Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of poly...Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of polycyclic aromatic hydrocarbons (PAHs) in Chinese pregnant women and their newborns, and to examine the association between levels of PAHs and infant birth weight. We conducted a cross-sectional study including 81 pairs of mothers and newborns from four hospitals in four different cities in China. High Performance Liquid Chromatography was used to measure the concentration of nine PAHs in maternal and cord blood and multiple linear regression analyses were used to evaluate the associations of these PAHs with infant birth weight. Anthracene (ANT) had the highest average concentration and detection rate (geometric mean = 69.54 ng/g and 76.5%, respectively) in maternal serum samples, while fluoranthene (FLT) had the highest concentration and detection rate (geometric mean = 68.4 ng/g and 50.6%, respectively) in the cord blood. Most of the measured PAHs in maternal serum and three PAHs in cord blood were inversely but non-significantly associated with birth weight. The strongest associations were observed for higher concentrations of benzo (a) pyrene (BaP) in maternal serum (230.7 g decrease for levels > median vs. < LOD;p = 0.151) and for ANT in cord blood (153.1 g decrease for levels < median vs. < LOD;p = 0.208). Ant and FLT were the predominant PAHs in the maternal and cord blood serum. Serum concentrations of several measured PAHs were associated with a decreased birth weight, although not significantly, suggesting that further studies with larger sample sizes are needed to validate our findings.展开更多
目的通过对早期联合筛查设定模式即NT＋PAPP-A＋Free-β-HCG研究,建立超声NT指标中位倍数（multiple of the median Mo M）值;研究21-三体综合征多个筛查指标中位倍数（Mo M）值改变的变化规律。方法入选691例妊娠11~13＋6w进行产前筛...目的通过对早期联合筛查设定模式即NT＋PAPP-A＋Free-β-HCG研究,建立超声NT指标中位倍数（multiple of the median Mo M）值;研究21-三体综合征多个筛查指标中位倍数（Mo M）值改变的变化规律。方法入选691例妊娠11~13＋6w进行产前筛查的妊娠妇女,超声检测胎儿颈项透明层（nuchal translucency,NT）厚度,同时取妊娠妇女静脉血,以时间分辨法检测血清生化标记物妊娠相关血浆蛋白A（PAPP-A）、游离β-人绒毛膜促性腺激素（Free-β-HCG）,并根据患者年龄、体重、种族、妊娠周数、吸烟史等将以上3个指标转化成各自指标的中位数倍数（Mo M）;同时随访妊娠结局。结果 1建立温州正常孕妇群NT中位值数据库,NT_Mo M与PAPP-A、Free-β-HCG_Mo M值无相关性（P均=0.789）;2691例入选对象中,669例正常胎儿,22例异常胎儿,其中包括9例21-三体综合征,2例18-三体异常,11例超声表现异常未行染色体核型检查;以NT_Mo M〉2.0 Mo M、PAPP-A_Mo M〈0.4 Mo M、Free-β-HCG_Mo M〉2.0 Mo M为截断值,21-三体综合征检出率为8/9=88.9%;结论 21-三体综合征多指标改变有一致性,多指标联合筛查可提高胎儿异常检出率;正常孕妇群数据的建立为早期筛查方案在临床推广应用奠定基础。展开更多
文摘Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of polycyclic aromatic hydrocarbons (PAHs) in Chinese pregnant women and their newborns, and to examine the association between levels of PAHs and infant birth weight. We conducted a cross-sectional study including 81 pairs of mothers and newborns from four hospitals in four different cities in China. High Performance Liquid Chromatography was used to measure the concentration of nine PAHs in maternal and cord blood and multiple linear regression analyses were used to evaluate the associations of these PAHs with infant birth weight. Anthracene (ANT) had the highest average concentration and detection rate (geometric mean = 69.54 ng/g and 76.5%, respectively) in maternal serum samples, while fluoranthene (FLT) had the highest concentration and detection rate (geometric mean = 68.4 ng/g and 50.6%, respectively) in the cord blood. Most of the measured PAHs in maternal serum and three PAHs in cord blood were inversely but non-significantly associated with birth weight. The strongest associations were observed for higher concentrations of benzo (a) pyrene (BaP) in maternal serum (230.7 g decrease for levels > median vs. < LOD;p = 0.151) and for ANT in cord blood (153.1 g decrease for levels < median vs. < LOD;p = 0.208). Ant and FLT were the predominant PAHs in the maternal and cord blood serum. Serum concentrations of several measured PAHs were associated with a decreased birth weight, although not significantly, suggesting that further studies with larger sample sizes are needed to validate our findings.
文摘目的通过对早期联合筛查设定模式即NT＋PAPP-A＋Free-β-HCG研究,建立超声NT指标中位倍数（multiple of the median Mo M）值;研究21-三体综合征多个筛查指标中位倍数（Mo M）值改变的变化规律。方法入选691例妊娠11~13＋6w进行产前筛查的妊娠妇女,超声检测胎儿颈项透明层（nuchal translucency,NT）厚度,同时取妊娠妇女静脉血,以时间分辨法检测血清生化标记物妊娠相关血浆蛋白A（PAPP-A）、游离β-人绒毛膜促性腺激素（Free-β-HCG）,并根据患者年龄、体重、种族、妊娠周数、吸烟史等将以上3个指标转化成各自指标的中位数倍数（Mo M）;同时随访妊娠结局。结果 1建立温州正常孕妇群NT中位值数据库,NT_Mo M与PAPP-A、Free-β-HCG_Mo M值无相关性（P均=0.789）;2691例入选对象中,669例正常胎儿,22例异常胎儿,其中包括9例21-三体综合征,2例18-三体异常,11例超声表现异常未行染色体核型检查;以NT_Mo M〉2.0 Mo M、PAPP-A_Mo M〈0.4 Mo M、Free-β-HCG_Mo M〉2.0 Mo M为截断值,21-三体综合征检出率为8/9=88.9%;结论 21-三体综合征多指标改变有一致性,多指标联合筛查可提高胎儿异常检出率;正常孕妇群数据的建立为早期筛查方案在临床推广应用奠定基础。
