching methods. When the supposition that there exists one horizontal straight line in two adjacent interfaces does not hold, the previously suggested local orthogonal transform method with an analytical formulation is not feasible. This paper presents a numerical coordinate transform and an equation transform to perform the transforms numerically for waveguides without satisfying the supposition. The boundary value problem is then reduced to an initial value problem by one-way reformulation based on the Dirichlet-to-Neumann (DtN) map. This method is applicable in solving long-range wave propagation problems in slowly varying waveguides with a multilayered medium structure.展开更多
We propose a reformulation of Newton’s second law of motion for charged particles and possible applications of the reformulation to quantum dynamics. We show that the negative energy states arising from the Dirac equ...We propose a reformulation of Newton’s second law of motion for charged particles and possible applications of the reformulation to quantum dynamics. We show that the negative energy states arising from the Dirac equation in relativistic quantum mechanics can be verified using the reformulating framework. We also discuss possible hidden dynamics underlying the concept of quantum jumps in quantum mechanics as outlined in Schr<span style="font-size:12px;white-space:nowrap;">ö</span>dinger’s article: ARE THERE QUANTUM JUMPS? In this case, we show that the hidden dynamics of quantum jumps are also determined by the Coulomb interaction between charged particles.展开更多
Formulation of SLCLSP given by Pochet and Wolsey [1] had set up, variables, inventory and shortage cost. We give a new reformulation where SLCLSP is reduced to set up and inventory variables. We find that this reformu...Formulation of SLCLSP given by Pochet and Wolsey [1] had set up, variables, inventory and shortage cost. We give a new reformulation where SLCLSP is reduced to set up and inventory variables. We find that this reformulation has less number of real variables than the reformulation of Pochet and Wolsey [1]. It is argued that this leads to computations advantages, and this is supported by the empirical investigation that we carried out.展开更多
This study examined users' querying behaviors based on a sample of 30 Chinese college students from Peking University. The authors designed 5 search tasks and each participant conducted two randomly selected searc...This study examined users' querying behaviors based on a sample of 30 Chinese college students from Peking University. The authors designed 5 search tasks and each participant conducted two randomly selected search tasks during the experiment. The results show that when searching for pre-designed search tasks, users often have relatively clear goals and strategies before searching. When formulating their queries, users often select words from tasks, use concrete concepts directly, or extract 'central words' or keywords. When reformulating queries, seven query reformulation types were identified from users' behaviors, i.e. broadening, narrowing, issuing new query, paralleling, changing search tools, reformulating syntax terms, and clicking on suggested queries. The results reveal that the search results and/or the contexts can also influence users' querying behaviors.展开更多
基金Exploratory Research Grant Scheme(ERGS)(203/PFARMASI/6730122)Universiti Sains Malaysia-Research University Grants(1001/PFARMASI/812195)
文摘Objective To decompose and reformulate Banxia Baizhu Tianma Decoction（BBT） in order to optimize its ratio for vasodilatory effect.The fingerprints of these six component herbs were also studied via Tri-step FTIR analysis.Methods The herbal components of BBT were extracted separately with different solvents,such as 95%ethanol,50%ethanol,and distilled water.The vasodilatory effect of the extracts was studied using the in vitro pre-contracted aortic ring model.Among these extracts,the water extracts of Pinellia ternata[PT（W）]and Citri reticulatae[CR（W）],50%ethanol extracts of Castrodia elata[GE（50）]and Clycyrrhiza uralensis[GU（50）],and 95%ethanol extracts of Atractylodes macrocephala[AM（E）],and Poria cocos[PC（E）]were selected for the orthogonal stimulus-response compatibility group study due to their high effectiveness in vasodilation.Results The best combination ratio（G2） was GE（50）,GU（50）,AM（E）,PC（E）,CR（W）,and PT（W） at EC0,EC5,EC5,EC5,EC5,and EC5,with EC50 of（0.06 ± 0.01） mg/mL.Comparison between the vasodilatory effects of extracts derived from G2 and BBT were also studied.From the results,the 50%ethanol extract following G2 ratio was found to be most potent extract with the highest vasodilatory effect compared with other extracts derived from G2 or BBT,with EC50 of（0.05 ±0.005） mg/mL.Conclusion The optimum ratio and appropriate extraction method for the new BBT formulae are obtained.G2 is determined as the best formulae with the highest potency in producing the vasodilatory effect on isolated rat aortic rings.The results obtained suggest that 50%ethanol is found to be the best solvent to extract the vasoactive compounds of G2 in order to exhibit the highest efficacy of vasodilatory effect.
文摘Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. Stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.
基金the National Natural Science Foundation of China (No. 10571162)the Natural Science Foundation of Zheji-ang Province, China (No. Y605181)
文摘There are some curved interfaces in ocean acoustic waveguides. To compute wave propagation along the range with some marching methods, a flattening of the internal interfaces and a transforming equation are needed. In this paper a local orthogonal coordinate transform and an equation transformation are constructed to flatten interfaces and change the Helmholtz equation as a solvable form. For a waveguide with a flat top, a fiat bottom and n curved interfaces, the coefficients of the transformed Helmholtz equation are given in a closed formulation which can be thought of as an extension of the formal work related to the equation transformation with two curved internal interfaces. In the transformed horizontally stratified waveguide, the one-way reformulation based on the Dirichlet-to-Neumann （DtN） map is then used to reduce the boundary value problem to an initial value problem. Numerical implementation of the resulting operator Riccati equation uses a large range step method to discretize the range variable and a truncated local eigenfunction expansion to approximate the operators. This method is particularly useful for solving long range wave propagation problems in slowly varying waveguides. Furthermore, the method can also be applied to wave propagation problems in acoustic waveguides associated with varied density.
基金supported by the National Natural Science Foundation of China grants(Nos.11101092,10971034)the Joint National Natural Science Foundation of China/Research Grants Council of Hong Kong grant(No.71061160506)the Research Grants Council of Hong Kong grants(Nos.CUHK414808 and CUHK414610).
文摘Mathematical programming problems with semi-continuous variables and cardinality constraint have many applications,including production planning,portfolio selection,compressed sensing and subset selection in regression.This class of problems can be modeled as mixed-integer programs with special structures and are in general NP-hard.In the past few years,based on new reformulations,approximation and relaxation techniques,promising exact and approximate methods have been developed.We survey in this paper these recent developments for this challenging class of mathematical programming problems.
基金Project supported by the Program for New Century Excel-lent Talents in University (No. NCET-08-0450)the 985 II of Xi’an Jiaotong University, and the High Talented Person Scientific Research Start Project of North China University of Water Resources and Electric Power (No. 003001)
文摘Flattening of the interfaces is necessary in computing wave propagation along strati?ed waveguides in large range step sizes while using marching methods. When the supposition that there exists one horizontal straight line in two adjacent interfaces does not hold, the previously suggested local orthogonal transform method with an analytical formulation is not feasible. This paper presents a numerical coordinate transform and an equation transform to perform the transforms numerically for waveguides without satisfying the supposition. The boundary value problem is then reduced to an initial value problem by one-way reformulation based on the Dirichlet-to-Neumann (DtN) map. This method is applicable in solving long-range wave propagation problems in slowly varying waveguides with a multilayered medium structure.
文摘We propose a reformulation of Newton’s second law of motion for charged particles and possible applications of the reformulation to quantum dynamics. We show that the negative energy states arising from the Dirac equation in relativistic quantum mechanics can be verified using the reformulating framework. We also discuss possible hidden dynamics underlying the concept of quantum jumps in quantum mechanics as outlined in Schr<span style="font-size:12px;white-space:nowrap;">ö</span>dinger’s article: ARE THERE QUANTUM JUMPS? In this case, we show that the hidden dynamics of quantum jumps are also determined by the Coulomb interaction between charged particles.
文摘Formulation of SLCLSP given by Pochet and Wolsey [1] had set up, variables, inventory and shortage cost. We give a new reformulation where SLCLSP is reduced to set up and inventory variables. We find that this reformulation has less number of real variables than the reformulation of Pochet and Wolsey [1]. It is argued that this leads to computations advantages, and this is supported by the empirical investigation that we carried out.
基金partially supported by China Scholarship Council(Grant No.:2009601175)
文摘This study examined users' querying behaviors based on a sample of 30 Chinese college students from Peking University. The authors designed 5 search tasks and each participant conducted two randomly selected search tasks during the experiment. The results show that when searching for pre-designed search tasks, users often have relatively clear goals and strategies before searching. When formulating their queries, users often select words from tasks, use concrete concepts directly, or extract 'central words' or keywords. When reformulating queries, seven query reformulation types were identified from users' behaviors, i.e. broadening, narrowing, issuing new query, paralleling, changing search tools, reformulating syntax terms, and clicking on suggested queries. The results reveal that the search results and/or the contexts can also influence users' querying behaviors.
