Objective:Urethral stricture is a highly prevalent disease and has a continued ris-ing incidence.The global burden of disease keeps rising as there are significant rates of recur-rence with the existing management opt...Objective:Urethral stricture is a highly prevalent disease and has a continued ris-ing incidence.The global burden of disease keeps rising as there are significant rates of recur-rence with the existing management options with the need for additional repeat procedures.Moreover,the existing treatment options are associated with significant morbidity in the pa-tient.Long segment urethral strictures are most commonly managed by augmentation urethro-plasty.We explored the potential for the application of an acellular tissue engineered bovine pericardial patch in augmentation urethroplasty in a series of our patients suffering from ure-thral stricture disease.The decreased morbidity due to the avoidance of harvest of buccal mu-cosa,decreased operative time and satisfactory postoperative results make it a promising option for augmentation urethroplasty.Methods:Nine patients with long segment anterior urethral strictures(involving penile and/or bulbar urethra and stricture length>4 cm)were included in the study after proper informed consent was obtained.Acellular tissue engineered indigenous bovine pericardial patch was used for urethroplasty using dorsal onlay technique.Results:A total of nine patients underwent tissue engineered indigenous pericardial patch ur-ethroplasty for long segment urethral strictures,mostly catheter injury induced or associated with balanitis xerotica obliterans.Median follow-up was 8 months(range:2-12 months).Out of nine patients,eight(88.9%)were classifed as success and one(11.1%)was classified as fail-ure.Conclusion:Our study brings a product of tissue engineering,already being used in the cardio-vascular surgery domain,into the urological surgery operating room with satisfactory results achieved using standard operating techniques of one stage urethroplasty.展开更多
目的研究带单瓣自体心包补片在右心室流出道重建术中的应用价值。方法 2006-07/2010-12月期间收治的48例复杂先天性心脏病患者行右心室流出道重建手术,其中法洛四联症（tetralogy of Fallot,TOF）21例,法洛四联症合并肺动脉闭锁（pulmon...目的研究带单瓣自体心包补片在右心室流出道重建术中的应用价值。方法 2006-07/2010-12月期间收治的48例复杂先天性心脏病患者行右心室流出道重建手术,其中法洛四联症（tetralogy of Fallot,TOF）21例,法洛四联症合并肺动脉闭锁（pulmonary atresia,TOF＋PA）12例,右心室双出口合并肺动脉瓣狭窄（double outlet right ventricleand pulmonary stenosis,DORV＋PS）10例,永存动脉干（persistent truncus arteriosus,PTA）5例;男30例,女18例,年龄0.8~16.0（5.2±4.1）岁;术中采用自体心包补片加宽右室流出道,再剪一小块半圆形心包设计成单瓣,缝制于心包补片上,其直径相当于重建后肺动脉瓣环直径。术后随访39例,9例失访,时间2~36（17.1±9.5）月。结果术后无死亡患者,无右室流出道再狭窄,超声显示术后早期血液动力学效果满意;但术后2年只有20%（2/10）患者仍保存正常的肺动脉瓣功能。结论采用带单瓣自体心包补片行右室流出道重建术,操作简便、安全,术后早期能极好的阻止肺动脉瓣返流,其作用虽不能持久,但远期也不会出现右室流出道再狭窄,适当选用能降低围手术期损伤。展开更多
文摘Objective:Urethral stricture is a highly prevalent disease and has a continued ris-ing incidence.The global burden of disease keeps rising as there are significant rates of recur-rence with the existing management options with the need for additional repeat procedures.Moreover,the existing treatment options are associated with significant morbidity in the pa-tient.Long segment urethral strictures are most commonly managed by augmentation urethro-plasty.We explored the potential for the application of an acellular tissue engineered bovine pericardial patch in augmentation urethroplasty in a series of our patients suffering from ure-thral stricture disease.The decreased morbidity due to the avoidance of harvest of buccal mu-cosa,decreased operative time and satisfactory postoperative results make it a promising option for augmentation urethroplasty.Methods:Nine patients with long segment anterior urethral strictures(involving penile and/or bulbar urethra and stricture length>4 cm)were included in the study after proper informed consent was obtained.Acellular tissue engineered indigenous bovine pericardial patch was used for urethroplasty using dorsal onlay technique.Results:A total of nine patients underwent tissue engineered indigenous pericardial patch ur-ethroplasty for long segment urethral strictures,mostly catheter injury induced or associated with balanitis xerotica obliterans.Median follow-up was 8 months(range:2-12 months).Out of nine patients,eight(88.9%)were classifed as success and one(11.1%)was classified as fail-ure.Conclusion:Our study brings a product of tissue engineering,already being used in the cardio-vascular surgery domain,into the urological surgery operating room with satisfactory results achieved using standard operating techniques of one stage urethroplasty.
