Objective: The pathogenesis of leukoaraiosis is still unclear. Many studies have determined that changes in the hemodynamics associated with leukoaraiosis, impaired cerebrovascular reserve, and intracranial hypoperfus...Objective: The pathogenesis of leukoaraiosis is still unclear. Many studies have determined that changes in the hemodynamics associated with leukoaraiosis, impaired cerebrovascular reserve, and intracranial hypoperfusion can lead to various clinical manifestations such as motor or cognitive impairment. The purpose of this study was to investigate the relationship between cognitive functional changes and imaging characteristics in patients with symptomatic leukoaraiosis, and to observe the corresponding changes in hemodynamics. Methods: A total of 203 Han patients (aged 43 - 93 years) with symptomatic leukoaraiosis were included in this study. Head magnetic resonance imaging was semi-quantified according to the Fazekas grading standard. Then, each patient was evaluated in terms of cognitive (Montreal scale) and executive function (trail-making test A [TMTA] and TMTB). Specifically, the TMTA asks patients to connect points on a piece of paper numbered from 1 to 25 in order and the TMTB asks patients to arrange numbers and letters in alternating order. In the current work, revised versions of these tests used are to include numbers in square and circular shapes where the shapes needed to be arranged in alternating order. The time required to complete the TMTA and TMTB was recorded. The changes in the blood flow velocity of the middle cerebral artery were also observed using routine Transcranial Doppler ultrasound and the breath-holding test. The dynamic curves of blood flow velocity during the breath-holding test were examined. Results: The cognitive and executive functions of patients with leukoaraiosis are related to the classification of image-based disease characteristics. In this sense, the more serious the leukoaraiosis is, the larger the impairment of cognitive and executive function is. According to the breath-holding test, the peak pattern of the blood flow velocity in the middle cerebral artery was significantly different between the various grades of leukoaraiosis. The peak type of Fazekas grade 0 and I w展开更多
目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿...目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿是否出现不良妊娠结局分为正常结局组(32例)与不良结局组(28例)。比较超声检查大脑中动脉(middle cerebral artery,MCA)及脐动脉(umbilical artery,UmA)血流情况,并对脉动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期峰值/舒张末期流速(systolic peak value and the end-diastolic velocity of blood flow,S/D)指标。结果孕30周时正常组MCA的PI、RI、S/D高于缺氧组,UmA的PI、RI、S/D低于缺氧组(P<0.05);正常结局组MCA的PI、RI、S/D高于不良结局组,UmA的PI、RI、S/D低于不良结局组(P<0.05)。结论应用超声检查可有效诊断胎儿大脑中动脉及脐动脉血流宫内缺氧和分娩结局,为胎儿宫内缺氧情况采取早期预防措施提供可靠依据,可有效避免围产儿出现不良结局,临床上可借鉴及推广。展开更多
文摘Objective: The pathogenesis of leukoaraiosis is still unclear. Many studies have determined that changes in the hemodynamics associated with leukoaraiosis, impaired cerebrovascular reserve, and intracranial hypoperfusion can lead to various clinical manifestations such as motor or cognitive impairment. The purpose of this study was to investigate the relationship between cognitive functional changes and imaging characteristics in patients with symptomatic leukoaraiosis, and to observe the corresponding changes in hemodynamics. Methods: A total of 203 Han patients (aged 43 - 93 years) with symptomatic leukoaraiosis were included in this study. Head magnetic resonance imaging was semi-quantified according to the Fazekas grading standard. Then, each patient was evaluated in terms of cognitive (Montreal scale) and executive function (trail-making test A [TMTA] and TMTB). Specifically, the TMTA asks patients to connect points on a piece of paper numbered from 1 to 25 in order and the TMTB asks patients to arrange numbers and letters in alternating order. In the current work, revised versions of these tests used are to include numbers in square and circular shapes where the shapes needed to be arranged in alternating order. The time required to complete the TMTA and TMTB was recorded. The changes in the blood flow velocity of the middle cerebral artery were also observed using routine Transcranial Doppler ultrasound and the breath-holding test. The dynamic curves of blood flow velocity during the breath-holding test were examined. Results: The cognitive and executive functions of patients with leukoaraiosis are related to the classification of image-based disease characteristics. In this sense, the more serious the leukoaraiosis is, the larger the impairment of cognitive and executive function is. According to the breath-holding test, the peak pattern of the blood flow velocity in the middle cerebral artery was significantly different between the various grades of leukoaraiosis. The peak type of Fazekas grade 0 and I w
文摘目的建立应用超声多谱勒技术测量各孕周胎儿大脑中动脉峰值血流速度(middle cerebral artery peak systolic velocity,MCV-PSV)的正常值。方法对1197例次的胎儿进行各孕周大脑中动脉峰值血流速度进行测量,计算中位数,百分位数,1.5倍中位数(multiples of the median,MOM表示)。结果胎儿大脑中动脉峰值血流速度随着孕周增加而升高。结论利用这不同孕周正常值数据,算出1.5倍中位数值作为判断胎儿宫内贫血状态的指标。
文摘目的探讨超声检查在胎儿大脑中动脉及脐动脉血流在胎儿宫内缺氧及分娩结局诊断中的应用价值。方法选取2020年8月—2022年2月广东省中山市东凤人民医院收治的孕妇60例,根据是否出现宫内缺氧分为缺氧组(31例)与正常组(29例),再根据围产儿是否出现不良妊娠结局分为正常结局组(32例)与不良结局组(28例)。比较超声检查大脑中动脉(middle cerebral artery,MCA)及脐动脉(umbilical artery,UmA)血流情况,并对脉动指数(pulsatility index,PI)、阻力指数(resistance index,RI)、收缩期峰值/舒张末期流速(systolic peak value and the end-diastolic velocity of blood flow,S/D)指标。结果孕30周时正常组MCA的PI、RI、S/D高于缺氧组,UmA的PI、RI、S/D低于缺氧组(P<0.05);正常结局组MCA的PI、RI、S/D高于不良结局组,UmA的PI、RI、S/D低于不良结局组(P<0.05)。结论应用超声检查可有效诊断胎儿大脑中动脉及脐动脉血流宫内缺氧和分娩结局,为胎儿宫内缺氧情况采取早期预防措施提供可靠依据,可有效避免围产儿出现不良结局,临床上可借鉴及推广。
