Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility...Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility for a number of neurological conditions,Recently,there was little understanding of the the efficacy ofrYMS on Schizophrenia（SZ） and the change of ERP between before and after rTMS treatment.The objective of this study was to investigate the characteristics of N400,mismatch negativity （MMN）,and P300 before and after treatment with rTMS in SZ.Methods：One hundred and twenty-seven SZ patients hospitalized in Shanghai Mental Health Center from March 2015 to July 2017,divided into two groups （85 patients were recruited as rTMS group and 42 were recruited as sham rTMS [ShrTMS] group） and 76 normal controls （NCs） who were the staff and refresher staff in our hospital were recruited at the same time.A Chinese-made rTMS and a Runjie W J-1 ERPs instrument were used in the present experiment.N400 was elicited by congruent and noncongruent Chinese idioms.After rTMS treatment,N400,P300,and MMN characteristics were compared with those before treatment and NC group.Results：Compared with NC,the SZ patients exhibited delays in N400,P300,and MMN latency and decreased N400,P300,and MMN amplitudes in their frontal area （P 〈 0.05）.After 25 rTMS treatments,N400 amplitudes in the frontal area （elicited by idioms with same phonic and different shape and meaning and with different phonic,shape,and meaning） were increased in the SZ patients （P 〈 0.05）.However,there was no significant change in N400 before and after treatment with ShrTMS in SZ patients （P 〉 0.05）.Amplitudes for MMN and target P300 also increased in SZ patients after rTMS treatment （P 〈 0.05）.Conclusions：Based on our preliminary findings,we believe that the combined usage of N400,MMN,and P300 could be a valuable index and an electrophysiological reference in evaluating the effects ofrTMS treatment in SZ pat展开更多
脑力负荷是影响飞行安全的重要因素之一,对飞行员脑力负荷进行客观测量,对于飞机座舱显示界面脑力任务的工效评价与优化设计具有重要意义.基于ERP(Eveat Related Potential)技术,选取失匹配负波(MMN,Mismatch Negativity)和P3a成分为指...脑力负荷是影响飞行安全的重要因素之一,对飞行员脑力负荷进行客观测量,对于飞机座舱显示界面脑力任务的工效评价与优化设计具有重要意义.基于ERP(Eveat Related Potential)技术,选取失匹配负波(MMN,Mismatch Negativity)和P3a成分为指标,采用三刺激"oddball"模式,在飞行模拟任务条件下开展了三级脑力负荷的测量与评价研究.实验结果表明,MMN峰值和P3a峰值对脑力负荷变化敏感,随着脑力负荷的增加,MMN峰值显著增加,而P3a峰值显著降低,反应了被试者对异常信息的自动加工能力的提高以及朝向注意能力的减弱.与新异刺激相比,由偏差刺激所诱发的MMN与P3a成分对于与飞行任务相关的脑力负荷具有更好的敏感性,将可用于进一步的脑力负荷分级评价.展开更多
In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness （DOCs）. In this paper, an oddball paradigm with two types of fr...In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness （DOCs）. In this paper, an oddball paradigm with two types of frequencydeviant stimulus （standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz） was applied to elicit mismatch negativity （MMN） in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale- Revised （CRS-R）. The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions （small and large deviant stimuli） and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location （frontocentral area） at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.展开更多
目的探讨功能性构音障碍(FAD)患儿中枢听觉加工特点及儿童FAD的可能病因。方法选择符合FAD诊断标准的27例患儿作为病例组,年龄匹配的正常儿童50例作为对照组,比较病例组与对照组个人语言发育史阳性病史率,检测二组儿童事件相关电位,比...目的探讨功能性构音障碍(FAD)患儿中枢听觉加工特点及儿童FAD的可能病因。方法选择符合FAD诊断标准的27例患儿作为病例组,年龄匹配的正常儿童50例作为对照组,比较病例组与对照组个人语言发育史阳性病史率,检测二组儿童事件相关电位,比较其失匹配负波(MMN)形态学、潜伏期及峰振幅。结果病例组个人语言发育史中阳性病史比例显著高于对照组,差异有统计学意义(70%vs 8%,P<0.01);其MMN峰潜伏期较对照组显著延长,差异有统计学意义(209±31 ms 175±32 ms,P<0.01);其峰振幅低于对照组,但差异无统计学意义(P>0.05)。结论中枢听觉加工时间延长可能是儿童FAD的发病原因之一。展开更多
In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as...In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.展开更多
基金This study was supported by a grant from the National Natural Science Foundation of China （No. 81471357）.
文摘Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility for a number of neurological conditions,Recently,there was little understanding of the the efficacy ofrYMS on Schizophrenia（SZ） and the change of ERP between before and after rTMS treatment.The objective of this study was to investigate the characteristics of N400,mismatch negativity （MMN）,and P300 before and after treatment with rTMS in SZ.Methods：One hundred and twenty-seven SZ patients hospitalized in Shanghai Mental Health Center from March 2015 to July 2017,divided into two groups （85 patients were recruited as rTMS group and 42 were recruited as sham rTMS [ShrTMS] group） and 76 normal controls （NCs） who were the staff and refresher staff in our hospital were recruited at the same time.A Chinese-made rTMS and a Runjie W J-1 ERPs instrument were used in the present experiment.N400 was elicited by congruent and noncongruent Chinese idioms.After rTMS treatment,N400,P300,and MMN characteristics were compared with those before treatment and NC group.Results：Compared with NC,the SZ patients exhibited delays in N400,P300,and MMN latency and decreased N400,P300,and MMN amplitudes in their frontal area （P 〈 0.05）.After 25 rTMS treatments,N400 amplitudes in the frontal area （elicited by idioms with same phonic and different shape and meaning and with different phonic,shape,and meaning） were increased in the SZ patients （P 〈 0.05）.However,there was no significant change in N400 before and after treatment with ShrTMS in SZ patients （P 〉 0.05）.Amplitudes for MMN and target P300 also increased in SZ patients after rTMS treatment （P 〈 0.05）.Conclusions：Based on our preliminary findings,we believe that the combined usage of N400,MMN,and P300 could be a valuable index and an electrophysiological reference in evaluating the effects ofrTMS treatment in SZ pat
文摘脑力负荷是影响飞行安全的重要因素之一,对飞行员脑力负荷进行客观测量,对于飞机座舱显示界面脑力任务的工效评价与优化设计具有重要意义.基于ERP(Eveat Related Potential)技术,选取失匹配负波(MMN,Mismatch Negativity)和P3a成分为指标,采用三刺激"oddball"模式,在飞行模拟任务条件下开展了三级脑力负荷的测量与评价研究.实验结果表明,MMN峰值和P3a峰值对脑力负荷变化敏感,随着脑力负荷的增加,MMN峰值显著增加,而P3a峰值显著降低,反应了被试者对异常信息的自动加工能力的提高以及朝向注意能力的减弱.与新异刺激相比,由偏差刺激所诱发的MMN与P3a成分对于与飞行任务相关的脑力负荷具有更好的敏感性,将可用于进一步的脑力负荷分级评价.
基金supported by the National Natural Science Foundation of China (81471742, 91748105)Fundamental Research Funds for the Central Universities [DUT16JJ(G)03] in Dalian University of Technology, China
文摘In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness （DOCs）. In this paper, an oddball paradigm with two types of frequencydeviant stimulus （standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz） was applied to elicit mismatch negativity （MMN） in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale- Revised （CRS-R）. The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions （small and large deviant stimuli） and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location （frontocentral area） at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.
文摘目的探讨功能性构音障碍(FAD)患儿中枢听觉加工特点及儿童FAD的可能病因。方法选择符合FAD诊断标准的27例患儿作为病例组,年龄匹配的正常儿童50例作为对照组,比较病例组与对照组个人语言发育史阳性病史率,检测二组儿童事件相关电位,比较其失匹配负波(MMN)形态学、潜伏期及峰振幅。结果病例组个人语言发育史中阳性病史比例显著高于对照组,差异有统计学意义(70%vs 8%,P<0.01);其MMN峰潜伏期较对照组显著延长,差异有统计学意义(209±31 ms 175±32 ms,P<0.01);其峰振幅低于对照组,但差异无统计学意义(P>0.05)。结论中枢听觉加工时间延长可能是儿童FAD的发病原因之一。
基金supported by the National Natural Science Foundation of China,No. 30973309
文摘In this experiment, 97 patients with obstructive sleep apnea hypopnea syndrome were divided into three groups （mild, moderate, severe） according to minimum oxygen saturation, and 35 healthy subjects were examined as controls. Cognitive function was determined using the mismatch negativity paradigm and the Montreal Cognitive Assessment. The results revealed that as the disease worsened, the mismatch negativity latency was gradually extended, and the amplitude gradually declined in patients with obstructive sleep apnea hypopnea syndrome. Importantly, mismatch negativity latency in severe patients with a persistent time of minimum oxygen saturation 〈 60 seconds was significantly shorter than that with a persistent time of minimum oxygen saturation 〉 60 seconds. Correlation analysis revealed a negative correlation between minimum oxygen saturation latency and Montreal Cognitive Assessment scores. These findings indicate that intermittent night-time hypoxemia affects mismatch negativity waveforms and Montrea Cognitive Assessment scores. As indicators for detecting the cognitive functional status of obstructive sleep apnea hypopnea syndrome patients, the sensitivity of mismatch negativity is 82.93%, the specificity is 73.33%, the accuracy rate is 81.52%, the positive predictive value is 85.00%, the negative predictive value is 70.21%, the positive likelihood ratio is 3, and the negative likelihood ratio is 0.23. These results indicate that mismatch negativity can be used as an effective tool for diagnosis of cognitive dysfunction in obstructive sleep apnea hypopnea syndrome patients.
