Head and neck squamous cell carcinoma(HNSCC)represents the sixth most common malignancy worldwide.However,very few established diagnostic biomarkers for HNSCC have been universally applied in clinical practice.Recentl...Head and neck squamous cell carcinoma(HNSCC)represents the sixth most common malignancy worldwide.However,very few established diagnostic biomarkers for HNSCC have been universally applied in clinical practice.Recently,much attention has been paid to extracellular vesicles(EVs)regarding their roles as cancer biomarkers because EVs carry plentiful cargoes,including lipids,proteins,nucleic acids,and metabolites.In HNSCC,several molecules carried by EVs,which are derived from peripheral blood and saliva,have been implicated to be effective in cancer detection,staging,treatment planning,response monitoring,and prognosis prediction.Although several EV molecules have been identified to be significantly correlated with a set of clinicalpathological parameters of HNSCC,several key limitations need to be resolved before the clinical application of EVs as carriers of biomarkers in HNSCC.In this review,we discuss current knowledge in the literature regarding EV-based biomarkers in HNSCC,emphasizing current limitations of their clinical applications.展开更多
According to the experimental data of the orifice discharge coefficient for the flow through a vertical sharp-edged orifice obtained in the previous study of this work,a theoretical criterion for flow mechanisms of sm...According to the experimental data of the orifice discharge coefficient for the flow through a vertical sharp-edged orifice obtained in the previous study of this work,a theoretical criterion for flow mechanisms of small orifice（viz.thick-walled orifice and nozzle） and large orifice（viz.thin-walled orifice） was proposed based on the ratio of orifice diameter to plate thickness.It can help explain the dissipation of the mechanical energy loss in the flow process for the two flow mechanisms under different operating regimes.The main parameters such as orifice diameter,plate thickness and liquid head were correlated,and a semi-empirical model for orifice coefficient and an empirical model with high precision at the stable region were developed.展开更多
目的:观察活血散外敷联合三七化瘀口服液对治疗早期股骨头缺血性坏死(Ischemic Osteonecrosis of the Femoral Head,ANFH)的临床疗效。方法:采用随机数字表法将60例早期股骨头缺血性坏死患者随机分为两组:治疗组30例,以三七化瘀口服液...目的:观察活血散外敷联合三七化瘀口服液对治疗早期股骨头缺血性坏死(Ischemic Osteonecrosis of the Femoral Head,ANFH)的临床疗效。方法:采用随机数字表法将60例早期股骨头缺血性坏死患者随机分为两组:治疗组30例,以三七化瘀口服液内服加活血散外敷治疗;对照组30例,仅以三七化瘀口服液内服治疗,治疗期间均嘱患者注意保护性负重。两组均以28d为1个疗程,连续治疗3个疗程后比较患者治疗前后的Harris髋关节功能评分和临床疗效。结果:治疗组患者Harris髋关节功能评分与临床总疗效改善程度均优于对照组,差异均有统计学意义(P<0.05)。结论:三七化瘀口服液内服配合活血散外敷治疗早期股骨头缺血性坏死疗效满意,优于单纯三七化瘀口服液内服治疗。展开更多
基金National Natural Science Foundation of China(81872196,81672690,81772900,81972541,and 81672690).
文摘Head and neck squamous cell carcinoma(HNSCC)represents the sixth most common malignancy worldwide.However,very few established diagnostic biomarkers for HNSCC have been universally applied in clinical practice.Recently,much attention has been paid to extracellular vesicles(EVs)regarding their roles as cancer biomarkers because EVs carry plentiful cargoes,including lipids,proteins,nucleic acids,and metabolites.In HNSCC,several molecules carried by EVs,which are derived from peripheral blood and saliva,have been implicated to be effective in cancer detection,staging,treatment planning,response monitoring,and prognosis prediction.Although several EV molecules have been identified to be significantly correlated with a set of clinicalpathological parameters of HNSCC,several key limitations need to be resolved before the clinical application of EVs as carriers of biomarkers in HNSCC.In this review,we discuss current knowledge in the literature regarding EV-based biomarkers in HNSCC,emphasizing current limitations of their clinical applications.
基金supported by the National Natural Science Foundation of China(20806090)
文摘According to the experimental data of the orifice discharge coefficient for the flow through a vertical sharp-edged orifice obtained in the previous study of this work,a theoretical criterion for flow mechanisms of small orifice（viz.thick-walled orifice and nozzle） and large orifice（viz.thin-walled orifice） was proposed based on the ratio of orifice diameter to plate thickness.It can help explain the dissipation of the mechanical energy loss in the flow process for the two flow mechanisms under different operating regimes.The main parameters such as orifice diameter,plate thickness and liquid head were correlated,and a semi-empirical model for orifice coefficient and an empirical model with high precision at the stable region were developed.
文摘目的:观察活血散外敷联合三七化瘀口服液对治疗早期股骨头缺血性坏死(Ischemic Osteonecrosis of the Femoral Head,ANFH)的临床疗效。方法:采用随机数字表法将60例早期股骨头缺血性坏死患者随机分为两组:治疗组30例,以三七化瘀口服液内服加活血散外敷治疗;对照组30例,仅以三七化瘀口服液内服治疗,治疗期间均嘱患者注意保护性负重。两组均以28d为1个疗程,连续治疗3个疗程后比较患者治疗前后的Harris髋关节功能评分和临床疗效。结果:治疗组患者Harris髋关节功能评分与临床总疗效改善程度均优于对照组,差异均有统计学意义(P<0.05)。结论:三七化瘀口服液内服配合活血散外敷治疗早期股骨头缺血性坏死疗效满意,优于单纯三七化瘀口服液内服治疗。
