目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗...目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗时间为3个月;治疗组患者在此基础上给予膦甲酸钠氯化钠注射液250 m L,ivgtt,qd,治疗时间为14 d。观察两组患者根据HPV病毒载量判定的疗效、HPV转阴率、宫颈炎评分、根据宫颈炎评分改善率判定的疗效及不良反应发生情况。结果:治疗组患者根据HPV病毒载量判定的总有效率(94.29%)明显高于对照组(76.67%),差异有统计学意义(P<0.05);治疗组患者HPV转阴率(77.14%)明显高于对照组(36.67%),差异有统计学意义(P<0.05)。两组患者宫颈炎评分均较治疗前明显降低,且治疗组[(1.49±0.70)分]明显低于对照组[(1.97±0.89)分],差异均有统计学意义(P<0.05);治疗组患者根据宫颈炎评分改善率判定的总有效率(88.57%)明显高于对照组(73.33%),差异有统计学意义(P<0.05)。两组患者治疗过程中均未见不良反应发生。结论:膦甲酸钠联合重组人干扰素α2b能有效抑制HPV病毒复制、提高HPV转阴率、缓解宫颈炎症状,且安全性较高。展开更多
Human papillomavirus(HPV) genital infection is a very common sexual transmitted disease.Mostly,the infection is transient and asymptomatic.The induction of effective immune responses usually allows the infection to be...Human papillomavirus(HPV) genital infection is a very common sexual transmitted disease.Mostly,the infection is transient and asymptomatic.The induction of effective immune responses usually allows the infection to be spontaneously cured.However,the infection sometimes can be responsible for an intraepithelial lesion,which may progress to be cervical cancer.Cervical cancer is one of the most common neoplastic diseases affecting women.It is clear that carcinogenic HPV infection is the necessary process for the development of cervical cancer.HPV infection is very frequent in young women aged less than 25 years and viral clearance lasts for 8 months in average.This clearance is the consequence of host immunity intervention,which leads to spontaneous regression of infection and the overwhelming majority of low-grade squamous intraepithelial lesions(more than 80% within a period of 2 years).The major factor,which permits the progression to high grade squamous intraepithelial lesions and invasive cervical cancer,is the persistent feature of HPV infection.HPV infection is usually transient,but several factors were identified as host factors(genetic,immunodepression,oral contraception and smoking) and viral factors(genotype,variants,viral load and integration) to increase the persistence.Cervical cancer is clearly the first virus-induced solid tumor discovered in human.Furthermore,it represents a woman death cause that can be avoided.展开更多
Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices,...Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, bioffim formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for hiofilm inhihitors will be discussed in this mini-review.展开更多
文摘目的:观察膦甲酸钠联合重组人干扰素α2b治疗宫颈人乳头瘤病毒(HPV)持续感染的临床疗效。方法:选取宫颈HPV持续感染患者65例,按照随机数字表法分为治疗组(n=35)和对照组(n=30)。两组患者均给予重组人干扰素α2b栓10万IU,qod(睡前),治疗时间为3个月;治疗组患者在此基础上给予膦甲酸钠氯化钠注射液250 m L,ivgtt,qd,治疗时间为14 d。观察两组患者根据HPV病毒载量判定的疗效、HPV转阴率、宫颈炎评分、根据宫颈炎评分改善率判定的疗效及不良反应发生情况。结果:治疗组患者根据HPV病毒载量判定的总有效率(94.29%)明显高于对照组(76.67%),差异有统计学意义(P<0.05);治疗组患者HPV转阴率(77.14%)明显高于对照组(36.67%),差异有统计学意义(P<0.05)。两组患者宫颈炎评分均较治疗前明显降低,且治疗组[(1.49±0.70)分]明显低于对照组[(1.97±0.89)分],差异均有统计学意义(P<0.05);治疗组患者根据宫颈炎评分改善率判定的总有效率(88.57%)明显高于对照组(73.33%),差异有统计学意义(P<0.05)。两组患者治疗过程中均未见不良反应发生。结论:膦甲酸钠联合重组人干扰素α2b能有效抑制HPV病毒复制、提高HPV转阴率、缓解宫颈炎症状,且安全性较高。
文摘Human papillomavirus(HPV) genital infection is a very common sexual transmitted disease.Mostly,the infection is transient and asymptomatic.The induction of effective immune responses usually allows the infection to be spontaneously cured.However,the infection sometimes can be responsible for an intraepithelial lesion,which may progress to be cervical cancer.Cervical cancer is one of the most common neoplastic diseases affecting women.It is clear that carcinogenic HPV infection is the necessary process for the development of cervical cancer.HPV infection is very frequent in young women aged less than 25 years and viral clearance lasts for 8 months in average.This clearance is the consequence of host immunity intervention,which leads to spontaneous regression of infection and the overwhelming majority of low-grade squamous intraepithelial lesions(more than 80% within a period of 2 years).The major factor,which permits the progression to high grade squamous intraepithelial lesions and invasive cervical cancer,is the persistent feature of HPV infection.HPV infection is usually transient,but several factors were identified as host factors(genetic,immunodepression,oral contraception and smoking) and viral factors(genotype,variants,viral load and integration) to increase the persistence.Cervical cancer is clearly the first virus-induced solid tumor discovered in human.Furthermore,it represents a woman death cause that can be avoided.
文摘Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, bioffim formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for hiofilm inhihitors will be discussed in this mini-review.
