Optical axial scanning is essential process to obtain 3D information of biological specimens. To realize optical axial scanning without moving, the tunable lens is a solution. However, the conventional tunable lenses ...Optical axial scanning is essential process to obtain 3D information of biological specimens. To realize optical axial scanning without moving, the tunable lens is a solution. However, the conventional tunable lenses usually induce non-uniform magnification and resolution issues. In this paper, we report a movable electrowetting optofluidic lens. Unlike the conventional tunable lens, our proposed optofluidic lens has two liquid-liquid (L-L) interfaces, which can move in the cell by an external voltage. The object distance and image distance are adjusted by shifting the L-L interface position. Therefore, the proposed lens can realize optical axial scanning with uniform magnification and resolution in microscopy. To prove the concept, we fabricate an optofluidic lens and use it in optical axial scanning. The scanning distance is more than 1 mm with uniform magnification and good imaging quality. Widespread application of such a new adaptive zoom lens is foreseeable.展开更多
The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves t...The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves the muscles of the upper and/or lower extremities,and the muscles of the bulbar and/or respiratory regions.However,as the disease progresses,it affects the adjacent body regions,leading to generalized muscle weakness,occasionally along with memory,cognitive,behavioral,and language impairments;respiratory dysfunction occurs at the final stage of the disease.The disease has a complicated pathophysiology and currently,only riluzole,edaravone,and phenylbutyrate/taurursodiol are licensed to treat amyotrophic lateral sclerosis in many industrialized countries.The TAR DNA-binding protein 43 inclusions are observed in 97%of those diagnosed with amyotrophic lateral sclerosis.This review provides a preliminary overview of the potential effects of TAR DNAbinding protein 43 in the pathogenesis of amyotrophic lateral sclerosis,including the abnormalities in nucleoplasmic transport,RNA function,post-translational modification,liquid-liquid phase separation,stress granules,mitochondrial dysfunction,oxidative stress,axonal transport,protein quality control system,and non-cellular autonomous functions(e.g.,glial cell functions and prion-like propagation).展开更多
In this paper, the couple vibration of liquid and elastic spacer in arectangular tank is investigated. Two different velocity potential functions correspondingrespectively to the liquid above and below the elastic spa...In this paper, the couple vibration of liquid and elastic spacer in arectangular tank is investigated. Two different velocity potential functions correspondingrespectively to the liquid above and below the elastic spacer are assumed. Complicated boundaryconditions corresponding to two velocity potential functions and vibrations of elastic spacer aregiven. Using the method of energy, the equation of couple frequency is obtained. Through numericalcomputation the natural frequencies that change according to the location and stiffness of thespacer are shown.展开更多
文摘Optical axial scanning is essential process to obtain 3D information of biological specimens. To realize optical axial scanning without moving, the tunable lens is a solution. However, the conventional tunable lenses usually induce non-uniform magnification and resolution issues. In this paper, we report a movable electrowetting optofluidic lens. Unlike the conventional tunable lens, our proposed optofluidic lens has two liquid-liquid (L-L) interfaces, which can move in the cell by an external voltage. The object distance and image distance are adjusted by shifting the L-L interface position. Therefore, the proposed lens can realize optical axial scanning with uniform magnification and resolution in microscopy. To prove the concept, we fabricate an optofluidic lens and use it in optical axial scanning. The scanning distance is more than 1 mm with uniform magnification and good imaging quality. Widespread application of such a new adaptive zoom lens is foreseeable.
基金in part supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198,and 82160255Education Department of Jiangxi Province,Nos.GJJ13198 and GJJ170021+1 种基金Jiangxi Provincial Department of Science and Technology,No.20192BAB205043Health and Family Planning Commission of Jiangxi Province,Nos.20181019 and 202210002(all to RX)。
文摘The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves the muscles of the upper and/or lower extremities,and the muscles of the bulbar and/or respiratory regions.However,as the disease progresses,it affects the adjacent body regions,leading to generalized muscle weakness,occasionally along with memory,cognitive,behavioral,and language impairments;respiratory dysfunction occurs at the final stage of the disease.The disease has a complicated pathophysiology and currently,only riluzole,edaravone,and phenylbutyrate/taurursodiol are licensed to treat amyotrophic lateral sclerosis in many industrialized countries.The TAR DNA-binding protein 43 inclusions are observed in 97%of those diagnosed with amyotrophic lateral sclerosis.This review provides a preliminary overview of the potential effects of TAR DNAbinding protein 43 in the pathogenesis of amyotrophic lateral sclerosis,including the abnormalities in nucleoplasmic transport,RNA function,post-translational modification,liquid-liquid phase separation,stress granules,mitochondrial dysfunction,oxidative stress,axonal transport,protein quality control system,and non-cellular autonomous functions(e.g.,glial cell functions and prion-like propagation).
文摘In this paper, the couple vibration of liquid and elastic spacer in arectangular tank is investigated. Two different velocity potential functions correspondingrespectively to the liquid above and below the elastic spacer are assumed. Complicated boundaryconditions corresponding to two velocity potential functions and vibrations of elastic spacer aregiven. Using the method of energy, the equation of couple frequency is obtained. Through numericalcomputation the natural frequencies that change according to the location and stiffness of thespacer are shown.
