AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patien...AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 展开更多
Thermomechanical damage of nodules in dielectric multilayer coatings that are irradiated by nanosecond laser pulses has been interpreted with respect to mechanical properties and electric-field enhancement.However,the...Thermomechanical damage of nodules in dielectric multilayer coatings that are irradiated by nanosecond laser pulses has been interpreted with respect to mechanical properties and electric-field enhancement.However,the effect of electric-field enhancement in nodular damage,especially the influence of electric-field distributions,has never been directly demonstrated through experimental results,which prevents the achievement of a clear understanding of the damage process of nodular defects.Here,a systematic and comparative study was designed to reveal how electric-field distributions affect the damage behavior of nodules.To obtain reliable results,two series of artificial nodules with different geometries and film absorption characteristics were prepared from monodisperse silica microspheres.After establishing simplified geometrical models of the nodules,the electric-field enhancement was simulated using a three-dimensional finite-difference time-domain code.Then,the damage morphologies of the artificial nodules were directly compared with the simulated electric-field intensity profiles.For both series of nodules,the damage morphologies reproduced our simulated electric-field intensity distributions very well.These results indicated that the electric-field distribution was actually a bridge that connected the nodular mechanical properties to the final thermomechanical damage.Understanding of the damage mechanism of nodules was deepened by obtaining data on the influence of electric-field distributions on the damage behavior of nodules.展开更多
The static drill rooted nodular pile is a new type of pile foundation consisting of precast nodular pile and the surrounding cemented soil.This composite pile has a relatively high bearing capacity and the mud polluti...The static drill rooted nodular pile is a new type of pile foundation consisting of precast nodular pile and the surrounding cemented soil.This composite pile has a relatively high bearing capacity and the mud pollution will be largely reduced during the construction process by using this type of pile.In order to investigate the bearing capacity and load transfer mechanism of this pile,a group of experiments were conducted to provide a comparison between this new pile and the bored pile.The axial force of a precast nodular pile was also measured by the strain gauges installed on the pile to analyze the distribution of the axial force of the nodular pile and the skin friction supported by the surrounding soil,then 3D models were built by using the ABAQUS finite element program to investigate the load transfer mechanism of this composite pile in detail.By combining the results of field tests and the finite element method,the outcome showed that the bearing capacity of a static drill rooted nodular pile is higher than the bored pile,and that this composite pile will form a double stress dispersion system which will not only confirm the strength of the pile,but also make the skin friction to be fully mobilized.The settlement of this composite pile is mainly controlled by the precast nodular pile;meanwhile,the nodular pile and the surrounding cemented soil can be considered as deformation compatibility during the loading process.The nodes on the nodular pile play an important role during the load transfer process,the shear strength of the interface between the cemented soil and the soil of the static drill rooted pile is larger than that of the bored pile.展开更多
基金Supported by A Grant of the Korea Healthcare Technology R and D Project,Ministry of Health and Welfare,South Korea, A102065
文摘AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was
基金This work was partly supported by the National Natural Science Foundation of China(Grant Nos.61235011,61008030,61108014,61205124)the ChenGuang Project of Shanghai Municipal Education Commission(Grant No.10CG19)+1 种基金the Specialized Research Fund for the Doctoral Program of High Education(Grant No.20100072120037)the National 863 Program.
文摘Thermomechanical damage of nodules in dielectric multilayer coatings that are irradiated by nanosecond laser pulses has been interpreted with respect to mechanical properties and electric-field enhancement.However,the effect of electric-field enhancement in nodular damage,especially the influence of electric-field distributions,has never been directly demonstrated through experimental results,which prevents the achievement of a clear understanding of the damage process of nodular defects.Here,a systematic and comparative study was designed to reveal how electric-field distributions affect the damage behavior of nodules.To obtain reliable results,two series of artificial nodules with different geometries and film absorption characteristics were prepared from monodisperse silica microspheres.After establishing simplified geometrical models of the nodules,the electric-field enhancement was simulated using a three-dimensional finite-difference time-domain code.Then,the damage morphologies of the artificial nodules were directly compared with the simulated electric-field intensity profiles.For both series of nodules,the damage morphologies reproduced our simulated electric-field intensity distributions very well.These results indicated that the electric-field distribution was actually a bridge that connected the nodular mechanical properties to the final thermomechanical damage.Understanding of the damage mechanism of nodules was deepened by obtaining data on the influence of electric-field distributions on the damage behavior of nodules.
文摘The static drill rooted nodular pile is a new type of pile foundation consisting of precast nodular pile and the surrounding cemented soil.This composite pile has a relatively high bearing capacity and the mud pollution will be largely reduced during the construction process by using this type of pile.In order to investigate the bearing capacity and load transfer mechanism of this pile,a group of experiments were conducted to provide a comparison between this new pile and the bored pile.The axial force of a precast nodular pile was also measured by the strain gauges installed on the pile to analyze the distribution of the axial force of the nodular pile and the skin friction supported by the surrounding soil,then 3D models were built by using the ABAQUS finite element program to investigate the load transfer mechanism of this composite pile in detail.By combining the results of field tests and the finite element method,the outcome showed that the bearing capacity of a static drill rooted nodular pile is higher than the bored pile,and that this composite pile will form a double stress dispersion system which will not only confirm the strength of the pile,but also make the skin friction to be fully mobilized.The settlement of this composite pile is mainly controlled by the precast nodular pile;meanwhile,the nodular pile and the surrounding cemented soil can be considered as deformation compatibility during the loading process.The nodes on the nodular pile play an important role during the load transfer process,the shear strength of the interface between the cemented soil and the soil of the static drill rooted pile is larger than that of the bored pile.
