BACKGROUND Hemostasis of patients suffering from liver cirrhosis is challenging due to both,pro-and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation.Pathological c...BACKGROUND Hemostasis of patients suffering from liver cirrhosis is challenging due to both,pro-and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation.Pathological changes in conventional coagulation analysis and platelet count are common manifestations of decreased liver synthesis of coagulation factors and reduced platelet count in these patients.However,conventional coagulation analysis and platelet count do not reflect invivo coagulation status or platelet function.The purpose of this present observational study was therefore to assess the haemostatic profile including plasmatic coagulation using thrombelastometry and impedance aggregometry for platelet function in patients suffering from liver cirrhosis.AIM To assess the hemostatic profile of cirrhotic patients according to model for endstage liver disease(MELD)score.METHODS Our study included both in-and outpatients suffering from liver cirrhosis attending the out-and inpatient care of the department of hepatology.Demographic and biochemical data as well as medical history including cause of liver cirrhosis,end stage kidney failure and medication with anticoagulants were recorded.To assess the hemostatic profile,platelet function was analyzed by multiple electrode aggregometry(MEA)using Multiplate^■(ADP-,ASPI-and TRAP-test)and thrombelastometry using ROTEM^■(EXTEM,INTEM,FIBTEM).Data were compared using Mann-Whitney U-or χ^2-test.Spearman correlation was performed to analyze the association between MELD Score and results of thrombelastometry and MEA.RESULTS A total of 68 patients attending the out-and inpatient care suffering from liver cirrhosis were screened.Of these,50 patients were included and assigned to groups according to MELD score 6 to 11(n=25)or≥17(n=25).Baseline patient characteristics revealed significant differences for MELD score(8 vs 22,P<0.0001)and underlying laboratory parameters(international normalized ratio,bilirubine,creatinine)as well as fibrinogen level(275 mg/dL vs 209 mg/dL,展开更多
为深入理解气液两相介质阻挡放电的机理和特征,利用多针–平板电极结构,测量了气液两相DBD的电学和光学放电特性,研究了放电电气参量及放电空间主要粒子强度随外加电压的变化趋势,并根据实验结果建立了放电的等效电路模型,利用其结合放...为深入理解气液两相介质阻挡放电的机理和特征,利用多针–平板电极结构,测量了气液两相DBD的电学和光学放电特性,研究了放电电气参量及放电空间主要粒子强度随外加电压的变化趋势,并根据实验结果建立了放电的等效电路模型,利用其结合放电机理对所得到的结果进行了分析和讨论。结果表明:气液两相DBD的放电与纯气相DBD放电相类似,但还要考虑液体阻抗对放电的影响,其放电电流为阻容性,超前电压的角度<90°。气相放电中产生了大量的N2、O和OH等活性粒子,放电功率、传输电荷和电子密度等主要放电参量均随外加电压的增加而增大,而气隙电容随外加电压增加而减小,外加电压20.5 k V时,它们的值分别为78 W、1 060 n C、1.87×1011 cm-3和8.07 p F,气相放电可用电压控制电流源(VCCS)、电阻和可变电容来等效,而液体可用可变电阻等效,计算得到放电前其值为825?。展开更多
文摘BACKGROUND Hemostasis of patients suffering from liver cirrhosis is challenging due to both,pro-and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation.Pathological changes in conventional coagulation analysis and platelet count are common manifestations of decreased liver synthesis of coagulation factors and reduced platelet count in these patients.However,conventional coagulation analysis and platelet count do not reflect invivo coagulation status or platelet function.The purpose of this present observational study was therefore to assess the haemostatic profile including plasmatic coagulation using thrombelastometry and impedance aggregometry for platelet function in patients suffering from liver cirrhosis.AIM To assess the hemostatic profile of cirrhotic patients according to model for endstage liver disease(MELD)score.METHODS Our study included both in-and outpatients suffering from liver cirrhosis attending the out-and inpatient care of the department of hepatology.Demographic and biochemical data as well as medical history including cause of liver cirrhosis,end stage kidney failure and medication with anticoagulants were recorded.To assess the hemostatic profile,platelet function was analyzed by multiple electrode aggregometry(MEA)using Multiplate^■(ADP-,ASPI-and TRAP-test)and thrombelastometry using ROTEM^■(EXTEM,INTEM,FIBTEM).Data were compared using Mann-Whitney U-or χ^2-test.Spearman correlation was performed to analyze the association between MELD Score and results of thrombelastometry and MEA.RESULTS A total of 68 patients attending the out-and inpatient care suffering from liver cirrhosis were screened.Of these,50 patients were included and assigned to groups according to MELD score 6 to 11(n=25)or≥17(n=25).Baseline patient characteristics revealed significant differences for MELD score(8 vs 22,P<0.0001)and underlying laboratory parameters(international normalized ratio,bilirubine,creatinine)as well as fibrinogen level(275 mg/dL vs 209 mg/dL,
文摘为深入理解气液两相介质阻挡放电的机理和特征,利用多针–平板电极结构,测量了气液两相DBD的电学和光学放电特性,研究了放电电气参量及放电空间主要粒子强度随外加电压的变化趋势,并根据实验结果建立了放电的等效电路模型,利用其结合放电机理对所得到的结果进行了分析和讨论。结果表明:气液两相DBD的放电与纯气相DBD放电相类似,但还要考虑液体阻抗对放电的影响,其放电电流为阻容性,超前电压的角度<90°。气相放电中产生了大量的N2、O和OH等活性粒子,放电功率、传输电荷和电子密度等主要放电参量均随外加电压的增加而增大,而气隙电容随外加电压增加而减小,外加电压20.5 k V时,它们的值分别为78 W、1 060 n C、1.87×1011 cm-3和8.07 p F,气相放电可用电压控制电流源(VCCS)、电阻和可变电容来等效,而液体可用可变电阻等效,计算得到放电前其值为825?。
