采用剂量率为20 k Gy/h的电子束在空气氛围中对乙烯-四氟乙烯共聚物(Ethylene tetra-fluoro-ethylenecopolymer,ETFE)片材进行辐照,剂量范围0–1600 k Gy,研究了ETFE片材在低剂量率电子束辐照下的化学稳定性。通过机械性能、红外光谱、...采用剂量率为20 k Gy/h的电子束在空气氛围中对乙烯-四氟乙烯共聚物(Ethylene tetra-fluoro-ethylenecopolymer,ETFE)片材进行辐照,剂量范围0–1600 k Gy,研究了ETFE片材在低剂量率电子束辐照下的化学稳定性。通过机械性能、红外光谱、拉曼光谱和扫描量热仪(DSC)等对辐照前后的样品进行了测试和表征。机械性能测试结果表明,随着吸收剂量的增加,断裂伸长率和断裂强度在0–200 k Gy内缓慢下降,超过400 k Gy则急剧下降;红外光谱分析表明,随着吸收剂量的增加,羰基指数增加,样品表面氧化程度严重;拉曼光谱分析结果显示低剂量率电子束的辐照破坏了ETFE分子链结构的对称性;DSC测试结果表明,随着吸收剂量的增加,ETFE的结晶度和熔点逐渐下降,结晶度从43.2%下降到12.6%,熔点从261.3℃下降到233.3℃。展开更多
We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enro...We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups： the low-dose tacrolimus group （group A） and the normal-dose tacrolimus group （group B）. The blood concentration of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the survival rates of the recipients were analyzed at the 1and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dysfunction and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients.展开更多
文摘采用剂量率为20 k Gy/h的电子束在空气氛围中对乙烯-四氟乙烯共聚物(Ethylene tetra-fluoro-ethylenecopolymer,ETFE)片材进行辐照,剂量范围0–1600 k Gy,研究了ETFE片材在低剂量率电子束辐照下的化学稳定性。通过机械性能、红外光谱、拉曼光谱和扫描量热仪(DSC)等对辐照前后的样品进行了测试和表征。机械性能测试结果表明,随着吸收剂量的增加,断裂伸长率和断裂强度在0–200 k Gy内缓慢下降,超过400 k Gy则急剧下降;红外光谱分析表明,随着吸收剂量的增加,羰基指数增加,样品表面氧化程度严重;拉曼光谱分析结果显示低剂量率电子束的辐照破坏了ETFE分子链结构的对称性;DSC测试结果表明,随着吸收剂量的增加,ETFE的结晶度和熔点逐渐下降,结晶度从43.2%下降到12.6%,熔点从261.3℃下降到233.3℃。
文摘We sought to evaluate the efficacy and effects of low-dose tacrolimus （FK506） to recipients with living donor liver transplantation （LDLT）. A total of 66 patients who underwent LDLT between 2001 and 2007 were enrolled in this study. According to different doses of tacrolimus, the recipients were randomly divided into two groups： the low-dose tacrolimus group （group A） and the normal-dose tacrolimus group （group B）. The blood concentration of tacrolimus and its side effects including infection, hyperglycemia, hypertension, high blood creatinine and jaundice were monitored once a week at the perioperative period, and once a month thereafter. Besides, the survival rates of the recipients were analyzed at the 1and 3-year time point after operation. Among these patients, no significant acute rejection was detected after LDLT. The incidences of infection, hyperglycemia, liver dysfunction and renal impairment in group A were markedly lower than those in group B. However, no significant differences were detected in the incidence of hypertension between the two groups. Moreover, the recipients in each group had a similar survival rate according to the results of 1and 3-year follow-up. The incidence of side effects that associated with tacrolimus positively correlated with tacrolimus blood concentration. In conclusion, long-term and low-dose administration of tacrolimus is a safe and effective treatment for LDLT recipients.
