目的对“临床药物不良事件(adverse drug event,ADE)主动监测与智能评估警示系统-Ⅱ”的心律失常自动监测模块进行功能开发与优化,持续完善性能,提升监测效率,探索模块优化方式。方法拓展优化模块功能,增加模块自定义配置内容,并确定最...目的对“临床药物不良事件(adverse drug event,ADE)主动监测与智能评估警示系统-Ⅱ”的心律失常自动监测模块进行功能开发与优化,持续完善性能,提升监测效率,探索模块优化方式。方法拓展优化模块功能,增加模块自定义配置内容,并确定最优设置条件;对比优化后测试数据与前期大样本用药人群中药源性心律失常自动监测评价研究结果,验证模块优化程度和准确性。结果根据监测人群特征优化后的新模块,增加了“强制医嘱关键词”功能,并确定纳入6个心电图检查相关的医嘱关键词、且出现频率不少于2次为模块优化最佳配置条件;结合前期自动监测评价研究结果,开展全药和2种单药条件下系统功能验证和比较。在真阳性病例零丢失的同时,系统报警的病例数较模块优化前分别下降了30.75%、80.13%和90.82%,阳性预测值得到了显著提升。结论经过功能拓展与优化完善的心律失常自动监测模块显著降低了病例评价人工成本,同时保持监测结果准确度不变;新模块能够更好地适应自动监测不同模式需求且运行稳定,更具普适性和灵活性,为自动监测模块研发提供了新的思维途径。展开更多
Leymus chinensis （Trin.） Tzveh is a rhizomatous perennial herbage of Gramineae. Reproduction is mainly by vegetative reproduction. Tillering nodes and rhizomes of L. chinensis serve as organs for both vegetative rep...Leymus chinensis （Trin.） Tzveh is a rhizomatous perennial herbage of Gramineae. Reproduction is mainly by vegetative reproduction. Tillering nodes and rhizomes of L. chinensis serve as organs for both vegetative reproduction and nutrient storage. Water-soluble carbohydrate （WSC） contents were measured in tillering nodes, nodes and Internodes of rhizomes of different age classes of L. chinensis populations at three development stages, namely the dough ripe stage, the vegetative growth stage after full ripeness, and the withering stage, in two habitats： sandy soil and saline-alkaline soil. The results showed that WSC content in tillering nodes of the three age classes of L. chinensis were all markedly decreased with increasing age in both sandy soil and saline-alkaline solh A similar trend of changes In WSC contents was observed in the nodes and internodes of rhizomes in different age classes In both habitats. The highest WSC contents were in 2-age-class nodes and internodes of rhizomes, followed by those In the 1 age class, with the lowest WSC contents found in 3-age-class nodes and internodes of rhizomes at the dough ripe and vegetative growth stages after full ripening. In turn, WSC contents decreased with Increasing age at the withering stage in both habitats. The WSC content in each age class of internode was higher than that in the node of rhizome at three development stages in both habitats.展开更多
文摘目的对“临床药物不良事件(adverse drug event,ADE)主动监测与智能评估警示系统-Ⅱ”的心律失常自动监测模块进行功能开发与优化,持续完善性能,提升监测效率,探索模块优化方式。方法拓展优化模块功能,增加模块自定义配置内容,并确定最优设置条件;对比优化后测试数据与前期大样本用药人群中药源性心律失常自动监测评价研究结果,验证模块优化程度和准确性。结果根据监测人群特征优化后的新模块,增加了“强制医嘱关键词”功能,并确定纳入6个心电图检查相关的医嘱关键词、且出现频率不少于2次为模块优化最佳配置条件;结合前期自动监测评价研究结果,开展全药和2种单药条件下系统功能验证和比较。在真阳性病例零丢失的同时,系统报警的病例数较模块优化前分别下降了30.75%、80.13%和90.82%,阳性预测值得到了显著提升。结论经过功能拓展与优化完善的心律失常自动监测模块显著降低了病例评价人工成本,同时保持监测结果准确度不变;新模块能够更好地适应自动监测不同模式需求且运行稳定,更具普适性和灵活性,为自动监测模块研发提供了新的思维途径。
基金Supported by the National Natural Science Foundation of China （30270260, 30470272, and 30070137）.The authors thank Dr Shang-Yi Tian and Yun-Yang Zhao for assistance with the experiments. The authors are also grateful to Dr Rui Guo and Dr Li Wang for their comments on the manuscript.
文摘Leymus chinensis （Trin.） Tzveh is a rhizomatous perennial herbage of Gramineae. Reproduction is mainly by vegetative reproduction. Tillering nodes and rhizomes of L. chinensis serve as organs for both vegetative reproduction and nutrient storage. Water-soluble carbohydrate （WSC） contents were measured in tillering nodes, nodes and Internodes of rhizomes of different age classes of L. chinensis populations at three development stages, namely the dough ripe stage, the vegetative growth stage after full ripeness, and the withering stage, in two habitats： sandy soil and saline-alkaline soil. The results showed that WSC content in tillering nodes of the three age classes of L. chinensis were all markedly decreased with increasing age in both sandy soil and saline-alkaline solh A similar trend of changes In WSC contents was observed in the nodes and internodes of rhizomes in different age classes In both habitats. The highest WSC contents were in 2-age-class nodes and internodes of rhizomes, followed by those In the 1 age class, with the lowest WSC contents found in 3-age-class nodes and internodes of rhizomes at the dough ripe and vegetative growth stages after full ripening. In turn, WSC contents decreased with Increasing age at the withering stage in both habitats. The WSC content in each age class of internode was higher than that in the node of rhizome at three development stages in both habitats.
