One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes f...One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.展开更多
Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of opt...Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy.展开更多
在高分辨率光学遥感成像过程中,卫星平台的不稳定性将影响相机成像质量。针对该问题,在分析动态降质机理的基础上分别就面阵凝视模式、线阵推扫模式及时间延迟积分(Time Delay and Integration,TDI)推扫模式提出了相应的动态成像仿真模...在高分辨率光学遥感成像过程中,卫星平台的不稳定性将影响相机成像质量。针对该问题,在分析动态降质机理的基础上分别就面阵凝视模式、线阵推扫模式及时间延迟积分(Time Delay and Integration,TDI)推扫模式提出了相应的动态成像仿真模型,以此模拟不同情况下的退化结果。以高分辨率遥感相机为对象,开展多种情况下的仿真试验分析。结果表明,同等平台运动条件下,TDI推扫模式下的图像质量下降更明显;分辨率越高,像质对平台振动的响应灵敏度越高。最后结合仿真模型及图像评价参量,建立起空间分辨率与平台颤振指标之间的关系,给出不同空间分辨率下的平台运动误差阈值,为平台振动抑制和补偿提供约束条件。展开更多
基金supported by the Fundamental Research Funds for the Central Universities and East China University of Science and Technology (start-up funds, Wei Wang)the China 111 Project (Grant B07023, Wei Wang)
文摘One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence(NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review,we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.
基金supported by the National Science Foundation of China(No.21577037 to Kaiyan Lou)East China University of Science and Technology(Grant No.YC0140101,start-up funds to Wei Wang)
文摘Multimodality optical imaging probes have emerged as powerful tools that improve detection sensitivity and accuracy, important in disease diagnosis and treatment. In this review, we focus on recent developments of optical fluorescence imaging(OFI) probe integration with other imaging modalities such as X-ray computed tomography(CT), magnetic resonance imaging(MRI), positron emission tomography(PET), single-photon emission computed tomography(SPECT), and photoacoustic imaging(PAI). The imaging technologies are briefly described in order to introduce the strengths and limitations of each techniques and the need for further multimodality optical imaging probe development. The emphasis of this account is placed on how design strategies are currently implemented to afford physicochemically and biologically compatible multimodality optical fluorescence imaging probes. We also present studies that overcame intrinsic disadvantages of each imaging technique by multimodality approach with improved detection sensitivity and accuracy.
文摘在高分辨率光学遥感成像过程中,卫星平台的不稳定性将影响相机成像质量。针对该问题,在分析动态降质机理的基础上分别就面阵凝视模式、线阵推扫模式及时间延迟积分(Time Delay and Integration,TDI)推扫模式提出了相应的动态成像仿真模型,以此模拟不同情况下的退化结果。以高分辨率遥感相机为对象,开展多种情况下的仿真试验分析。结果表明,同等平台运动条件下,TDI推扫模式下的图像质量下降更明显;分辨率越高,像质对平台振动的响应灵敏度越高。最后结合仿真模型及图像评价参量,建立起空间分辨率与平台颤振指标之间的关系,给出不同空间分辨率下的平台运动误差阈值,为平台振动抑制和补偿提供约束条件。
