Background Premature ventricular contraction （PVC） is one of the most common kinds of arrhythmias for which the treatment falls into dilemma. Previous clinical application showed that the traditional Chinese Medicin...Background Premature ventricular contraction （PVC） is one of the most common kinds of arrhythmias for which the treatment falls into dilemma. Previous clinical application showed that the traditional Chinese Medicine Shensongyangxin （SSYX） capsule is efficacious for the treatment of PVCs. This randomized clinical trial aimed to further evaluate the efficacy and safety of SSYX capsule on treating PVC. Methods The subjects who had frequent PVCs with or without organic heart disease and normal cardiac function were enrolled in the study. The primary endpoint was the change of PVC numbers after eight-week medication with SSYX capsule. The secondary endpoints included change of clinical symptoms related to PVCs and the safety evaluation of SSYX capsule. Totally 188 PVC patients were randomly enrolled in the non-organic heart disease PVCs trial and orally took either $SYX capsules or analogues （three times per day, 4 capsules one time）. A total of 671 PVCs patients were randomly enrolled in the organic heart disease PVCs trial, and orally took either SSYX capsules （three times per day, 4 capsules one time） or mexiletine tablet （three times per day, 150 mg one time）. The PVCs were monitored and calculated with 24-hour Holter electrocardiogram. Routine blood, liver and kidney function were tested before and after medication with SSYX capsule. Results SSYX capsules significantly decreased the PVCs numbers and alleviated the related symptoms in patients with or without organic heart disease. In non-organic heart disease group, SSYX capsules and the placebos decreased the PVCs from 12561.34±9777.93 to 4806.87±6507.17, and 12 605.69±8736.34 to 10364.94±9903.41, respectively. The total effective rate was 74.2% and 28.9% in SSYX and placebo groups （P〈0.001）. In organic heart disease group, SSYX capsule and mexiletine decreased the PVCs from 8641.01±8923.57 to 3853.68±7096.42, 8621.61±8367.74 to 5648.29±8667.38, respectively, The total effective rate was 65.8% and 50.7% in SSYX and mexiletine g展开更多
目的观察子午流注纳子法联合眼罩热敷治疗室性早搏伴失眠的临床疗效。方法将室性早搏伴失眠患者120例,随机分为治疗组、对照组1、对照组2、对照组3,每组30例。治疗组给予子午流注纳子法逢时开穴联合中药安神护目眼罩热敷治疗,对照组1给...目的观察子午流注纳子法联合眼罩热敷治疗室性早搏伴失眠的临床疗效。方法将室性早搏伴失眠患者120例,随机分为治疗组、对照组1、对照组2、对照组3,每组30例。治疗组给予子午流注纳子法逢时开穴联合中药安神护目眼罩热敷治疗,对照组1给予常规针刺治疗,对照组2给予眼罩热敷治疗,对照组3给予常规针刺联合眼罩热敷治疗。观察各组治疗前后24 h Holter室性早搏次数、匹兹堡睡眠质量指数(PSQI)评分变化,并比较各组治疗15 d后、治疗30 d后的临床疗效。结果治疗组治疗30 d后总有效率为93.3%,均高于对照组1的66.7%,对照组2的63.3%和对照组3的70.0%,差异均具有统计学意义(P<0.05)。治疗组治疗后24 h Holter室性早搏次数、PSQI评分与对照组1、对照组2和对照组3比较,差异均具有统计学意义(P<0.05)。结论对室性早搏伴失眠患者采用子午流注纳子法逢时开穴联合中药安神护目眼罩热敷,可以改善患者的临床症状,临床疗效显著。展开更多
文摘Background Premature ventricular contraction （PVC） is one of the most common kinds of arrhythmias for which the treatment falls into dilemma. Previous clinical application showed that the traditional Chinese Medicine Shensongyangxin （SSYX） capsule is efficacious for the treatment of PVCs. This randomized clinical trial aimed to further evaluate the efficacy and safety of SSYX capsule on treating PVC. Methods The subjects who had frequent PVCs with or without organic heart disease and normal cardiac function were enrolled in the study. The primary endpoint was the change of PVC numbers after eight-week medication with SSYX capsule. The secondary endpoints included change of clinical symptoms related to PVCs and the safety evaluation of SSYX capsule. Totally 188 PVC patients were randomly enrolled in the non-organic heart disease PVCs trial and orally took either $SYX capsules or analogues （three times per day, 4 capsules one time）. A total of 671 PVCs patients were randomly enrolled in the organic heart disease PVCs trial, and orally took either SSYX capsules （three times per day, 4 capsules one time） or mexiletine tablet （three times per day, 150 mg one time）. The PVCs were monitored and calculated with 24-hour Holter electrocardiogram. Routine blood, liver and kidney function were tested before and after medication with SSYX capsule. Results SSYX capsules significantly decreased the PVCs numbers and alleviated the related symptoms in patients with or without organic heart disease. In non-organic heart disease group, SSYX capsules and the placebos decreased the PVCs from 12561.34±9777.93 to 4806.87±6507.17, and 12 605.69±8736.34 to 10364.94±9903.41, respectively. The total effective rate was 74.2% and 28.9% in SSYX and placebo groups （P〈0.001）. In organic heart disease group, SSYX capsule and mexiletine decreased the PVCs from 8641.01±8923.57 to 3853.68±7096.42, 8621.61±8367.74 to 5648.29±8667.38, respectively, The total effective rate was 65.8% and 50.7% in SSYX and mexiletine g
文摘目的观察子午流注纳子法联合眼罩热敷治疗室性早搏伴失眠的临床疗效。方法将室性早搏伴失眠患者120例,随机分为治疗组、对照组1、对照组2、对照组3,每组30例。治疗组给予子午流注纳子法逢时开穴联合中药安神护目眼罩热敷治疗,对照组1给予常规针刺治疗,对照组2给予眼罩热敷治疗,对照组3给予常规针刺联合眼罩热敷治疗。观察各组治疗前后24 h Holter室性早搏次数、匹兹堡睡眠质量指数(PSQI)评分变化,并比较各组治疗15 d后、治疗30 d后的临床疗效。结果治疗组治疗30 d后总有效率为93.3%,均高于对照组1的66.7%,对照组2的63.3%和对照组3的70.0%,差异均具有统计学意义(P<0.05)。治疗组治疗后24 h Holter室性早搏次数、PSQI评分与对照组1、对照组2和对照组3比较,差异均具有统计学意义(P<0.05)。结论对室性早搏伴失眠患者采用子午流注纳子法逢时开穴联合中药安神护目眼罩热敷,可以改善患者的临床症状,临床疗效显著。
