Za wine is a kind. of health drink existing. in the South-West-ern minorities. The author in this article believes that the history of Za wine should be tracked back to at least 7000 years ago The author analyses the ...Za wine is a kind. of health drink existing. in the South-West-ern minorities. The author in this article believes that the history of Za wine should be tracked back to at least 7000 years ago The author analyses the unique feature of Za wine from its raw materi-als, procedures in production to its nutritious compositions, and points out that to develop Za wine has a bright fu ture.展开更多
Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CA...Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs indifferent nationalities of China. Five SNPs were chosen to perform case-control study andhaplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. OneSNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmission-disequilibrium test (STDT) in 68 type 2 diabetes pedigrees (377 people). Results A totalof 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. TheSNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different fromthose reported in Mexican American. There was no significantly statistical difference in theallele frequency of the 5 SNPs between case and control, and the haplotype frequencies inthe two groups were not significantly different. No positive results was found in TDT andSTDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in differentnationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility onesof type 2 diabetes mellitus in Han people of Northern China.展开更多
文摘Za wine is a kind. of health drink existing. in the South-West-ern minorities. The author in this article believes that the history of Za wine should be tracked back to at least 7000 years ago The author analyses the unique feature of Za wine from its raw materi-als, procedures in production to its nutritious compositions, and points out that to develop Za wine has a bright fu ture.
基金the National Natural Science Foundation (Grant No. 30170441,39896200)863 High Tech Project (Grant No. 2001AA221161)+2 种基金 National 973 Project (Grant No.G1998051016) Beijing Natural Science Fund (Grant No. 7002026)the National High EducationSci
文摘Objective To investigate the distribution of single nucleotide polymorphisms (SNPs)in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus inHan people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs indifferent nationalities of China. Five SNPs were chosen to perform case-control study andhaplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. OneSNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmission-disequilibrium test (STDT) in 68 type 2 diabetes pedigrees (377 people). Results A totalof 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. TheSNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different fromthose reported in Mexican American. There was no significantly statistical difference in theallele frequency of the 5 SNPs between case and control, and the haplotype frequencies inthe two groups were not significantly different. No positive results was found in TDT andSTDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in differentnationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility onesof type 2 diabetes mellitus in Han people of Northern China.
