AIM To establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).METHODS In the present study, ALPPS, parti...AIM To establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).METHODS In the present study, ALPPS, partial hepatecotmy(PHx), and sham rat models were established initially, which were validated by significant increase of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1. In the setting of accelerated proliferation in volume at the second and fifth day after ALPPS, the characteristics of newborn hepatocytes, as well as specific markers of progenitor hepatic cell, were identified. Afterwards, the detection of liver function followed by cluster analysis of functional gene expression were performed to evaluate the maturity.RESULTS Compared with PHx and sham groups, the proliferation of f LR was significantly higher in ALPPS group(P = 0.023 and 0.001 at second day, P = 0.034 and P < 0.001 at fifth day after stage I). Meanwhile, the increased expression of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1 verified the accelerated liver regeneration derived from ALPPS procedure. However, ALPPS-induced Sox9 positive hepatocytes significantly increased beyond the portal triad, which indicated the progenitor hepatic cell was potentially involved. And the characteristics of ALPPSinduced hepatocytes indicated the lower expression of hepatocyte nuclear factor 4 and anti-tryptase in early proliferative stage. Both suggested the immaturity of ALPPS-derived liver regeneration. Additionally, the detection of liver function and functional genes expression confirmed the immaturity of renascent hepatocytes derived in early stage of ALPPS-derived liver regeneration.CONCLUSION Our study revealed the immaturity of ALPPS-derived proliferation in early regenerative response, which indicated that the volumetric assessment overestimated the functional proliferation. This could be convincing evidence that the stage Ⅱ of ALPPS should be performed prude展开更多
目的:从我国卫生体系出发,探索维布妥昔单抗联合化疗对比单独化疗治疗CD30阳性外周T细胞淋巴瘤(peripheral T cell lymphoma,PTCL)患者的经济性。方法:以ECHELON-2试验及相关文献数据为基础,构建三状态分区生存模型,模型周期为21 d,模...目的:从我国卫生体系出发,探索维布妥昔单抗联合化疗对比单独化疗治疗CD30阳性外周T细胞淋巴瘤(peripheral T cell lymphoma,PTCL)患者的经济性。方法:以ECHELON-2试验及相关文献数据为基础,构建三状态分区生存模型,模型周期为21 d,模拟时限为10年。以质量调整生命年(quality-adjusted life years,QALYs)作为产出指标,评价两方案的经济性,并通过单因素敏感性和概率敏感性分析验证结果。结果:基础分析结果显示,维布妥昔单抗联合环磷酰胺、阿霉素、泼尼松(A+CHP)方案的成本与效用均高于环磷酰胺、阿霉素、长春新碱、泼尼松(CHOP)方案,ICER值为95069.05元/QALY,远低于意愿支付阈值,证明具有经济性。单因素敏感性分析结果表明成本贴现率、效用贴效率、PFS效用值、维布妥昔单抗成本等对ICER影响较大。概率敏感性分析验证了基础分析结果的稳健性。结论:在3倍2023年我国人均国内生产总值(GDP,即268047元)的支付阈值下,维布妥昔单抗联合化疗治疗CD30阳性PTCL具有经济性。展开更多
Query efficiency is bottleneck of XML data cube aggregate query. pXCube is a kind of XML data cube model based on path calculation. Join operations are avoided in this model, but the query efficiency of fact cell is b...Query efficiency is bottleneck of XML data cube aggregate query. pXCube is a kind of XML data cube model based on path calculation. Join operations are avoided in this model, but the query efficiency of fact cell is become a new bottleneck. This paper focuses on parallel technology of cloud computing to improve query efficiency of pXCube. Mixed partitioning strategy for fact and dimensions is applied in pXCube cloud model, and the same partitioned vector is adopted. Query parallel algorithm of pXCube cloud model is presented as well. Experiments show that the query cost of pXCube cloud model decreases with the increasing number of parallel nodes gradually. The query cost of fact fragments of each node are close to or even lower than join operations of dimensions, and the Speedup is with better linear. So the model is well suited for decision supported query.展开更多
Region partition(RP) is the key technique to the finite element parallel computing(FEPC),and its performance has a decisive influence on the entire process of analysis and computation.The performance evaluation index ...Region partition(RP) is the key technique to the finite element parallel computing(FEPC),and its performance has a decisive influence on the entire process of analysis and computation.The performance evaluation index of RP method for the three-dimensional finite element model(FEM) has been given.By taking the electric field of aluminum reduction cell(ARC) as the research object,the performance of two classical RP methods,which are Al-NASRA and NGUYEN partition(ANP) algorithm and the multi-level partition(MLP) method,has been analyzed and compared.The comparison results indicate a sound performance of ANP algorithm,but to large-scale models,the computing time of ANP algorithm increases notably.This is because the ANP algorithm determines only one node based on the minimum weight and just adds the elements connected to the node into the sub-region during each iteration.To obtain the satisfied speed and the precision,an improved dynamic self-adaptive ANP(DSA-ANP) algorithm has been proposed.With consideration of model scale,complexity and sub-RP stage,the improved algorithm adaptively determines the number of nodes and selects those nodes with small enough weight,and then dynamically adds these connected elements.The proposed algorithm has been applied to the finite element analysis(FEA) of the electric field simulation of ARC.Compared with the traditional ANP algorithm,the computational efficiency of the proposed algorithm has been shortened approximately from 260 s to 13 s.This proves the superiority of the improved algorithm on computing time performance.展开更多
基金Supported by the Major Scientific and Technological Project of Zhejiang Province,China,No.2015C03026
文摘AIM To establish a rat model for evaluating the maturity of liver regeneration derived from associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).METHODS In the present study, ALPPS, partial hepatecotmy(PHx), and sham rat models were established initially, which were validated by significant increase of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1. In the setting of accelerated proliferation in volume at the second and fifth day after ALPPS, the characteristics of newborn hepatocytes, as well as specific markers of progenitor hepatic cell, were identified. Afterwards, the detection of liver function followed by cluster analysis of functional gene expression were performed to evaluate the maturity.RESULTS Compared with PHx and sham groups, the proliferation of f LR was significantly higher in ALPPS group(P = 0.023 and 0.001 at second day, P = 0.034 and P < 0.001 at fifth day after stage I). Meanwhile, the increased expression of proliferative markers including Ki-67, proliferating cell nuclear antigen, and cyclin D1 verified the accelerated liver regeneration derived from ALPPS procedure. However, ALPPS-induced Sox9 positive hepatocytes significantly increased beyond the portal triad, which indicated the progenitor hepatic cell was potentially involved. And the characteristics of ALPPSinduced hepatocytes indicated the lower expression of hepatocyte nuclear factor 4 and anti-tryptase in early proliferative stage. Both suggested the immaturity of ALPPS-derived liver regeneration. Additionally, the detection of liver function and functional genes expression confirmed the immaturity of renascent hepatocytes derived in early stage of ALPPS-derived liver regeneration.CONCLUSION Our study revealed the immaturity of ALPPS-derived proliferation in early regenerative response, which indicated that the volumetric assessment overestimated the functional proliferation. This could be convincing evidence that the stage Ⅱ of ALPPS should be performed prude
文摘目的:从我国卫生体系出发,探索维布妥昔单抗联合化疗对比单独化疗治疗CD30阳性外周T细胞淋巴瘤(peripheral T cell lymphoma,PTCL)患者的经济性。方法:以ECHELON-2试验及相关文献数据为基础,构建三状态分区生存模型,模型周期为21 d,模拟时限为10年。以质量调整生命年(quality-adjusted life years,QALYs)作为产出指标,评价两方案的经济性,并通过单因素敏感性和概率敏感性分析验证结果。结果:基础分析结果显示,维布妥昔单抗联合环磷酰胺、阿霉素、泼尼松(A+CHP)方案的成本与效用均高于环磷酰胺、阿霉素、长春新碱、泼尼松(CHOP)方案,ICER值为95069.05元/QALY,远低于意愿支付阈值,证明具有经济性。单因素敏感性分析结果表明成本贴现率、效用贴效率、PFS效用值、维布妥昔单抗成本等对ICER影响较大。概率敏感性分析验证了基础分析结果的稳健性。结论:在3倍2023年我国人均国内生产总值(GDP,即268047元)的支付阈值下,维布妥昔单抗联合化疗治疗CD30阳性PTCL具有经济性。
基金supported by National Natural Science Foundation of China under Grant No. 61072091
文摘Query efficiency is bottleneck of XML data cube aggregate query. pXCube is a kind of XML data cube model based on path calculation. Join operations are avoided in this model, but the query efficiency of fact cell is become a new bottleneck. This paper focuses on parallel technology of cloud computing to improve query efficiency of pXCube. Mixed partitioning strategy for fact and dimensions is applied in pXCube cloud model, and the same partitioned vector is adopted. Query parallel algorithm of pXCube cloud model is presented as well. Experiments show that the query cost of pXCube cloud model decreases with the increasing number of parallel nodes gradually. The query cost of fact fragments of each node are close to or even lower than join operations of dimensions, and the Speedup is with better linear. So the model is well suited for decision supported query.
基金Project(61273187)supported by the National Natural Science Foundation of ChinaProject(61321003)supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China
文摘Region partition(RP) is the key technique to the finite element parallel computing(FEPC),and its performance has a decisive influence on the entire process of analysis and computation.The performance evaluation index of RP method for the three-dimensional finite element model(FEM) has been given.By taking the electric field of aluminum reduction cell(ARC) as the research object,the performance of two classical RP methods,which are Al-NASRA and NGUYEN partition(ANP) algorithm and the multi-level partition(MLP) method,has been analyzed and compared.The comparison results indicate a sound performance of ANP algorithm,but to large-scale models,the computing time of ANP algorithm increases notably.This is because the ANP algorithm determines only one node based on the minimum weight and just adds the elements connected to the node into the sub-region during each iteration.To obtain the satisfied speed and the precision,an improved dynamic self-adaptive ANP(DSA-ANP) algorithm has been proposed.With consideration of model scale,complexity and sub-RP stage,the improved algorithm adaptively determines the number of nodes and selects those nodes with small enough weight,and then dynamically adds these connected elements.The proposed algorithm has been applied to the finite element analysis(FEA) of the electric field simulation of ARC.Compared with the traditional ANP algorithm,the computational efficiency of the proposed algorithm has been shortened approximately from 260 s to 13 s.This proves the superiority of the improved algorithm on computing time performance.
