Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of...Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods： One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results： Ostealgia degree did not change significantly after diphosphonates treatment from one to two months （P 〉 0.05）. The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month （54%） and two months （56%） were significantly increased than that before treatment （36%） （X2 = 6.55, P = 0.011; X2 = 8.05, P = 0.005）. Serum calcium and serum phosphorus were both decreased after treatment one month （t = 4.39, P = 0.000; t = 2.50, P = 0.014） and two months （t = 4.32, P = 0.000; t = 2.49, P = 0.010）. There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion： Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus.展开更多
Acute myeloid leukemia(AML)is a form of cancer characterized by infiltration of proliferative,clonal,and abnormally differentiated cells of the hematopoietic system into the bone marrow,blood,and other tissues.Clinica...Acute myeloid leukemia(AML)is a form of cancer characterized by infiltration of proliferative,clonal,and abnormally differentiated cells of the hematopoietic system into the bone marrow,blood,and other tissues.Clinically,the eligible AML patients first receive induction therapy to achieve complete remission(CR).Unfortunately,minimal residual diseases usually persist in CR,which will inevitably lead to relapse if treatment is discontinued.In traditional Chinese medicine(TCM),it is believed that the weakness of healthy qi is one of the basic pathologies of leukemia after remission,and is also the major cause for relapse.This article primarily investigated the key points of common syndromes,TCM nursing methods and healthy guidance of AML,aiming at maintaining and developing the strengths of TCM,improving its efficacy and standardizing its behavior.展开更多
基金Supported by grants from the Minhang District Science and Technology Foundation and Health Bureau Foundation (No. 2008MW23, 2009MW17, 2010MHZ042)
文摘Objective： Bisphosphonates were widely used with the rate of malignant tumor with bone metastases increasing rapidly. The aim of this study was to evaluate zoledronic acid and pamidronic acid on treating ostealgia of malignant tumor with bone metastases and serum calcium, phosphorus and alkaline phosphorus movement. Methods： One Hundred cancer patients with bone metastases were diagnosed according to pathological and imaging methods. After zoledronic acid or pamidronic acid intravenous infusion one and two months, ostealgia degree, serum calcium, serum phosphorus and alkaline phosphorus were observed before bisphosphonates treatment, one and two months after treatment, respectively. Results： Ostealgia degree did not change significantly after diphosphonates treatment from one to two months （P 〉 0.05）. The linear correlation between serum calcium and serum phosphorus on bone metastases cancer patients before therapy was dismissed after bisphosphonates treatment one month and did not recover in two months. The incidence of hypo-calcium after diphosphonate treatment one month （54%） and two months （56%） were significantly increased than that before treatment （36%） （X2 = 6.55, P = 0.011; X2 = 8.05, P = 0.005）. Serum calcium and serum phosphorus were both decreased after treatment one month （t = 4.39, P = 0.000; t = 2.50, P = 0.014） and two months （t = 4.32, P = 0.000; t = 2.49, P = 0.010）. There had no difference between zoledronic acid and pamidronic acid on treating of ostealgia and serum calcium and phosphorus changing. Conclusion： Zoledronic acid and pamidronic acid can relief ostealgia of cancer patients with bone metastases and induce hypo-calcium, break the linear relationship between calcium and phosphorus. There have no difference between zoledronic acid and pamidronic acid on treating ostealgia and inducing hypo-calcium and hypo-phosphorus.
文摘Acute myeloid leukemia(AML)is a form of cancer characterized by infiltration of proliferative,clonal,and abnormally differentiated cells of the hematopoietic system into the bone marrow,blood,and other tissues.Clinically,the eligible AML patients first receive induction therapy to achieve complete remission(CR).Unfortunately,minimal residual diseases usually persist in CR,which will inevitably lead to relapse if treatment is discontinued.In traditional Chinese medicine(TCM),it is believed that the weakness of healthy qi is one of the basic pathologies of leukemia after remission,and is also the major cause for relapse.This article primarily investigated the key points of common syndromes,TCM nursing methods and healthy guidance of AML,aiming at maintaining and developing the strengths of TCM,improving its efficacy and standardizing its behavior.
