BACKGROUND Claudin 18.2(CLDN18.2)is a cell surface protein expressed by gastric cancer cells.The monoclonal antibody zolbetuximab binds CLDN18.2-positive cancer cells and causes cancer cell death.A few studies researc...BACKGROUND Claudin 18.2(CLDN18.2)is a cell surface protein expressed by gastric cancer cells.The monoclonal antibody zolbetuximab binds CLDN18.2-positive cancer cells and causes cancer cell death.A few studies researched the prognostic effect of CLDN18.2 expression in metastatic gastric adenocarcinoma.AIM To identify the prognostic value of CLDN18.2 expression in patients with metastatic gastric adenocarcinoma.METHODS This study was conducted with 65 patients over the age of 18 who were diagnosed with metastatic gastric adenocarcinoma.We investigated the effect of CLDN18.2 expression on clinicopathological characteristics(age,sex,histological grade,Lauren classification,family history,metastatic site,HER2 expression)and prognosis for patients with metastatic gastric adenocarcinoma.RESULTS CLDN18.2 expression was positive in 73.8%(48)of the patients.During the median 17.7-mo follow-up period,89.2%(58)of the patients died.Median progression-free survival and overall survival(OS)were 6 mo(95%confidence interval:1.6-10.4)and 12 mo(95%confidence interval:7.5-16.5).There was no statistically significant correlation between CLDN18.2 expression and clinicopathological characteristics of the patients.In univariate and multivariate Cox regression analysis,there was no correlation between clinicopathological characteristics of patients and progression-free survival or OS.CONCLUSION CLDN18.2 expression was quite high in patients with gastric adenocarcinoma,identifying the proportion of the patients in whom zolbetuximab would be efficacious.There is no statistically significant correlation with clinicopathological characteristics and OS.CLDN18.2 is not a prognostic marker in patients with gastric adenocarcinoma,although it is predictive.展开更多
The overall carbonation of MgO-admixed soil provides not only an efficient and environmentally friendly technique for improving soft ground but also a permanently safe solution for CO_(2) sequestration.To evaluate the...The overall carbonation of MgO-admixed soil provides not only an efficient and environmentally friendly technique for improving soft ground but also a permanently safe solution for CO_(2) sequestration.To evaluate the carbon sequestration potential and promote the carbonation application in soil improvement,a laboratory-scale model investigation is designed under pressurized carbonation considering the influences of MgO dosage and CO_(2) ventilation mode(way).The temperature,dynamic resilience modulus,and dynamic cone penetration(DCP)were tested to assess the carbonation treatment effect.The physical,strength,and microscopic tests were also undertaken to reveal the evolution mechanisms of CO_(2) migration in the MgO-carbonated foundation.The results indicate that the temperature peaks of MgO-treated foundation emerge at w20 h during hydration,but occur at a distance of 0e25 cm from the gas source within 6 h during carbonation.The dynamic resilience moduli of the model foundation increase by more than two times after carbonation and the DCP indices reduce dramatically.As the distance from the gas inlet increases,the bearing capacity,strength,and carbon sequestration decrease,whereas the moisture content increases.Compared to the end ventilation,the middle ventilation produces a higher carbonation degree and a wider carbonation area.The cementation and filling of nesquehonite and dypingite/hydromagnesite are verified to be critical factors for carbonation evolution and enhancing mechanical performances.Finally,the overall carbonation model is described schematically in three stages of CO_(2) migration.The outcomes would help to facilitate the practical application of CO_(2) sequestration in soil treatment.展开更多
文摘BACKGROUND Claudin 18.2(CLDN18.2)is a cell surface protein expressed by gastric cancer cells.The monoclonal antibody zolbetuximab binds CLDN18.2-positive cancer cells and causes cancer cell death.A few studies researched the prognostic effect of CLDN18.2 expression in metastatic gastric adenocarcinoma.AIM To identify the prognostic value of CLDN18.2 expression in patients with metastatic gastric adenocarcinoma.METHODS This study was conducted with 65 patients over the age of 18 who were diagnosed with metastatic gastric adenocarcinoma.We investigated the effect of CLDN18.2 expression on clinicopathological characteristics(age,sex,histological grade,Lauren classification,family history,metastatic site,HER2 expression)and prognosis for patients with metastatic gastric adenocarcinoma.RESULTS CLDN18.2 expression was positive in 73.8%(48)of the patients.During the median 17.7-mo follow-up period,89.2%(58)of the patients died.Median progression-free survival and overall survival(OS)were 6 mo(95%confidence interval:1.6-10.4)and 12 mo(95%confidence interval:7.5-16.5).There was no statistically significant correlation between CLDN18.2 expression and clinicopathological characteristics of the patients.In univariate and multivariate Cox regression analysis,there was no correlation between clinicopathological characteristics of patients and progression-free survival or OS.CONCLUSION CLDN18.2 expression was quite high in patients with gastric adenocarcinoma,identifying the proportion of the patients in whom zolbetuximab would be efficacious.There is no statistically significant correlation with clinicopathological characteristics and OS.CLDN18.2 is not a prognostic marker in patients with gastric adenocarcinoma,although it is predictive.
基金funding provided by the National Science Foundation of China(Grant No.41902286)the Open Fund for the State Key Laboratory of Geomechanics and Geotechnical Engineering(Grant No.SKLGME021029)the CRSRI Open Research Program(Grant No.CKWV20221015/KY).
文摘The overall carbonation of MgO-admixed soil provides not only an efficient and environmentally friendly technique for improving soft ground but also a permanently safe solution for CO_(2) sequestration.To evaluate the carbon sequestration potential and promote the carbonation application in soil improvement,a laboratory-scale model investigation is designed under pressurized carbonation considering the influences of MgO dosage and CO_(2) ventilation mode(way).The temperature,dynamic resilience modulus,and dynamic cone penetration(DCP)were tested to assess the carbonation treatment effect.The physical,strength,and microscopic tests were also undertaken to reveal the evolution mechanisms of CO_(2) migration in the MgO-carbonated foundation.The results indicate that the temperature peaks of MgO-treated foundation emerge at w20 h during hydration,but occur at a distance of 0e25 cm from the gas source within 6 h during carbonation.The dynamic resilience moduli of the model foundation increase by more than two times after carbonation and the DCP indices reduce dramatically.As the distance from the gas inlet increases,the bearing capacity,strength,and carbon sequestration decrease,whereas the moisture content increases.Compared to the end ventilation,the middle ventilation produces a higher carbonation degree and a wider carbonation area.The cementation and filling of nesquehonite and dypingite/hydromagnesite are verified to be critical factors for carbonation evolution and enhancing mechanical performances.Finally,the overall carbonation model is described schematically in three stages of CO_(2) migration.The outcomes would help to facilitate the practical application of CO_(2) sequestration in soil treatment.
