Enzyme immunoassays were developed to evaluate the clinical significance of anti-pre-S1 and anti-pre-S2 antibodies, using the synthetic oligopeptide analogues of pre-S1 and pre-S2 proteins as antigens, and 104 patient...Enzyme immunoassays were developed to evaluate the clinical significance of anti-pre-S1 and anti-pre-S2 antibodies, using the synthetic oligopeptide analogues of pre-S1 and pre-S2 proteins as antigens, and 104 patients with different categories of hepatitis B virus (HBV) infection were tested. The detection rates of anti-pre-S1 and anti-pre-S2 were 100% and 66.7% in acute hepatitis B; 30% and 24% in asymptomatic HBV carriers; an0d 47.2% and 19.4% in chronic active hepatitis respectively. In case of chronic HBV infections, in HBV DNA negative and anti-HBe positive cases, the rates were 52.9% and 29.4%, while in HBV DNA and HBeAg positive cases, they were 33.3% and 8.3%. The results suggest that in acute hepatitis B virus infection anti-pre-S appeared even earlier than anti-HBs and might be the markers for early prognosis of infection recovery. Anti-pre-S might also reflect viral clearance in chronic infection.展开更多
文摘Enzyme immunoassays were developed to evaluate the clinical significance of anti-pre-S1 and anti-pre-S2 antibodies, using the synthetic oligopeptide analogues of pre-S1 and pre-S2 proteins as antigens, and 104 patients with different categories of hepatitis B virus (HBV) infection were tested. The detection rates of anti-pre-S1 and anti-pre-S2 were 100% and 66.7% in acute hepatitis B; 30% and 24% in asymptomatic HBV carriers; an0d 47.2% and 19.4% in chronic active hepatitis respectively. In case of chronic HBV infections, in HBV DNA negative and anti-HBe positive cases, the rates were 52.9% and 29.4%, while in HBV DNA and HBeAg positive cases, they were 33.3% and 8.3%. The results suggest that in acute hepatitis B virus infection anti-pre-S appeared even earlier than anti-HBs and might be the markers for early prognosis of infection recovery. Anti-pre-S might also reflect viral clearance in chronic infection.
