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Diabetic nephropathy and inflammation 被引量:178
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作者 Montserrat B Duran-Salgado Alberto F Rubio-Guerra 《World Journal of Diabetes》 SCIE CAS 2014年第3期393-398,共6页
Diabetic nephropathy(DN) is the leading cause of end-stage renal failure worldwide. Besides, diabetic nephropathy is associated with cardiovascular disease, and increases mortality of diabetic patients. Several factor... Diabetic nephropathy(DN) is the leading cause of end-stage renal failure worldwide. Besides, diabetic nephropathy is associated with cardiovascular disease, and increases mortality of diabetic patients. Several factors are involved in the pathophysiology of DN, including metabolic and hemodynamic alterations, oxidative stress, and activation of the renin-angiotensin system. In recent years, new pathways involved in the development and progression of diabetic kidney disease have been elucidated; accumulated data have emphasized the critical role of inflammation in the pathogenesis of diabetic nephropathy. Expression of cell adhesion molecules, growth factors, chemokines and pro-inflammatory cytokines are increased in the renal tissues of diabetic patients, and serum and urinary levels of cytokines and cell adhesion molecules, correlated with albuminuria. In this paper we review the role of inflammation in the development of diabetic nephropathy, discussing some of the major inflammatory cytokines involved in the pathogenesis of diabetic nephropathy, including the role of adipokines, and take part in other mediators of inflammation, as adhesion molecules. 展开更多
关键词 DIABETIC NEPHROPATHY INFLAMMATION ALBUMINURIA Adhesion molecules CYTOKINES
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超重力反应沉淀法合成纳米材料及其应用 被引量:68
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作者 陈建峰 邹海魁 +2 位作者 刘润静 曾晓飞 沈志刚 《现代化工》 EI CAS CSCD 北大核心 2001年第9期9-12,共4页
纳米材料的合成与制备技术已成为全球的研究热点。介绍了一种独创性的纳米材料合成方法即超重力反应沉淀法。从成核动力学、传质、多相体系中分子或原子尺度上的混合机理等方面对该方法进行了理论阐述 ,依此为指导 ,成功地制备出粒度分... 纳米材料的合成与制备技术已成为全球的研究热点。介绍了一种独创性的纳米材料合成方法即超重力反应沉淀法。从成核动力学、传质、多相体系中分子或原子尺度上的混合机理等方面对该方法进行了理论阐述 ,依此为指导 ,成功地制备出粒度分布窄化的纳米粉体。介绍了目前合成的碳酸钙、氢氧化铝、碳酸钡。 展开更多
关键词 超重力反应沉淀法 纳米材料 合成 制备 应用
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Recent advances in gastric cancer early diagnosis 被引量:84
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作者 Laura Necula Lilia Matei +6 位作者 Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu 《World Journal of Gastroenterology》 SCIE CAS 2019年第17期2029-2044,共16页
Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the tr... Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. 展开更多
关键词 Biomarkers GASTRIC cancer Early diagnosis Genetic and EPIGENETIC alterations CIRCULATING molecules
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Long non-coding RNAs: From disease code to drug role 被引量:51
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作者 Yuanyuan Chen Zhaojun Li +1 位作者 Xiaoguang Chen Sen Zhang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第2期340-354,共15页
Enormous studies have corroborated that long non-codig RNAs(LncRNAs)extensively participate in crucial physiological processes such as metabolism and immunity,and are closely related to the occurrence and development ... Enormous studies have corroborated that long non-codig RNAs(LncRNAs)extensively participate in crucial physiological processes such as metabolism and immunity,and are closely related to the occurrence and development of tumors,cardiovascular diseases,nervous system disorders,nephropathy,and other diseases.The application of lncRNAs as biomarkers or intervention targets can provide new insights into the diagnosis and treatment of diseases.This paper has focused on the emerging research into lncRNAs as pharmacological targets and has reviewed the transition of IncRNAs from the role of disease coding to acting as drug candidates,including the current status and progress in preclinical research.Cutting-edge strategies for lncRNA modulation have been summarized,including the sources of LncRNA-related drugs,such as genetic technology and small-molecule compounds,and related delivery methods.The current progress of clinical trials of lncRNA-targeting drugs is also discussed.This information will form a latest updated reference for research and development of lncRNA-based drugs. 展开更多
关键词 LncRNAs Targeted drug Gene therapy Small molecules Delivery ASncmtRNA Translational medicine Clinical trials
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Pathogenic aspects of pulmonary complications in acute pancreatitis patients 被引量:47
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作者 Serge Chooklin 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2009年第2期186-192,共7页
BACKGROUND:Experimental and clinical observations show that proinflammatory cytokines and oxidative stress are involved in the development of local and particularly systemic complications in acute pancreatitis (AP) pa... BACKGROUND:Experimental and clinical observations show that proinflammatory cytokines and oxidative stress are involved in the development of local and particularly systemic complications in acute pancreatitis (AP) patients. There are often pulmonary complications in such patients. The mechanisms through which lung injury is induced in AP are not fully clear. METHODS:In order to assess the role of activated neutrophils, pro- and anti-inflammatory cytokines and adhesion molecules at the onset and development of respiratory complications and respiratory failure, we measured the serum levels of pro-inflammatory (IL-1β, IL-6, IL-8, IL-18, TNF-α) and anti-inflammatory (IL-1ra, IL-10) cytokines in 51 AP patients who had been diagnosed with pancreatitis-associated lung injury with and without the development of organ dysfunction. RESULTS:When admitted to the hospital, severe AP patients had increased concentrations of IL-1β, IL-6, IL-8, IL-18, and TNF-α. The concentration of IL-18 alone was considerably increased in the patients who later developed respiratory failure. The onset of acute respiratory distress syndrome in the AP patients was accompanied by an increase in the level of anti-inflammatory cytokines, especially IL-10. It was noted that in severe lung injury, myeloperoxidase activity in the blood increased significantly, but still reflected the processes taking place in the lung parenchyma. Increase in the concentrations of adhesion molecules preceded the development of pulmonary infiltration with respiratory failure symptoms, which provoked endothelial dysfunction and determined the capillary surface permeability for neutrophils and monocytes.CONCLUSIONS:In the pathogenesis of respiratory complications in AP cytokines, chemokines and adhesion molecules, in particular IL-1β, IL-6, IL-8, IL-18, TNF-α, ICAM-1, and E-selectin play major roles. At IL-18 concentrations >650 pg/ml, AP patients are likely to develop pulmonary dysfunction (sensitivity 58%, specificity 100%, LR-positive >58) which allows us to use 展开更多
关键词 acute pancreatitis pulmonary complications CYTOKINES adhesion molecules
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Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery 被引量:27
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作者 Jing-Yan Han Yoshinori Horie +17 位作者 Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第26期3581-3591,共11页
AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope ... AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. 展开更多
关键词 Compound Danshen Mesenteric microci-rculation Oxygen-free radical Adhesion molecules LIPOPOLYSACCHARIDE
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Boron in Plants: Deficiency and Toxicity 被引量:26
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作者 Juan J. Camacho-Cristóbal Jesús Rexach Agustín Gonzlez-Fontes 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2008年第10期1247-1255,共9页
Boron (B) is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is u... Boron (B) is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the ceil wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants. 展开更多
关键词 boron-binding molecules boron transporter cell wall-related genes gene expression nitrogen metabolism
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染料敏化太阳电池中固体电解质研究进展 被引量:14
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作者 叶宏伟 陈红征 汪茫 《太阳能学报》 EI CAS CSCD 北大核心 2002年第5期543-549,共7页
综述了染料敏化太阳能电池中固体电解质的发展。总结了 3种主要的固体电解质 ,即P 型半导体、导电聚合物和空穴传输有机分子的制备、性能和机理研究。
关键词 染料敏化太阳电池 固体电解质 P-型半导体 导电聚合物 空穴传输有机分子
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关于中学生的原子、分子心智模型的研究 被引量:11
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作者 魏冰 贾玉江 +1 位作者 潘海鸿 钱玲 《化学教育》 CAS 2001年第3期6-9,13,共5页
学生对于科学概念的认识被称为学生的心智模型。本研究探讨了学生关于原子、分子2个概念的心智模型。研究采用半结构的访谈法 ,访谈对象是初三、高一和大学一年级的学生。文章从 2个方面对研究结果进行了分析 :学生关于原子模型的认识... 学生对于科学概念的认识被称为学生的心智模型。本研究探讨了学生关于原子、分子2个概念的心智模型。研究采用半结构的访谈法 ,访谈对象是初三、高一和大学一年级的学生。文章从 2个方面对研究结果进行了分析 :学生关于原子模型的认识、学生对于原子、分子的描述。文章最后对研究结果进行了讨论。 展开更多
关键词 中学生 原子模型 分子 科学概念 初三 文章 高一 大学一年级 描述 访谈
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Anti-diabetic activity of quercetin extracted from Phyllanthus emblica L.fruit: In silico and in vivo approaches 被引量:20
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作者 Prabhu Srinivasan S.Vijayakumar +1 位作者 Swaminathan Kothandaraman Manogar Palani 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2018年第2期109-118,共10页
In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated r... In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies. 展开更多
关键词 Bioactive molecules GLYCOGEN PHOSPHORYLASE molecular docking PHYLLANTHUS emblica QUERCETIN ALBINO WISTER male rats
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日本血吸虫铁蛋白基因的筛选、克隆与表达 被引量:18
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作者 易新元 曾宪芳 +2 位作者 周金春 蔡春 舒新华 《湖南医科大学学报》 CSCD 1998年第5期425-428,共4页
采用Sj未成熟虫卵抗原超免疫兔血清(RASjIEA)对Sj成虫cDNA文库进行筛选,并对可能具有抗日本血吸虫生殖/卵胚发育潜能的抗原分子进行克隆、表达。常规法免疫筛选Sj成虫文库,获得单个阳性克隆,PCR扩增后琼脂糖... 采用Sj未成熟虫卵抗原超免疫兔血清(RASjIEA)对Sj成虫cDNA文库进行筛选,并对可能具有抗日本血吸虫生殖/卵胚发育潜能的抗原分子进行克隆、表达。常规法免疫筛选Sj成虫文库,获得单个阳性克隆,PCR扩增后琼脂糖电泳测定基因大小,DNA测序,基因库搜索,找出同源基因。共鉴定出6个不同的基因克隆。选择其中的铁蛋白(SjFer)基因亚克隆于pGMC载体。重组蛋白以GMCSF(粒细胞巨噬细胞集落刺激因子)-SjFer融合蛋白的形式在细菌中高效表达。表达产物仅溶于8M尿素溶液中,分子量为40kD。 展开更多
关键词 日本血吸虫 铁蛋白基因 克隆 基因表达
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Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance 被引量:18
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作者 Kamran Ghaffarzadehgan Mostafa Jafarzadeh +6 位作者 Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第41期6376-6381,共6页
AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences betwee... AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. 展开更多
关键词 Gastric cancer Cluster of differentiation 44 Survival rateImmunohistochemistry Cell adhesion molecules
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Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis 被引量:17
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作者 Joshua Ka-Shun Ko Flora Ying-Lee Lam Andrew Pok-Lap Cheung 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第37期5787-5794,共8页
AIM: To investigate the protective effects of Astragalus membranaceus(Am) against hapten-induced colitis in male Sprague-Dawley rats as well as its underlying mechanism.METHODS: Experimental colitis was induced in rat... AIM: To investigate the protective effects of Astragalus membranaceus(Am) against hapten-induced colitis in male Sprague-Dawley rats as well as its underlying mechanism.METHODS: Experimental colitis was induced in rats by enema administration of 2,4-dinitrobenzene sulfonic acid (DNBS). Rats were either pretreated with Am extract (2 or 4 g/kg, p.o. once daily) starting from 10 d before DNBS enema, or received Am post-treatment (2 or 4 g/kg, p.o.twice daily) on the three consecutive days following DNBS administration. Colonic lesion area and histological damage were determined, while the activities of myeloperoxidase (MPO) and xanthine oxidase, as well as reduced glutathione (GSH) content were measured in the excised colonic tissues. Besides, protein expression of inducible nitrite oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1) and P-selectin was also detected by Western blot analysis.RESULTS: Our findings had shown that both macroscopic lesion area and histological colonic damage induced by DNBS were significantly reduced by both Am pre- and post-treatments. These were accompanied by attenuation of the elevated colonic MPO activity and downregulation of the iNOS, P-selectin, and ICAM-1 protein expression.Besides, deprivation of colonic GSH level under colitis condition was also preserved.CONCLUSION: These results demonstrate that Am possesses both preventive and therapeutic potential in experimental colitis. The anti-inflammatory actions involve anti-oxidation along with inhibition of adhesion molecule synthesis in the colonic tissues. 展开更多
关键词 IBD Astragalus membranaceus Reactiveoxygen metabolites Adhesion molecules
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基于介质体内陷阱参数与松弛过程的XLPE电缆绝缘热老化行为分析 被引量:19
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作者 申作家 罗智奕 +5 位作者 詹威鹏 陈腾彪 褚学来 余盈荧 欧阳本红 李建英 《中国电机工程学报》 EI CSCD 北大核心 2016年第19期5382-5388,5421,共8页
该文通过热刺激电流法(thermally stimulated depolarization current,TSDC)研究了热老化对XLPE电缆绝缘陷阱参数的影响。TSDC结果表明,XLPE绝缘在-70、-30、75、95及105℃附近共出现了5个松弛峰。-70和-30℃附近的两个松弛峰在整个热... 该文通过热刺激电流法(thermally stimulated depolarization current,TSDC)研究了热老化对XLPE电缆绝缘陷阱参数的影响。TSDC结果表明,XLPE绝缘在-70、-30、75、95及105℃附近共出现了5个松弛峰。-70和-30℃附近的两个松弛峰在整个热老化过程中活化能保持不变,可认为是XLPE的本征松弛过程,分别对应无定形区链段运动和羰基转向极化,其陷阱电荷量在重结晶阶段基本不变,在热氧老化阶段快速增加。75℃附近的松弛峰对应XLPE晶区与非晶区界面处陷阱电荷的释放。在重结晶阶段,该峰的活化能增大,陷阱电荷量保持不变,在热氧老化阶段该峰的活化能趋于饱和,陷阱电荷量增大。95和105℃附近的两个松弛峰分别对应晶区分子链段的运动和起始熔融过程,总陷阱电荷量在重结晶阶段增加,在热氧老化阶段减少。 展开更多
关键词 交联聚乙烯 热老化 热刺激去极化电流 陷阱参数 活化能 极化
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Relationship between cell adhesion molecules expression and the biological behavior of gastric carcinoma 被引量:17
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作者 Yong-Quan Chu Zai-Yuan Ye +2 位作者 Hou-Quan Tao Yuan-Yu Wang Zhong-Sheng Zhao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第13期1990-1996,共7页
AIM: To evaluate the relationship between the expression of cell adhesion molecules (CAMs) and the biological behavior of gastric carcinoma. METHODS: Expression of syndecan-1, E-cadherin and integrin β3 were evaluate... AIM: To evaluate the relationship between the expression of cell adhesion molecules (CAMs) and the biological behavior of gastric carcinoma. METHODS: Expression of syndecan-1, E-cadherin and integrin β3 were evaluated by immunohistochemical study in a total of 118 gastric carcinomas and 20 non- tumor gastric mucosas. RESULTS: The expressions of syndecan-1 and E-cadherin were significantly lower in gastric carcinoma compared to non-tumor gastric mucosa, and the low expression rates were positively correlated to the tumor invasion depth, vessel invasion, lymph node metastasis and distant metastasis (P < 0.01 in all cases). However, the expression of integrin β3 was significantly higher in gastric carcinoma compared to non-tumor gastric mucosa, and the high expression rates were positively correlated to the tumor invasion depth, vessel invasion, lymph node metastasis and distant metastasis (P < 0.01 in all cases). In addition, the three protein expressions were correlated to the tumor growth pattern (P < 0.01, P < 0.01, and P < 0.05 respectively), but not correlated to tumor differentiation (P > 0.05, P > 0.05 and P > 0.05 respectively). Positive correlation was observed between the expressions of syndecan-1 and E-cadherin, but they which were negatively correlated to the expression of integrin β3 (P < 0.01 in all cases). Univariate analysis demonstrated that the mean survival time and 5-year survival rate were lower in the cases with low expressions of syndecan-1 and E-cadherin and high expression of integrin β3 (P < 0.01, in all cases). COX multivariate analysis showed that the expression level of syndecan-1 could be an independent prognostic index of gastric carcinoma (P < 0.01), whereas E-cadherin and integrin β3 could not be independent indexes (P > 0.05, P > 0.05 respectively). CONCLUSION: The low expression of syndecan-1 and E-cadherin and the high expression of integrin β3 are significantly correlated with the invasion and metastasis of gastric carcinoma, and they are highly correlated with each other. 展开更多
关键词 Cell adhesion molecules Gastric Carcinoma Invasion Metastasis PROGNOSIS
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Inflammatory mechanism in ischemic neuronal injury 被引量:15
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作者 Ya-Dan WEN Hui-Ling ZHANG Zheng-Hong QIN 《Neuroscience Bulletin》 SCIE CAS CSCD 2006年第3期171-182,共12页
Inflammation has been implicated as a secondary mechanism underlying neuronal injury induced by ischemia. A variety of experimental models, including thromboembolic stroke, focal and global ischemia, have been used to... Inflammation has been implicated as a secondary mechanism underlying neuronal injury induced by ischemia. A variety of experimental models, including thromboembolic stroke, focal and global ischemia, have been used to evaluate contributions of inflammation to neuronal damage. The vasculature endothelium promotes inflammation through upregulation of adhesion molecules such as intercellular adhesion molecule (ICAM), E-selectin, and P-selectin that bind to circulating leukocytes and facilitate migration of leukocytes into the central nervous system (CNS). Once being in the CNS, leukocytes produce cytotoxic molecules that promote cell death. The response of macrophages and microglia to injury may either be beneficial by scavenging necrotic debris or be detrimental by facilitating cell death of neurons that would otherwise recover. While many studies have tested these hypotheses, the significance of inflammation in stroke models is inconclusive. This review summarizes data regarding roles of cell adhesion molecules, astrocytes, microglia and leukocytes in stroke. 展开更多
关键词 ischemic stroke INFLAMMATION cell adhesion molecules ASTROCYTES MICROGLIA NF-KB leukocytes
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Local signals in stem cell-based bone marrow regeneration 被引量:17
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作者 Wei Han Yan Yu Xin Yuan Liu 《Cell Research》 SCIE CAS CSCD 2006年第2期189-195,共7页
The cellular basis of bone marrow (BM) tissue development and regeneration is mediated through hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Local interplays between hematopoietic cells and ... The cellular basis of bone marrow (BM) tissue development and regeneration is mediated through hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Local interplays between hematopoietic cells and BM stromal cells (BMSCs) determine the reconstitution of hematopoiesis after myelosuppression. Here we review the BM local signals in control of BM regeneration after insults. Hematopoietic growth factors (HGFs) and cytokines produced by BMSCs are primary factors in regulation ofBM hematopoiesis. Morphogens which are critical to early embryo development in multiple species have been added to the family of HSCs regulators, including families of Wnt proteins, Notch ligands, BMPs, and Hedgehogs. Global gene expression analysis of HSCs and BMSCs has begun to reveal signature groups of genes for both cell types. More importantly, analysis of global gene expression coupled with biochemical and biological studies of local signals during BM regeneration have strongly suggested that HGFs and cytokines may not be the primary local regulators for BM recovery, rather chemokines (SDF- 1, FGF-4) and angiogenic growth factors (VEGF-A, Ang- 1) play instructive roles in BM reconstitution after myelosuppression. A new direction of management of BM toxicity is emerging from the identification of BM regenerative regulators. 展开更多
关键词 bone marrow REGENERATION hematopoietic stem cells mesenchymal stem cells signaling molecules MYELOSUPPRESSION
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The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator 被引量:15
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作者 Ling Li Mei Dong Xiao-Guang Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第4期448-455,共8页
Objective: This review focuses on the current knowledge on the implication and significance of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate.Data Sources: The data used in this review w... Objective: This review focuses on the current knowledge on the implication and significance of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate.Data Sources: The data used in this review were obtained from PubMed up to October 2015.Terms of β2M, immune response, and infection were used in the search.Study Selections: Articles related to β2M were retrieved and reviewed.Articles focusing on the characteristic and function of β2M were selected.The exclusion criteria of articles were that the studies on β2M-related molecules.Results: β2M is critical for the immune surveillance and modulation in vertebrate animals.The dysregulation of β2M is associated with multiple diseases, including endogenous and infectious diseases.β2M could directly participate in the development of cancer cells, and the level of β2M is deemed as a prognostic marker for several malignancies.It also involves in forming major histocompatibility complex (MHC class Ⅰ or MHC Ⅰ) or like heterodimers, covering from antigen presentation to immune homeostasis.Conclusions: Based on the characteristic of β2M, it or its signaling pathway has been targeted as biomedical or therapeutic tools.Moreover, β2M is highly conserved among different species, and overall structures are virtually identical, implying the versatility of β2M on applications. 展开更多
关键词 Beta 2 Microglobulin Immune Dysregulation Major Histocompatibility Complex Class I or Like molecules
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Role of adhesion molecules and dendritic cells in rat hepatic/renal ischemia-reperfusion injury and anti-adhesive intervention with anti-P-selectin lectin-EGF domain monoclonal antibody 被引量:16
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作者 TongZhou Gui-ZhiSun +5 位作者 Ming-JunZhang Jin-LianChen Dong-QingZhang Qing-ShenHu Yu-YingChen NanChen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第7期1005-1010,共6页
AIM: To investigate the role of P-selectin, intercellular adhesion molecule-1 (ICAM-1) and dendritic cells (DCs)in liver/kidney of rats with hepatic/renal ischemiareperfusion injury and the preventive effect of anti-P... AIM: To investigate the role of P-selectin, intercellular adhesion molecule-1 (ICAM-1) and dendritic cells (DCs)in liver/kidney of rats with hepatic/renal ischemiareperfusion injury and the preventive effect of anti-Pselectin lectin-EGF domain monoclonal antibody (anti-PsLEGFmAb) on the injury.METHODS: Rat models of hepatic and renal ischemiareperfusion were established. The rats were then divided into two groups, one group treated with anti-PsL-EGFmAb(n = 20) and control treated with saline (n = 20). Both groups were subdivided into four groups according to reperfusion time (1, 3, 6 and 24 h). The sham-operated group (n = 5) served as a control group. DCs were observed by the microscopic image method, while P-selectin and ICAM-1 were analyzed by immunohistochemistry.RESULTS: P-selectin increased significantly in hepatic sinusoidal endothelial cells and renal tubular epithelial cells 1 h after ischemia-reperfusion, and the expression of ICAM-1 was up-regulated in hepatic sinusoid and renal vessels after 6 h. CD1a+CD80+DCs gradually increased in hepatic sinusoidal endothelium and renal tubules and interstitium 1 h after ischemia-reperfusion, and there was the most number of DCs in 24-h group. The localization of DCs was associated with rat hepatic/renal function.These changes became less significant in rats treated with anti-PsL-EGFmAb.CONCLUSION: DCs play an important role in immune pathogenesis of hepatic/renal ischemia-reperfusion injury.Anti-PsL-EGFmAb may regulate and inhibit local DC immigration and accumulation in liver/kidney. 展开更多
关键词 Adhesion molecules Dendritic cells Hepatic/ renal ischemia-reperfusion injury Anti-P-selectin lectinEGF domain monoclonal antibody
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大菱鲆荧光假单胞菌的群体感应现象及不同碳源培养下的腐败特性研究 被引量:15
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作者 崔方超 李婷婷 +2 位作者 刘明爽 马燕 励建荣 《现代食品科技》 EI CAS 北大核心 2015年第12期49-55,共7页
本文以大菱鲆分离的荧光假单胞菌作为研究对象,紫色杆菌CVO26平行划线法检测信号分子。不同碳源(葡萄糖、蔗糖、果糖、木糖、乳糖、麦芽糖)的AB培养基培养并检测其生物被膜、嗜铁素和胞外蛋白酶的产生量,同时添加外源的信号分子标准品,... 本文以大菱鲆分离的荧光假单胞菌作为研究对象,紫色杆菌CVO26平行划线法检测信号分子。不同碳源(葡萄糖、蔗糖、果糖、木糖、乳糖、麦芽糖)的AB培养基培养并检测其生物被膜、嗜铁素和胞外蛋白酶的产生量,同时添加外源的信号分子标准品,研究AHLs与腐败因子之间的相关性。研究表明:大菱鲆分离的荧光假单胞菌能够发生群体感应现象,经不同碳源培养,其腐败因子产生情况有明显差异,碳源的添加对生物被膜的产生有促进作用,对胞外蛋白酶的产生没有显著影响;以葡萄糖、麦芽糖为碳源,生物被膜的产生量较高;以蔗糖和乳糖为碳源,嗜铁素的产量较高。添加外源信号分子标准品,生物被膜、嗜铁素和胞外蛋白酶的产生量有显著提高。因此,生物被膜、嗜铁素和胞外蛋白酶的产生与AHLs有关,群体感应现象可调控腐败特性的表达,并在水产品腐败过程中发挥作用。 展开更多
关键词 荧光假单胞菌 群体感应信号分子 生物被膜 嗜铁素 胞外蛋白酶
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