目的脑白质疏松症(leukoaraiosis,LA)与认知功能障碍有关,不同严重程度的LA患者其认知功能具体受何种损害还有待进一步研究。文中通过分析不同严重程度LA患者的认知功能,以期为早期认知功能障碍提供一定的防治依据。方法测定65例LA患者...目的脑白质疏松症(leukoaraiosis,LA)与认知功能障碍有关,不同严重程度的LA患者其认知功能具体受何种损害还有待进一步研究。文中通过分析不同严重程度LA患者的认知功能,以期为早期认知功能障碍提供一定的防治依据。方法测定65例LA患者与37例正常对照人员的简易精神状态量表(mini-mental state examination,MMSE)水平,分析不同程度LA与认知功能的相关性。结果 LA组患者MMSE评分显著低于正常对照组。Ⅳ型LA患者计算力、即刻回忆能力、延迟回忆能力、书写能力及视空间与执行能力均显著低于对照组(P<0.05),且与Ⅰ型相比具有显著统计学意义(P<0.05)。结论 LA患者认知功能下降,随着LA程度的加重,认知功能下降明显,主要导致记忆、计算、书写、视空间及执行功能的障碍。展开更多
OBJECTIVE： To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL： We retrieved publications from Cochrane Library （2004 to July 2011...OBJECTIVE： To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL： We retrieved publications from Cochrane Library （2004 to July 2011）, PubMed （1966 to July 2011）, the Chinese Science and Technique Journals Database （1977 to July 2011）, the China National Knowledge Infrastructure （1979 to July 2011）, Google Scholar （July 2011）, and the Chinese Biomedical Database （1977 to July 2011） using the key words ＂Chinese medicine OR Chinese herbal medicine＂ and ＂vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia＂. SELECTION CRITERIA： Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et I＇Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers＇ Handbook 5.0. MAIN OUTCOME MEASURES： Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS： We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants （1 605 patients took Chinese medicine decoctions （treatment group）; 1 263 patients took western medicine or placebo）. The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention （relative risk （RR） 展开更多
文摘目的脑白质疏松症(leukoaraiosis,LA)与认知功能障碍有关,不同严重程度的LA患者其认知功能具体受何种损害还有待进一步研究。文中通过分析不同严重程度LA患者的认知功能,以期为早期认知功能障碍提供一定的防治依据。方法测定65例LA患者与37例正常对照人员的简易精神状态量表(mini-mental state examination,MMSE)水平,分析不同程度LA与认知功能的相关性。结果 LA组患者MMSE评分显著低于正常对照组。Ⅳ型LA患者计算力、即刻回忆能力、延迟回忆能力、书写能力及视空间与执行能力均显著低于对照组(P<0.05),且与Ⅰ型相比具有显著统计学意义(P<0.05)。结论 LA患者认知功能下降,随着LA程度的加重,认知功能下降明显,主要导致记忆、计算、书写、视空间及执行功能的障碍。
基金supported by a Special Funding Project for the Chinese National Outstanding Ph.D.Thesis Author,No.201082the First Grade of China Postdoctoral Science Foundation,No.20110490080the National Natural Science Foundation of China,No.81202653
文摘OBJECTIVE： To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL： We retrieved publications from Cochrane Library （2004 to July 2011）, PubMed （1966 to July 2011）, the Chinese Science and Technique Journals Database （1977 to July 2011）, the China National Knowledge Infrastructure （1979 to July 2011）, Google Scholar （July 2011）, and the Chinese Biomedical Database （1977 to July 2011） using the key words ＂Chinese medicine OR Chinese herbal medicine＂ and ＂vascular dementia OR mild cognition impair OR multi-infarct dementia OR small-vessel dementia OR strategic infarct dementia OR hypoperfusion dementia OR hemorrhagic dementia OR hereditary vascular dementia＂. SELECTION CRITERIA： Randomized controlled trials comparing Chinese herbal medicines with placebo/western medicine in the treatment of patients with vascular dementia were included. Diagnostic standards included Diagnostic and Statistical Manual of Mental Disorders-IV, and National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et I＇Enseignement en Neurosciences. Two participants independently conducted literature screening, quality evaluation and data extraction. The quality of each trial was assessed according to the Cochrane Reviewers＇ Handbook 5.0. MAIN OUTCOME MEASURES： Effective rate, Mini-Mental State Examination scores, Hasegawa Dementia Scale scores, and incidence of adverse reactions. RESULTS： We identified 1 143 articles discussing the effects of Chinese medicine on vascular dementia. Thirty-one of these were included in the analysis. These studies involved a total of 2 868 participants （1 605 patients took Chinese medicine decoctions （treatment group）; 1 263 patients took western medicine or placebo）. The results of our meta-analysis revealed that Chinese herbal remedies in the treatment group were more efficacious than the control intervention （relative risk （RR）
