Background The aim of this study was to prospectively study the changes in neutrophil elastase （NE）, fibroblast growth factor 9 （Fgf9）, matrix metalloproteinase-9 （MMP-9）, tissue inhibitor of metalloproteinase 1...Background The aim of this study was to prospectively study the changes in neutrophil elastase （NE）, fibroblast growth factor 9 （Fgf9）, matrix metalloproteinase-9 （MMP-9）, tissue inhibitor of metalloproteinase 1 （TIMP-1） in sputum induced during the early period after lung volume reduction surgery （LVRS）. Methods From April to October 2005, ten consecutive patients with chronic obstructive pulmonary disease （COPD） underwent LVRS. Ten non-small cell lung cancer patients （stage II-Illa） received Iobectomy as a control group. The induced sputum was collected from both groups at six different times （two weeks before operation and postoperatively at 1, 2, 4, 6 and 10 days）. The level of NE, Fgf9, MMP-9 and TIMP-1 were measured using enzyme-linked immunosorbent assay. Results The pulmonary function （FEV~%） and arterial blood gases （PaO2 and PaCO2） were significantly different belween the groups. There were no significant differences in age, ejection fraction （EF）, and operation duration, but hemoglobin in the LVRS group was statistically higher than in the controls. At certain times, there were significant differences in NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 （P 〈0.05） but not in Fgf9 between the two groups. The levels of NE and TIMP-1 were maximal at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 4 days postoperatively in the LVRS group. In the control group, maximal levels of NE and TIMP-1 occurred at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 1 day postoperatively. Ten days after surgery, all values of the control group were not significantly different from the baseline. In the LVRS group, the levels were significantly different from the pre-operative values （P 〈0.05） apart from TIMP-1. Conclusion The levels of NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 of the LVRS group were different from those of the control group. The time course of these chanties may be related to LVRS and the underlying process of COPD.展开更多
目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯...目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯特咳嗽问卷(Mandarin Chinese version of the Leicester cough questionnaire, LCQ-MC)评分、中医证候积分及各项炎性指标[血清白细胞介素-8(interleukin-8, IL-8)、肿瘤坏死因子-α(tumor necrosis factor, TNF-α)]的变化情况,并比较两组的临床疗效。结果 两组治疗后LCQ-MC评分较治疗前显著增加(P<0.01),中医证候积分较治疗前显著降低(P<0.01),且治疗组优于对照组(P<0.01)。两组治疗后血清IL-8和TNF-α水平均较治疗前显著降低(P<0.01),且治疗组低于对照组(P<0.01,P<0.05)。治疗组和对照组总有效率分别为86.7%和63.3%,两组比较差异有统计学意义(P<0.05)。结论 针药并用可有效改善肺部手术后慢性咳嗽的临床症状,提高临床疗效。展开更多
文摘Background The aim of this study was to prospectively study the changes in neutrophil elastase （NE）, fibroblast growth factor 9 （Fgf9）, matrix metalloproteinase-9 （MMP-9）, tissue inhibitor of metalloproteinase 1 （TIMP-1） in sputum induced during the early period after lung volume reduction surgery （LVRS）. Methods From April to October 2005, ten consecutive patients with chronic obstructive pulmonary disease （COPD） underwent LVRS. Ten non-small cell lung cancer patients （stage II-Illa） received Iobectomy as a control group. The induced sputum was collected from both groups at six different times （two weeks before operation and postoperatively at 1, 2, 4, 6 and 10 days）. The level of NE, Fgf9, MMP-9 and TIMP-1 were measured using enzyme-linked immunosorbent assay. Results The pulmonary function （FEV~%） and arterial blood gases （PaO2 and PaCO2） were significantly different belween the groups. There were no significant differences in age, ejection fraction （EF）, and operation duration, but hemoglobin in the LVRS group was statistically higher than in the controls. At certain times, there were significant differences in NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 （P 〈0.05） but not in Fgf9 between the two groups. The levels of NE and TIMP-1 were maximal at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 4 days postoperatively in the LVRS group. In the control group, maximal levels of NE and TIMP-1 occurred at 2 days postoperatively and that of MMP-9 and MMP-9/TIMP-1 at 1 day postoperatively. Ten days after surgery, all values of the control group were not significantly different from the baseline. In the LVRS group, the levels were significantly different from the pre-operative values （P 〈0.05） apart from TIMP-1. Conclusion The levels of NE, MMP-9, TIMP-1 and MMP-9/TIMP-1 of the LVRS group were different from those of the control group. The time course of these chanties may be related to LVRS and the underlying process of COPD.
文摘目的 观察针药并用治疗肺部手术后慢性咳嗽的临床疗效。方法 将60例肺部手术后慢性咳嗽患者随机分为治疗组和对照组,每组30例。对照组口服复方甲氧那明胶囊治疗,治疗组在对照组基础上采用针刺肺经腧穴治疗。比较两组治疗前后中文版莱斯特咳嗽问卷(Mandarin Chinese version of the Leicester cough questionnaire, LCQ-MC)评分、中医证候积分及各项炎性指标[血清白细胞介素-8(interleukin-8, IL-8)、肿瘤坏死因子-α(tumor necrosis factor, TNF-α)]的变化情况,并比较两组的临床疗效。结果 两组治疗后LCQ-MC评分较治疗前显著增加(P<0.01),中医证候积分较治疗前显著降低(P<0.01),且治疗组优于对照组(P<0.01)。两组治疗后血清IL-8和TNF-α水平均较治疗前显著降低(P<0.01),且治疗组低于对照组(P<0.01,P<0.05)。治疗组和对照组总有效率分别为86.7%和63.3%,两组比较差异有统计学意义(P<0.05)。结论 针药并用可有效改善肺部手术后慢性咳嗽的临床症状,提高临床疗效。
