目的：探讨分析胎膜早破引起新生儿感染的病原菌分布，以降低新生儿感染的发生。方法回顾性分析2008年1月-2012年12月1584例胎膜早破病例的临床资料，其中326例新生儿发生感染，对其进行病原菌检测，采用SPSS 17．0软件对数据进行统计...目的：探讨分析胎膜早破引起新生儿感染的病原菌分布，以降低新生儿感染的发生。方法回顾性分析2008年1月-2012年12月1584例胎膜早破病例的临床资料，其中326例新生儿发生感染，对其进行病原菌检测，采用SPSS 17．0软件对数据进行统计分析。结果326例新生儿中有217例为感染性肺炎，占66．57％，68例为败血症，占20．86％；胎膜早破至出生时间≤12 h者23例、13～72 h 249例、＞72 h 54例，分别占7．06％、76．38％、16．56％；294例新生儿出现感染病灶局部分泌物和血培养阳性，阳性率为90．18％；共培养出病原菌312株，其中革兰阳性菌194株、革兰阴性菌113株、真菌5株，分别占62．18％、36．22％、1．60％；不同的胎膜早破时间与病原菌阳性率之间，差异有统计学意义（ P＜0．05）；237例早产儿病原菌检出率为97．04％，89例足月儿病原菌检出率为71．91％，两者比较，差异有统计学意义（ P＜0．05）。结论胎膜早破与新生儿病原菌感染关系密切，临床应积极做好胎膜早破与新生儿感染的预防与治疗工作。展开更多
Background: Late Neonatal Bacterial Infection (LNNBI) is a clinical and biological manifestations related to penetration and growth of specific causative bacteria in bloodstream occurring on the 4<sup>th</sup...Background: Late Neonatal Bacterial Infection (LNNBI) is a clinical and biological manifestations related to penetration and growth of specific causative bacteria in bloodstream occurring on the 4<sup>th</sup>-28<sup>th</sup> day of life. LNNBI still represents an important cause of mortality and morbidity among infants. Objectives: To determine the frequency of late bacterial infections in newborns, to describe the clinical and biological profiles and to identify the main responsible germs. Methods: Descriptive study data collection, conducted over a period of 10 months at the Brazzaville Teaching Hospital, of interest to newborns admitted from the 4<sup>th</sup> day of life for suspicion of neonatal infection, and those admitted for any other pathology and having presented an infection 48 hours after hospitalization, and in whom a bacterial culture and/or an inflammatory assessment confirmed or suspected infection. Results: During the study period, 1682 newborns were hospitalized, and 86 were hospitalized for a late neonatal bacterial infection, i.e. a frequency of 5.1%. There were 67 (77.9%) community infections and 19 (22.1%) nosocomial infections. The frequency of nosocomial infection was 1.1%. The main signs were fever in 65 cases (75.6%), and respiratory distress in 37 cases (43%). The most frequent localizations were bacteremia 32 (37.2%), pulmonary 21 (24.4%), digestive and meningeal in 11 cases (12.8%) each. The most common germ Klebsiella in 10 (50%) newborns was resistant to the usual antibiotics. The evolution was favorable in 71 cases (82.5%), and death occurred in 12 cases (14%). Conclusion: Late neonatal bacterial infection is common. The main responsible germs are gram-negative bacilli, in particular Klebsiella multi-resistant.展开更多
文摘目的：探讨分析胎膜早破引起新生儿感染的病原菌分布，以降低新生儿感染的发生。方法回顾性分析2008年1月-2012年12月1584例胎膜早破病例的临床资料，其中326例新生儿发生感染，对其进行病原菌检测，采用SPSS 17．0软件对数据进行统计分析。结果326例新生儿中有217例为感染性肺炎，占66．57％，68例为败血症，占20．86％；胎膜早破至出生时间≤12 h者23例、13～72 h 249例、＞72 h 54例，分别占7．06％、76．38％、16．56％；294例新生儿出现感染病灶局部分泌物和血培养阳性，阳性率为90．18％；共培养出病原菌312株，其中革兰阳性菌194株、革兰阴性菌113株、真菌5株，分别占62．18％、36．22％、1．60％；不同的胎膜早破时间与病原菌阳性率之间，差异有统计学意义（ P＜0．05）；237例早产儿病原菌检出率为97．04％，89例足月儿病原菌检出率为71．91％，两者比较，差异有统计学意义（ P＜0．05）。结论胎膜早破与新生儿病原菌感染关系密切，临床应积极做好胎膜早破与新生儿感染的预防与治疗工作。
文摘Background: Late Neonatal Bacterial Infection (LNNBI) is a clinical and biological manifestations related to penetration and growth of specific causative bacteria in bloodstream occurring on the 4<sup>th</sup>-28<sup>th</sup> day of life. LNNBI still represents an important cause of mortality and morbidity among infants. Objectives: To determine the frequency of late bacterial infections in newborns, to describe the clinical and biological profiles and to identify the main responsible germs. Methods: Descriptive study data collection, conducted over a period of 10 months at the Brazzaville Teaching Hospital, of interest to newborns admitted from the 4<sup>th</sup> day of life for suspicion of neonatal infection, and those admitted for any other pathology and having presented an infection 48 hours after hospitalization, and in whom a bacterial culture and/or an inflammatory assessment confirmed or suspected infection. Results: During the study period, 1682 newborns were hospitalized, and 86 were hospitalized for a late neonatal bacterial infection, i.e. a frequency of 5.1%. There were 67 (77.9%) community infections and 19 (22.1%) nosocomial infections. The frequency of nosocomial infection was 1.1%. The main signs were fever in 65 cases (75.6%), and respiratory distress in 37 cases (43%). The most frequent localizations were bacteremia 32 (37.2%), pulmonary 21 (24.4%), digestive and meningeal in 11 cases (12.8%) each. The most common germ Klebsiella in 10 (50%) newborns was resistant to the usual antibiotics. The evolution was favorable in 71 cases (82.5%), and death occurred in 12 cases (14%). Conclusion: Late neonatal bacterial infection is common. The main responsible germs are gram-negative bacilli, in particular Klebsiella multi-resistant.
