本文设计了一种适用于B/S结构的,复杂度和安全性适中的SSO协议,它在设计上吸取了很多Kerberos和CAS的设计思想,如Kerberos协议的票据与CAS协议中的重定向和Cookie管理技术。它的特点是使用加强的密码校验协议,不需传输密码或加密密码即...本文设计了一种适用于B/S结构的,复杂度和安全性适中的SSO协议,它在设计上吸取了很多Kerberos和CAS的设计思想,如Kerberos协议的票据与CAS协议中的重定向和Cookie管理技术。它的特点是使用加强的密码校验协议,不需传输密码或加密密码即可完成校验;采用简化的Kerberos票据管理技术;增加票据有效性的检验;由于鉴权服务器和应用服务器之间使用对称密码,所以在票据的加密时,使用主密钥分散技术,更安全的保护主密钥;改进Kerberos票据,增加application server sequence number,与时间戳共同解决重传攻击问题。展开更多
为了提供高质量的流媒体服务,内容发布网络(CDN)利用域名解析系统(DNS),将用户重定向到附近的内容服务器。近年来,域名解析系统的发展,尤其是基于IPAnycast的域名解析系统的兴起(例如,Google Public DNS,Open DNS),必将对CDN网络的内容...为了提供高质量的流媒体服务,内容发布网络(CDN)利用域名解析系统(DNS),将用户重定向到附近的内容服务器。近年来,域名解析系统的发展,尤其是基于IPAnycast的域名解析系统的兴起(例如,Google Public DNS,Open DNS),必将对CDN网络的内容发布机制造成影响。同Web、Email等其它Internet服务相比,流媒体服务对网络资源有较高的要求,DNS对其影响更加明显。本文首先阐明基于IPAnycast的域名解析系统对CDN网络内容发布模型的冲击,然后分析其影响流媒体服务质量的各种因素,最后通过实验来比较当使用不同域名解析服务时CDN网络承载的流媒体的服务质量。展开更多
T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T...T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.展开更多
文摘本文设计了一种适用于B/S结构的,复杂度和安全性适中的SSO协议,它在设计上吸取了很多Kerberos和CAS的设计思想,如Kerberos协议的票据与CAS协议中的重定向和Cookie管理技术。它的特点是使用加强的密码校验协议,不需传输密码或加密密码即可完成校验;采用简化的Kerberos票据管理技术;增加票据有效性的检验;由于鉴权服务器和应用服务器之间使用对称密码,所以在票据的加密时,使用主密钥分散技术,更安全的保护主密钥;改进Kerberos票据,增加application server sequence number,与时间戳共同解决重传攻击问题。
文摘为了提供高质量的流媒体服务,内容发布网络(CDN)利用域名解析系统(DNS),将用户重定向到附近的内容服务器。近年来,域名解析系统的发展,尤其是基于IPAnycast的域名解析系统的兴起(例如,Google Public DNS,Open DNS),必将对CDN网络的内容发布机制造成影响。同Web、Email等其它Internet服务相比,流媒体服务对网络资源有较高的要求,DNS对其影响更加明显。本文首先阐明基于IPAnycast的域名解析系统对CDN网络内容发布模型的冲击,然后分析其影响流媒体服务质量的各种因素,最后通过实验来比较当使用不同域名解析服务时CDN网络承载的流媒体的服务质量。
基金supported by the National Natural Science Foundation of China(Nos.32070940 and 81991491)the China Postdoctoral Science Foundation(No.2021M700115)+2 种基金the Postdoctoral Innovation Talents Support Program(No.BX20220189,China)the Science and Technology Planning Project of Fujian Province(No.2022L3080,China)the CAMS Innovation Fund for Medical Sciences(No.2019RU022,China).
文摘T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.
