Twenty-four male Kazak sheep and 30 Xinjiang fine wool sheep at different ages were selected to investigate the development-dependent expression levels of fatty acid synthase （FAS） gene and hormone-sensitive lipase ...Twenty-four male Kazak sheep and 30 Xinjiang fine wool sheep at different ages were selected to investigate the development-dependent expression levels of fatty acid synthase （FAS） gene and hormone-sensitive lipase （HSL） gene in muscle and their effects on the contents of intramuscular fat （IMF）. Longissimus dorsal muscle was sampled to measure IMF and total RNA was extracted to determine FAS and HSL mRNA expression levels by real-time PCR. The results showed that： l） The IMF content increased continuously with growth and showed significant differences （P 〈 0.05） between different age groups in male Kazak sheep, but in Xinjiang fine wool sheep there was no such difference observed. Furthermore, the IMF contents in Kazak were much higher （P 〈 0.01） than that of the other breed from day 30 to 90. 2） FAS mRNA expression level was the highest （P 〈 0.05） on day 0 in Kazak sheep and then declined with growth, in the other breed the gene showed a d‘ecline-rise-decline-rise＇ expression manner as the animals grew. HSL mRNA expression level had a similar model in two breeds, in Kazak sheep it was the highest on day 0 （P 〈 0.05） and in Xinjiang fine wool sheep on day 30 （P 〈 0.01）, then both decreased after this term. 3） In male Kazak sheep, FAS and HSL mRNA expression level were both negatively related to IMF content （r= -0.485 （P = 0.02）, r= -0.423 （P = 0.05））, and the ratio of FAS/HSL expression exhibited significantly negatively related IMF contents. In male Xinjiang sheep, there were no obvious relationship between FAS and HSL expression and IMF content （P 〉 0.05）.展开更多
Considering the fact that high arch dams have problems such as complicated stress,high cost,and hazards after being damaged,this paper intends to study the effects of load,material strength,and safety analysis method ...Considering the fact that high arch dams have problems such as complicated stress,high cost,and hazards after being damaged,this paper intends to study the effects of load,material strength,and safety analysis method on dam safety and working performance of arch dams.In this article,the effects of temperature,self weight exaction way and water loading on structure response are first discussed,and a more reasonable way of considering is then put forward.By taking into consideration the mechanical property of materials and comparing the effects of different yield criteria on overloading safety of high arch dams,this paper concludes that brittle characteristics of concrete should be fully considered when conducting safety assessment for high arch dams to avoid overestimating the bearing capacity of the dams.By comparing several typical projects,this paper works out a safety assessment system of multiple safety and relevant engineering analogical analysis methods,which is closer to the actual situation,and thus is able to assess the response of high arch dam structure in a more comprehensive way,elicit the safety coefficients in different situations,and provide a new way of considering the safety assessment of high arch dams.展开更多
AIM:To develop a novel 3-dimensional(3D) virtual hepatectomy simulation software,Liversim,to visualize the real-time deformation of the liver.METHODS:We developed a novel real-time virtual hepatectomy simulation softw...AIM:To develop a novel 3-dimensional(3D) virtual hepatectomy simulation software,Liversim,to visualize the real-time deformation of the liver.METHODS:We developed a novel real-time virtual hepatectomy simulation software program called Liversim. The software provides 4 basic functions:viewing 3D models from arbitrary directions,changing the colors and opacities of the models,deforming the models based on user interaction,and incising the liver parenchyma and intrahepatic vessels based on user operations. From April 2010 through 2013,99 patients underwent virtual hepatectomies that used the conventional software program SYNAPSE VINCENT preoperatively. Between April 2012 and October 2013,11 patients received virtual hepatectomies using the novel software program Liversim; these hepatectomies were performed both preoperatively and at the same that the actual hepatectomy was performed in an operating room. The perioperative outcomes were analyzed between the patients for whom SYNAPSE VINCENT was used and those for whom Liversim wasused. Furthermore,medical students and surgical residents were asked to complete questionnaires regarding the new software.RESULTS:There were no obvious discrepancies(i.e.,the emergence of branches in the portal vein or hepatic vein or the depth and direction of the resection line) between our simulation and the actual surgery during the resection process. The median operating time was 304 min(range,110 to 846) in the VINCENT group and 397 min(range,232 to 497) in the Liversim group(P = 0.30). The median amount of intraoperative bleeding was 510 m L(range,18 to 5120) in the VINCENT group and 470 m L(range,130 to 1600) in the Liversim group(P = 0.44). The median postoperative stay was 12 d(range,6 to 100) in the VINCENT group and 13 d(range,9 to 21) in the Liversim group(P = 0.36). There were no significant differences in the preoperative outcomes between the two groups. Liversim was not found to be clinically inferior to SYNAPSE VINCENT. Both students and surgical residents reported that th展开更多
Transitional cell carcinoma （TCC） of bladder is the most common malignant tumor in uropoiesis system. Up to date, there is still lack of an ideal marker for the diagnosis of TCC except CT and MRI imaging and cystosc...Transitional cell carcinoma （TCC） of bladder is the most common malignant tumor in uropoiesis system. Up to date, there is still lack of an ideal marker for the diagnosis of TCC except CT and MRI imaging and cystoscopy. Cystoscopy is an invasive examination, which increases the possibility of urinary tract infection. Urine cytology has low sensitivity （21%--40%） in diagnosis of bladder cancer, especially for those with medium or high differentiation. The specificity is often affected by factors such as specimen collection, urinary tract infection, etc. Detecting the expression of survivin mRNA in urine by real time-PCR is simple in specimen collection and is sensitive and relatively specific, which provides a simple and noninvasive diagnostic method for TCC. Moreover it allows comparing the gene expression levels at different stages and grades of TCC, which can help define malignancy degree of TCC.展开更多
Content-aware image resizing is a kind of new and effective approach for image resizing, which preserves image content well and does not cause obvious distortion when changing the aspect ratio of images. Recently, a s...Content-aware image resizing is a kind of new and effective approach for image resizing, which preserves image content well and does not cause obvious distortion when changing the aspect ratio of images. Recently, a seam based approach for content-aware image resizing was proposed by Avidan and Shamir. Their results are impressive, but because the method uses dynamic programming many times, it is slow. In this paper, we present a more efficient algorithm for seam based content-aware iraage resizing, which searches seams through establishing the matching relation between adjacent rows or columns. We give a linear algorithm to find the optimal matches within a weighted bipartite graph composed of the pixels in adjacent rows or columns. Therefore, our method is fast （e.g. our method needs only about 100 ms to reduce a 768x1024 Image＇s width to 1/3 while Avidan and Shamir＇s method needs 12 s）. This supports immediate image resizing whereas Avidan and Shamir＇s method requires a more costly pre-processing step to enable subsequent real-time processing. A fast method such as the one proposed will be also needed for future real-time video resizing applications.展开更多
流媒体 (stream ing m edia)是一种新兴的网络传输技术 ,在互联网上实时顺序地传输和播放视 /音频等多媒体内容的连续时基数据流 ,流媒体技术包括流媒体数据采集、视 /音频编解码、存储、传输、播放等领域。本文分别从流媒体的技术原理...流媒体 (stream ing m edia)是一种新兴的网络传输技术 ,在互联网上实时顺序地传输和播放视 /音频等多媒体内容的连续时基数据流 ,流媒体技术包括流媒体数据采集、视 /音频编解码、存储、传输、播放等领域。本文分别从流媒体的技术原理、传输方式、传输协议等方面对流媒体做出阐述。展开更多
We study the interpolation of Morrey-Campanato spaces and some smoothness spaces based on Morrey spaces, e. g., Besov-type and Triebel-Lizorkin-type spaces. Various interpolation methods, including the complex method,...We study the interpolation of Morrey-Campanato spaces and some smoothness spaces based on Morrey spaces, e. g., Besov-type and Triebel-Lizorkin-type spaces. Various interpolation methods, including the complex method, the ±-method and the Peetre-Gagliardo method, are studied in such a framework. Special emphasis is given to the quasi-Banach case and to the interpolation property.展开更多
为了探明刺五加鲨烯合酶(SS)基因家族2成员对皂苷含量的作用机制,以actin为内参基因,利用real time PCR技术,分析刺五加不同生长发育时期、不同器官及茉莉酸甲酯(MeJA)处理对SS1、SS2基因表达及皂苷含量的影响。结果表明:刺五加SS基因...为了探明刺五加鲨烯合酶(SS)基因家族2成员对皂苷含量的作用机制,以actin为内参基因,利用real time PCR技术,分析刺五加不同生长发育时期、不同器官及茉莉酸甲酯(MeJA)处理对SS1、SS2基因表达及皂苷含量的影响。结果表明:刺五加SS基因家族的SS1和SS2在整个生长期和各器官中均有表达,且表达量差异显著(P<0.05),其中,在萌芽期两者的表达量差异最大。SS1在叶片、叶柄和根器官中的表达量显著高于SS2的表达量(P<0.05)。MeJA处理可显著提高SS1和SS2基因的表达量。刺五加SS1的表达量与皂苷含量间的相关系数低,未达显著水平。SS2的表达量与皂苷含量呈显著的正相关关系(P<0.01)。SS2表达量的高低决定了皂苷含量的高低,是刺五加中三萜皂苷生物合成中的关键酶。展开更多
This paper presents a computationally efficient real-time trajectory planning framework for typical unmanned combat aerial vehicle （UCAV） performing autonomous air-to-surface （A/S） attack. It combines the benefits...This paper presents a computationally efficient real-time trajectory planning framework for typical unmanned combat aerial vehicle （UCAV） performing autonomous air-to-surface （A/S） attack. It combines the benefits of inverse dynamics optimization method and receding horizon optimal control technique. Firstly, the ground attack trajectory planning problem is mathematically formulated as a receding horizon optimal control problem （RHC-OCP）. In particular, an approximate elliptic launch acceptable region （LAR） model is proposed to model the critical weapon delivery constraints. Secondly, a planning algorithm based on inverse dynamics optimization, which has high computational efficiency and good convergence properties, is developed to solve the RHCOCP in real-time. Thirdly, in order to improve robustness and adaptivity in a dynamic and uncer- tain environment, a two-degree-of-freedom （2-DOF） receding horizon control architecture is introduced and a regular real-time update strategy is proposed as well, and the real-time feedback can be achieved and the not-converged situations can be handled. Finally, numerical simulations demon- strate the efficiency of this framework, and the results also show that the presented technique is well suited for real-time implementation in dynamic and uncertain environment.展开更多
Manufacturing and services constitute two of the five sectors of every country＇s economy;depending on the maturity of the economy,they are-in terms of employment-typically the two largest sectors.The outputs or produ...Manufacturing and services constitute two of the five sectors of every country＇s economy;depending on the maturity of the economy,they are-in terms of employment-typically the two largest sectors.The outputs or products of an economy can also be divided into goods products（due to manufacturing,construction,agriculture and mining） and services products.To date,the goods and services products have,for the most part,been mass produced;it is the premise of this paper that recent technological advances-including flexible manufacturing,cloud computing,nanotechnology and smart sensing-can better enable the transformation from mass production to mass customization.We regard mass customization as the simultaneous and real time management of supply and demand chains,based on a taxonomy that can be defined in terms of its underpinning component and management foci.From a components perspective,we first consider the value chain of supplier,manufacturer,assembler,retailer,and customer,and then develop a consistent set of definitions for supply and demand chains based on the location of the customer order penetration point.From a management perspective,we classify the methods that are employed in the management of these chains,based on whether supply and/or demand are flexible or fixed.Interestingly,our management taxonomy highlights a very critical research area at which both supply and demand are flexible,thus manageable.Simultaneous management of supply and demand chains sets the stage for mass customization which is concerned with meeting the needs of an individualized customer market.Simultaneous and real time management of supply and demand chains set the stage for real time mass customization（e.g.,wherein a tailor first laser scans an individual＇s upper torso and then delivers a uniquely fitted jacket within a reasonable period,while the individual is waiting）.The benefits of real time mass customization cannot be over-stated as goods and services become indistinguishable and are co-produced-as ＂servgoods�展开更多
In the context of this work,a prototype hybrid photoacoustic(PA)and optical system for the on-line monitoring of laser cleaning procedures is presented.The developed apparatus has enabled the detection of MHz frequenc...In the context of this work,a prototype hybrid photoacoustic(PA)and optical system for the on-line monitoring of laser cleaning procedures is presented.The developed apparatus has enabled the detection of MHz frequency range acoustic waves generated during the laser ablation process.The intrinsically generated PA signals combined with high resolution optical images provide the opportunity to follow the cleaning process accurately and in real time.Technical mock-ups have been used to demonstrate the potential of this novel technique with emphasis given to applications that refer to the restoration of Cultural Heritage(CH)surfaces.Towards this purpose,the real time monitoring of the laser assisted removal of unwanted encrustation from stonework has been achieved using IR and UV wavelengths.This novel approach has allowed for the precise determination of the critical number of laser pulses required for the elimination of the encrustation layer,while highlighting the dominant ablation mechanisms according to the irradiation wavelength.The promising results obtained using the prototype hybrid PA and optical system can open up new perspectives in the monitoring of laser cleaning interventions,promoting an improved restoration outcome.展开更多
基金National Natural Sciences Foundation of China (No. 30671503)Youth Science and Technology Innovation Foundation (No. KJ05011)SRT Program (No. 0605A09) of Nanjing Agriculture University.
文摘Twenty-four male Kazak sheep and 30 Xinjiang fine wool sheep at different ages were selected to investigate the development-dependent expression levels of fatty acid synthase （FAS） gene and hormone-sensitive lipase （HSL） gene in muscle and their effects on the contents of intramuscular fat （IMF）. Longissimus dorsal muscle was sampled to measure IMF and total RNA was extracted to determine FAS and HSL mRNA expression levels by real-time PCR. The results showed that： l） The IMF content increased continuously with growth and showed significant differences （P 〈 0.05） between different age groups in male Kazak sheep, but in Xinjiang fine wool sheep there was no such difference observed. Furthermore, the IMF contents in Kazak were much higher （P 〈 0.01） than that of the other breed from day 30 to 90. 2） FAS mRNA expression level was the highest （P 〈 0.05） on day 0 in Kazak sheep and then declined with growth, in the other breed the gene showed a d‘ecline-rise-decline-rise＇ expression manner as the animals grew. HSL mRNA expression level had a similar model in two breeds, in Kazak sheep it was the highest on day 0 （P 〈 0.05） and in Xinjiang fine wool sheep on day 30 （P 〈 0.01）, then both decreased after this term. 3） In male Kazak sheep, FAS and HSL mRNA expression level were both negatively related to IMF content （r= -0.485 （P = 0.02）, r= -0.423 （P = 0.05））, and the ratio of FAS/HSL expression exhibited significantly negatively related IMF contents. In male Xinjiang sheep, there were no obvious relationship between FAS and HSL expression and IMF content （P 〉 0.05）.
基金Supported by the National Natural Science Foundation of China (Grant Nos.50539010,50539020 and 50539120)
文摘Considering the fact that high arch dams have problems such as complicated stress,high cost,and hazards after being damaged,this paper intends to study the effects of load,material strength,and safety analysis method on dam safety and working performance of arch dams.In this article,the effects of temperature,self weight exaction way and water loading on structure response are first discussed,and a more reasonable way of considering is then put forward.By taking into consideration the mechanical property of materials and comparing the effects of different yield criteria on overloading safety of high arch dams,this paper concludes that brittle characteristics of concrete should be fully considered when conducting safety assessment for high arch dams to avoid overestimating the bearing capacity of the dams.By comparing several typical projects,this paper works out a safety assessment system of multiple safety and relevant engineering analogical analysis methods,which is closer to the actual situation,and thus is able to assess the response of high arch dam structure in a more comprehensive way,elicit the safety coefficients in different situations,and provide a new way of considering the safety assessment of high arch dams.
文摘AIM:To develop a novel 3-dimensional(3D) virtual hepatectomy simulation software,Liversim,to visualize the real-time deformation of the liver.METHODS:We developed a novel real-time virtual hepatectomy simulation software program called Liversim. The software provides 4 basic functions:viewing 3D models from arbitrary directions,changing the colors and opacities of the models,deforming the models based on user interaction,and incising the liver parenchyma and intrahepatic vessels based on user operations. From April 2010 through 2013,99 patients underwent virtual hepatectomies that used the conventional software program SYNAPSE VINCENT preoperatively. Between April 2012 and October 2013,11 patients received virtual hepatectomies using the novel software program Liversim; these hepatectomies were performed both preoperatively and at the same that the actual hepatectomy was performed in an operating room. The perioperative outcomes were analyzed between the patients for whom SYNAPSE VINCENT was used and those for whom Liversim wasused. Furthermore,medical students and surgical residents were asked to complete questionnaires regarding the new software.RESULTS:There were no obvious discrepancies(i.e.,the emergence of branches in the portal vein or hepatic vein or the depth and direction of the resection line) between our simulation and the actual surgery during the resection process. The median operating time was 304 min(range,110 to 846) in the VINCENT group and 397 min(range,232 to 497) in the Liversim group(P = 0.30). The median amount of intraoperative bleeding was 510 m L(range,18 to 5120) in the VINCENT group and 470 m L(range,130 to 1600) in the Liversim group(P = 0.44). The median postoperative stay was 12 d(range,6 to 100) in the VINCENT group and 13 d(range,9 to 21) in the Liversim group(P = 0.36). There were no significant differences in the preoperative outcomes between the two groups. Liversim was not found to be clinically inferior to SYNAPSE VINCENT. Both students and surgical residents reported that th
基金This work was supported by grants from the Talent Man Foundation of Jiangsu Province (No.RC2003094) as well as the Science Foundation of Jiangsu Province (No.H200517).
文摘Transitional cell carcinoma （TCC） of bladder is the most common malignant tumor in uropoiesis system. Up to date, there is still lack of an ideal marker for the diagnosis of TCC except CT and MRI imaging and cystoscopy. Cystoscopy is an invasive examination, which increases the possibility of urinary tract infection. Urine cytology has low sensitivity （21%--40%） in diagnosis of bladder cancer, especially for those with medium or high differentiation. The specificity is often affected by factors such as specimen collection, urinary tract infection, etc. Detecting the expression of survivin mRNA in urine by real time-PCR is simple in specimen collection and is sensitive and relatively specific, which provides a simple and noninvasive diagnostic method for TCC. Moreover it allows comparing the gene expression levels at different stages and grades of TCC, which can help define malignancy degree of TCC.
基金Supported by National Natural Science Foundation of China (Grant Nos.60575002 and 60641002)
文摘Content-aware image resizing is a kind of new and effective approach for image resizing, which preserves image content well and does not cause obvious distortion when changing the aspect ratio of images. Recently, a seam based approach for content-aware image resizing was proposed by Avidan and Shamir. Their results are impressive, but because the method uses dynamic programming many times, it is slow. In this paper, we present a more efficient algorithm for seam based content-aware iraage resizing, which searches seams through establishing the matching relation between adjacent rows or columns. We give a linear algorithm to find the optimal matches within a weighted bipartite graph composed of the pixels in adjacent rows or columns. Therefore, our method is fast （e.g. our method needs only about 100 ms to reduce a 768x1024 Image＇s width to 1/3 while Avidan and Shamir＇s method needs 12 s）. This supports immediate image resizing whereas Avidan and Shamir＇s method requires a more costly pre-processing step to enable subsequent real-time processing. A fast method such as the one proposed will be also needed for future real-time video resizing applications.
基金supported by National Natural Science Foundation of China(Grant Nos.11471042,11171027 and 11361020)the Alexander von Humboldt Foundation+1 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120003110003)the Fundamental Research Funds for Central Universities of China(Grant Nos.2013YB60 and 2014KJJCA10)
文摘We study the interpolation of Morrey-Campanato spaces and some smoothness spaces based on Morrey spaces, e. g., Besov-type and Triebel-Lizorkin-type spaces. Various interpolation methods, including the complex method, the ±-method and the Peetre-Gagliardo method, are studied in such a framework. Special emphasis is given to the quasi-Banach case and to the interpolation property.
文摘为了探明刺五加鲨烯合酶(SS)基因家族2成员对皂苷含量的作用机制,以actin为内参基因,利用real time PCR技术,分析刺五加不同生长发育时期、不同器官及茉莉酸甲酯(MeJA)处理对SS1、SS2基因表达及皂苷含量的影响。结果表明:刺五加SS基因家族的SS1和SS2在整个生长期和各器官中均有表达,且表达量差异显著(P<0.05),其中,在萌芽期两者的表达量差异最大。SS1在叶片、叶柄和根器官中的表达量显著高于SS2的表达量(P<0.05)。MeJA处理可显著提高SS1和SS2基因的表达量。刺五加SS1的表达量与皂苷含量间的相关系数低,未达显著水平。SS2的表达量与皂苷含量呈显著的正相关关系(P<0.01)。SS2表达量的高低决定了皂苷含量的高低,是刺五加中三萜皂苷生物合成中的关键酶。
基金supported by the National Defense Foundation of China(No.403060103)
文摘This paper presents a computationally efficient real-time trajectory planning framework for typical unmanned combat aerial vehicle （UCAV） performing autonomous air-to-surface （A/S） attack. It combines the benefits of inverse dynamics optimization method and receding horizon optimal control technique. Firstly, the ground attack trajectory planning problem is mathematically formulated as a receding horizon optimal control problem （RHC-OCP）. In particular, an approximate elliptic launch acceptable region （LAR） model is proposed to model the critical weapon delivery constraints. Secondly, a planning algorithm based on inverse dynamics optimization, which has high computational efficiency and good convergence properties, is developed to solve the RHCOCP in real-time. Thirdly, in order to improve robustness and adaptivity in a dynamic and uncer- tain environment, a two-degree-of-freedom （2-DOF） receding horizon control architecture is introduced and a regular real-time update strategy is proposed as well, and the real-time feedback can be achieved and the not-converged situations can be handled. Finally, numerical simulations demon- strate the efficiency of this framework, and the results also show that the presented technique is well suited for real-time implementation in dynamic and uncertain environment.
文摘Manufacturing and services constitute two of the five sectors of every country＇s economy;depending on the maturity of the economy,they are-in terms of employment-typically the two largest sectors.The outputs or products of an economy can also be divided into goods products（due to manufacturing,construction,agriculture and mining） and services products.To date,the goods and services products have,for the most part,been mass produced;it is the premise of this paper that recent technological advances-including flexible manufacturing,cloud computing,nanotechnology and smart sensing-can better enable the transformation from mass production to mass customization.We regard mass customization as the simultaneous and real time management of supply and demand chains,based on a taxonomy that can be defined in terms of its underpinning component and management foci.From a components perspective,we first consider the value chain of supplier,manufacturer,assembler,retailer,and customer,and then develop a consistent set of definitions for supply and demand chains based on the location of the customer order penetration point.From a management perspective,we classify the methods that are employed in the management of these chains,based on whether supply and/or demand are flexible or fixed.Interestingly,our management taxonomy highlights a very critical research area at which both supply and demand are flexible,thus manageable.Simultaneous management of supply and demand chains sets the stage for mass customization which is concerned with meeting the needs of an individualized customer market.Simultaneous and real time management of supply and demand chains set the stage for real time mass customization（e.g.,wherein a tailor first laser scans an individual＇s upper torso and then delivers a uniquely fitted jacket within a reasonable period,while the individual is waiting）.The benefits of real time mass customization cannot be over-stated as goods and services become indistinguishable and are co-produced-as ＂servgoods�
文摘In the context of this work,a prototype hybrid photoacoustic(PA)and optical system for the on-line monitoring of laser cleaning procedures is presented.The developed apparatus has enabled the detection of MHz frequency range acoustic waves generated during the laser ablation process.The intrinsically generated PA signals combined with high resolution optical images provide the opportunity to follow the cleaning process accurately and in real time.Technical mock-ups have been used to demonstrate the potential of this novel technique with emphasis given to applications that refer to the restoration of Cultural Heritage(CH)surfaces.Towards this purpose,the real time monitoring of the laser assisted removal of unwanted encrustation from stonework has been achieved using IR and UV wavelengths.This novel approach has allowed for the precise determination of the critical number of laser pulses required for the elimination of the encrustation layer,while highlighting the dominant ablation mechanisms according to the irradiation wavelength.The promising results obtained using the prototype hybrid PA and optical system can open up new perspectives in the monitoring of laser cleaning interventions,promoting an improved restoration outcome.
