AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance. METHODS...AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance. METHODS: 30 healthy volunteers were divided into two groups: standard diet group (Group 1) 18 cases, free diet group (Group 2)12 cases. Each subjects were subjected to simultaneous 24-hour intragastric pH and spectrophotometric bilirubin concentration monitoring (Bilitec 2000). RESULTS: There was no difference of preprandial phase bilirubin absorbance between two groups. The absorbance of postprandial phase was significantly increased in group 2 than group 1. There was no difference between preprandial phase and postprandial phase absorbance in group 1. Postprandial phase absorbance was significantly higher in group 2. In a comparison of bile reflux with intragastric pH during night time, there were 4 types of reflux: Simultaneous increase in absorbance and pH in only 19.6%, increase in bilirubin with unchanged pH 33.3%, pH increase with unchanged absorbance 36.3%, and both unchanged in 10.8%. Linear regression analysis showed no correlation between percentage total time of pH【4 and percentage total time of absorbance】0.14, r=0.068 P【0.05. CONCLUSION: Because of the dietary effect, high absorbance fluids or foods should be avoided in detection. Intragastric pH and bilirubin monitoring separately predict the presence of duodenal (and/or pancreatic) reflux and bile reflux. They can not substitute for each other. The detection of DGR is improved if the two parameters are combined simultaneously.展开更多
目的应用多普勒超声技术检查餐后高血糖患者的血管肉皮功能,探讨餐后高血糖对动脉粥样硬化的影响。方法选择新诊断2型糖尿病患者46例,采集静脉血测TC、TG、LDL-C、HDL-C、血糖、胰岛素、糖化血红蛋白(HbAlc)、高敏C反应蛋白(high-sensit...目的应用多普勒超声技术检查餐后高血糖患者的血管肉皮功能,探讨餐后高血糖对动脉粥样硬化的影响。方法选择新诊断2型糖尿病患者46例,采集静脉血测TC、TG、LDL-C、HDL-C、血糖、胰岛素、糖化血红蛋白(HbAlc)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP),并行口服葡萄糖耐量试验后测餐后2 h血糖(2 h PG)及餐后2 h胰岛素(2 h INS)。将其结果分为空腹高血糖组(空腹高血糖惠者21例)及餐后高血糖组(餐后高血糖患者25例),同期选择血糖正常者20例作为对照组,测定3组的肱动脉内皮依赖性舒张功能(endothelium-dependent dilation,EDD)。结果餐后高血糖组和空腹高血糖组患者肱动脉EDD、TC、LDL-C、HDL-C、空腹血糖、2 h PG、2 h INS、HbAlc、hs-CRP与对照组比较.差异有统计学意义(P<0.05,P<0.01)。餐后高血糖组患者肱动脉EDD较空腹高血糖组明显降低[(3.58±1.04)%vs(4.86±0.92)%.P<0.01]。多因素逐步回归分析显示,EDD与2 h PG、HbAlc、TC呈明显负相关(r分别为-0.77、-0.61、-0.57,P<0.01)。结论餐后高血糖较空腹高血糖对血管内皮功能危害更大.加强餐后高血糖的控制对延缓动脉粥样硬化更为重要。展开更多
基金the Public Health Ministry Foundation of China,No.06-9602-13
文摘AIM: To assess the diagnostic value of a combination of continuous intragastric pH and bilirubin monitoring in the detection of duodenogastric reflux (DGR), and the effects of diet on the bilirubin absorbance. METHODS: 30 healthy volunteers were divided into two groups: standard diet group (Group 1) 18 cases, free diet group (Group 2)12 cases. Each subjects were subjected to simultaneous 24-hour intragastric pH and spectrophotometric bilirubin concentration monitoring (Bilitec 2000). RESULTS: There was no difference of preprandial phase bilirubin absorbance between two groups. The absorbance of postprandial phase was significantly increased in group 2 than group 1. There was no difference between preprandial phase and postprandial phase absorbance in group 1. Postprandial phase absorbance was significantly higher in group 2. In a comparison of bile reflux with intragastric pH during night time, there were 4 types of reflux: Simultaneous increase in absorbance and pH in only 19.6%, increase in bilirubin with unchanged pH 33.3%, pH increase with unchanged absorbance 36.3%, and both unchanged in 10.8%. Linear regression analysis showed no correlation between percentage total time of pH【4 and percentage total time of absorbance】0.14, r=0.068 P【0.05. CONCLUSION: Because of the dietary effect, high absorbance fluids or foods should be avoided in detection. Intragastric pH and bilirubin monitoring separately predict the presence of duodenal (and/or pancreatic) reflux and bile reflux. They can not substitute for each other. The detection of DGR is improved if the two parameters are combined simultaneously.
文摘目的应用多普勒超声技术检查餐后高血糖患者的血管肉皮功能,探讨餐后高血糖对动脉粥样硬化的影响。方法选择新诊断2型糖尿病患者46例,采集静脉血测TC、TG、LDL-C、HDL-C、血糖、胰岛素、糖化血红蛋白(HbAlc)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP),并行口服葡萄糖耐量试验后测餐后2 h血糖(2 h PG)及餐后2 h胰岛素(2 h INS)。将其结果分为空腹高血糖组(空腹高血糖惠者21例)及餐后高血糖组(餐后高血糖患者25例),同期选择血糖正常者20例作为对照组,测定3组的肱动脉内皮依赖性舒张功能(endothelium-dependent dilation,EDD)。结果餐后高血糖组和空腹高血糖组患者肱动脉EDD、TC、LDL-C、HDL-C、空腹血糖、2 h PG、2 h INS、HbAlc、hs-CRP与对照组比较.差异有统计学意义(P<0.05,P<0.01)。餐后高血糖组患者肱动脉EDD较空腹高血糖组明显降低[(3.58±1.04)%vs(4.86±0.92)%.P<0.01]。多因素逐步回归分析显示,EDD与2 h PG、HbAlc、TC呈明显负相关(r分别为-0.77、-0.61、-0.57,P<0.01)。结论餐后高血糖较空腹高血糖对血管内皮功能危害更大.加强餐后高血糖的控制对延缓动脉粥样硬化更为重要。
