目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行...目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行预处理。以双侧初级躯体感觉皮层(S1leg:初级躯体感觉皮层足代表区)作为种子点,进行功能连接分析并采用两样本t检验与健康对照组进行组间比较。将功能连接系数有显著性差异的脑区分别选为感兴趣区,以峰值坐标为中心提取球形区域内功能连接系数的平均值,与临床评估(视觉模拟量表评分、日本骨科协会评分、两点触觉辨别测试等)参数进行偏相关分析。结果与对照组相比,左侧S1leg和左侧前扣带回功能连接减弱(体素水平P<0.01,簇水平<0.05,GRF校正),而右侧S1leg和双侧小脑后叶功能连接增强(体素水平P<0.01,簇水平<0.05,GRF校正)。在LBLP患者组,右侧S1leg和双侧小脑后叶的功能连接系数与Barthel指数呈正相关(r=0.422,P=0.040)、与左手两点触觉辨别测试评分呈负相关(r=-0.447,P=0.028)、与右足两点触觉辨别测试评分呈负相关(r=-0.510,P=0.011)。结论静息状态下慢性LBLP患者存在和临床症状相关的初级躯体感觉皮层功能连接异常。展开更多
While the activation of primary somatosensory(SI) cortex during pain perception is consistently reported in functional imaging studies on normal subjects and chronic pain patients,the specific roles of SI,particularly...While the activation of primary somatosensory(SI) cortex during pain perception is consistently reported in functional imaging studies on normal subjects and chronic pain patients,the specific roles of SI,particularly the subregions within SI,in the processing of sensory aspects of pain are still largely unknown.Using optical imaging of intrinsic signal(OIS) and single unit electrophysiology,we studied cortical activation patterns within SI cortex(among Brodmann areas 3a,3b and 1) and signal amplitude changes to various intensities of non-nociceptive,thermal nociceptive and mechanical nociceptive stimulation of individual distal finerpads in anesthetized squirrel monkeys.We have demonstrated that areas 3a and 1 are preferentially involved in the processing of nociceptive information while areas 3b and 1 are preferentially activated in the processing of non-nociceptive(touch) information.Nociceptive activations of individual fingerpad were organized topographically suggesting that nociceptive topographic map exits in areas 3a and 1.Signal amplitude was enhanced to increasing intensity of mechanical nociceptive stimuli in areas 3a,3b and 1.Within area 1,nociceptive response co-localizes with the non-nociceptive response.Therefore,we hypothesize that nocicepitve information is area-specifically represented within SI cortex,in which nociceptive inputs are preferentially represented in areas 3a and 1 while non-nociceptive inputs are preferentially represented in areas 3b and 1.展开更多
文摘目的探讨慢性下腰腿痛(LBLP)患者静息态初级躯体感觉皮层的功能连接情况。方法采用3.0 T MRI对26例椎间盘突出所致LBLP患者(LBLP组)和34例健康志愿者(对照组)进行静息态fMRI扫描,使用脑成像数据处理及分析助手V3.0对静息态fMRI数据进行预处理。以双侧初级躯体感觉皮层(S1leg:初级躯体感觉皮层足代表区)作为种子点,进行功能连接分析并采用两样本t检验与健康对照组进行组间比较。将功能连接系数有显著性差异的脑区分别选为感兴趣区,以峰值坐标为中心提取球形区域内功能连接系数的平均值,与临床评估(视觉模拟量表评分、日本骨科协会评分、两点触觉辨别测试等)参数进行偏相关分析。结果与对照组相比,左侧S1leg和左侧前扣带回功能连接减弱(体素水平P<0.01,簇水平<0.05,GRF校正),而右侧S1leg和双侧小脑后叶功能连接增强(体素水平P<0.01,簇水平<0.05,GRF校正)。在LBLP患者组,右侧S1leg和双侧小脑后叶的功能连接系数与Barthel指数呈正相关(r=0.422,P=0.040)、与左手两点触觉辨别测试评分呈负相关(r=-0.447,P=0.028)、与右足两点触觉辨别测试评分呈负相关(r=-0.510,P=0.011)。结论静息状态下慢性LBLP患者存在和临床症状相关的初级躯体感觉皮层功能连接异常。
文摘While the activation of primary somatosensory(SI) cortex during pain perception is consistently reported in functional imaging studies on normal subjects and chronic pain patients,the specific roles of SI,particularly the subregions within SI,in the processing of sensory aspects of pain are still largely unknown.Using optical imaging of intrinsic signal(OIS) and single unit electrophysiology,we studied cortical activation patterns within SI cortex(among Brodmann areas 3a,3b and 1) and signal amplitude changes to various intensities of non-nociceptive,thermal nociceptive and mechanical nociceptive stimulation of individual distal finerpads in anesthetized squirrel monkeys.We have demonstrated that areas 3a and 1 are preferentially involved in the processing of nociceptive information while areas 3b and 1 are preferentially activated in the processing of non-nociceptive(touch) information.Nociceptive activations of individual fingerpad were organized topographically suggesting that nociceptive topographic map exits in areas 3a and 1.Signal amplitude was enhanced to increasing intensity of mechanical nociceptive stimuli in areas 3a,3b and 1.Within area 1,nociceptive response co-localizes with the non-nociceptive response.Therefore,we hypothesize that nocicepitve information is area-specifically represented within SI cortex,in which nociceptive inputs are preferentially represented in areas 3a and 1 while non-nociceptive inputs are preferentially represented in areas 3b and 1.
