Liuwei Dihuang decoction（LW），a classical traditional Chinese medicinal prescription with the effect of “nourishing Kidney-Yin”，consists of six herbs including Rehmannia glutinosa (Shudi),Cornus officinalis(Shauz...Liuwei Dihuang decoction（LW），a classical traditional Chinese medicinal prescription with the effect of “nourishing Kidney-Yin”，consists of six herbs including Rehmannia glutinosa (Shudi),Cornus officinalis(Shauzhuyu)，Dioscorea opposita(Shanyao)，Alisma orientale(Zexie)，Porie cocos （Fuling）and Paeonia suffruticosa （Mudanpi）．It has long been used clinically in the treatments of many kinds of diseases with the sign of “Kidney-Yin deficiency”，such as cancer ，diabetes，autoimmue diseases， menopausal syndrome in traditional Chinese medical treatments．The effectiveness of it has been well documented during the long-term clinical practices． In our study，the effects and the possible active mechanisms of LW on learning and memory ，neuroendocrine and immune functions were studies from the angle of neuroendocrine immunomodulation （NIM） network．In chemical fractionation and purification of the immunoactive fractions or components contained in LW，the method of a close collaboration between pharmacological and chemical studies was employed ．The chemical fractionation was begun from the decoction and guided by pharmacological activity evaluation． The results showed that oral administration of LW significantly improved learning and memory abilities in several kinds of model animals such as senescence accelerated mice (SAM)，chronic hanging stress-loaded mice and corticosterone-treated mice and the mechanism studies suggested that the effects were achieved through several ways．LW significantly decreased the plasma level of corticosterone in SAM-prone/8 (SAMP8)，a substrain of SAM．SAMP8 showed a marked elevation of plasma level of corticosterone with advancing age in comparison with SAMR1， a substrain of senescence resistant of SAM．LW also significantly improved the secretion of testosterone by primary cultured testis cells from SAMP8．The immunopharmacological studies showed that oral administration of LW not only improved the immune functions in several immunode展开更多
文摘Liuwei Dihuang decoction（LW），a classical traditional Chinese medicinal prescription with the effect of “nourishing Kidney-Yin”，consists of six herbs including Rehmannia glutinosa (Shudi),Cornus officinalis(Shauzhuyu)，Dioscorea opposita(Shanyao)，Alisma orientale(Zexie)，Porie cocos （Fuling）and Paeonia suffruticosa （Mudanpi）．It has long been used clinically in the treatments of many kinds of diseases with the sign of “Kidney-Yin deficiency”，such as cancer ，diabetes，autoimmue diseases， menopausal syndrome in traditional Chinese medical treatments．The effectiveness of it has been well documented during the long-term clinical practices． In our study，the effects and the possible active mechanisms of LW on learning and memory ，neuroendocrine and immune functions were studies from the angle of neuroendocrine immunomodulation （NIM） network．In chemical fractionation and purification of the immunoactive fractions or components contained in LW，the method of a close collaboration between pharmacological and chemical studies was employed ．The chemical fractionation was begun from the decoction and guided by pharmacological activity evaluation． The results showed that oral administration of LW significantly improved learning and memory abilities in several kinds of model animals such as senescence accelerated mice (SAM)，chronic hanging stress-loaded mice and corticosterone-treated mice and the mechanism studies suggested that the effects were achieved through several ways．LW significantly decreased the plasma level of corticosterone in SAM-prone/8 (SAMP8)，a substrain of SAM．SAMP8 showed a marked elevation of plasma level of corticosterone with advancing age in comparison with SAMR1， a substrain of senescence resistant of SAM．LW also significantly improved the secretion of testosterone by primary cultured testis cells from SAMP8．The immunopharmacological studies showed that oral administration of LW not only improved the immune functions in several immunode
