Embryonic development is critical for the final functionality and maintenance of the adult brain. Brain development is tightly regulated by intracellular and extracellular signaling. Lysine acetylation and deacetylati...Embryonic development is critical for the final functionality and maintenance of the adult brain. Brain development is tightly regulated by intracellular and extracellular signaling. Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracelhdar responses. A wealth of evidence indicates that lysine acetylation and deacetylation are critical for brain development and functionality. Indeed, mutations of the enzymes and cofactors responsible for these processes are often associated with neurodevelopmental and psychiatric disorders. Lysine acetylation and deacetylation are involved in all levels of brain development, starting from neuroprogenitor survival and proliferation, cell fate decisions, neuronal maturation, migration, and synaptogenesis, as well as differentiation and maturation of astrocytes and oligodendrocytes, to the establishment of neuronal circuits. Hence, fluctuations in the balance between lysine acetylation and deacetylation contribute to the final shape and perrformance of the brain. In this review, we summarize the current basic knowledge on the specific roles of lysine acetyltransferase （KAT） and lysine deacetylase （KDAC） complexes in brain development and the different neurodevelopmental disorders that are associated with dysfunctional lysine （de）acetylation machineries.展开更多
英国品牌携手布鲁克里本土刺绣艺术家Richard Saja献上高级时装与运动装糅合的时装秀。世界上有很多相互陌生的时尚合作,但很少有像Mother of Pearl的故事一样引人注目。Mother of Pearl是Maia Norman在2010年创建的英国奢华运动服装线...英国品牌携手布鲁克里本土刺绣艺术家Richard Saja献上高级时装与运动装糅合的时装秀。世界上有很多相互陌生的时尚合作,但很少有像Mother of Pearl的故事一样引人注目。Mother of Pearl是Maia Norman在2010年创建的英国奢华运动服装线。他们的合作并不是商业炒作的手段,而是品牌DNA的一部分,每个系列品牌都会与不同艺术家的合作创造出限量版的产品。＂这是真实的世界,展开更多
In his Commentary on Plato＇s Phaedo, Damascius establishes a close relation between destination （lexis）, divine Justice, and life dignity （kat＇aian） of every soul. Among several meanings of destination, the most...In his Commentary on Plato＇s Phaedo, Damascius establishes a close relation between destination （lexis）, divine Justice, and life dignity （kat＇aian） of every soul. Among several meanings of destination, the most relevant one is related to the condition of the soul after death. Consequently, the purpose of this paper is to consider how this neoplatonic term is conceived in Dionysius Areopagite. For that purpose, the author will analyze such term widely used in the chapter 7 of Ecclesiastic Hierarchy in which Dionysius deals with the funerary rite and in which the notes of the dionysian eschatology are found. In other words, Dionysius＇ use of this term combines a spiritual and a metaphysic perspective. The former is part of the representation of the dionysian universe in which even the angels receive the name of lexeis and are distinguished by their never ending movement around the Thearchia; the latter is present among humans as a call to imitate such angelic condition. Such imitation is not possible without the effort needed to behave in agreement with an honorable lifestyle （kat＇axian, neoplatonic expression also used by Dionysius） that opens the door to a condition or rank granted to man after death.展开更多
＂从科学角度来讲,我们还没有解决EMS的方法,我们也不知道EMS的根源是什么,我们来参加这个论坛,表明我们是很认真想解决这个问题,我们也想了解一下中国究竟怎样来解决这个问题,这是一个双向的交流。＂马来西亚Kembang Subur集团总经理Je...＂从科学角度来讲,我们还没有解决EMS的方法,我们也不知道EMS的根源是什么,我们来参加这个论坛,表明我们是很认真想解决这个问题,我们也想了解一下中国究竟怎样来解决这个问题,这是一个双向的交流。＂马来西亚Kembang Subur集团总经理Jeffrey Lee Kat Choy在第五届中国对虾产业发展论坛上,对于EMS爆发的根源发表了自己的看法。展开更多
基金partially supported by the Deutsche Forschungsgemeinschaft(DFG),Germany
文摘Embryonic development is critical for the final functionality and maintenance of the adult brain. Brain development is tightly regulated by intracellular and extracellular signaling. Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracelhdar responses. A wealth of evidence indicates that lysine acetylation and deacetylation are critical for brain development and functionality. Indeed, mutations of the enzymes and cofactors responsible for these processes are often associated with neurodevelopmental and psychiatric disorders. Lysine acetylation and deacetylation are involved in all levels of brain development, starting from neuroprogenitor survival and proliferation, cell fate decisions, neuronal maturation, migration, and synaptogenesis, as well as differentiation and maturation of astrocytes and oligodendrocytes, to the establishment of neuronal circuits. Hence, fluctuations in the balance between lysine acetylation and deacetylation contribute to the final shape and perrformance of the brain. In this review, we summarize the current basic knowledge on the specific roles of lysine acetyltransferase （KAT） and lysine deacetylase （KDAC） complexes in brain development and the different neurodevelopmental disorders that are associated with dysfunctional lysine （de）acetylation machineries.
文摘英国品牌携手布鲁克里本土刺绣艺术家Richard Saja献上高级时装与运动装糅合的时装秀。世界上有很多相互陌生的时尚合作,但很少有像Mother of Pearl的故事一样引人注目。Mother of Pearl是Maia Norman在2010年创建的英国奢华运动服装线。他们的合作并不是商业炒作的手段,而是品牌DNA的一部分,每个系列品牌都会与不同艺术家的合作创造出限量版的产品。＂这是真实的世界,
文摘In his Commentary on Plato＇s Phaedo, Damascius establishes a close relation between destination （lexis）, divine Justice, and life dignity （kat＇aian） of every soul. Among several meanings of destination, the most relevant one is related to the condition of the soul after death. Consequently, the purpose of this paper is to consider how this neoplatonic term is conceived in Dionysius Areopagite. For that purpose, the author will analyze such term widely used in the chapter 7 of Ecclesiastic Hierarchy in which Dionysius deals with the funerary rite and in which the notes of the dionysian eschatology are found. In other words, Dionysius＇ use of this term combines a spiritual and a metaphysic perspective. The former is part of the representation of the dionysian universe in which even the angels receive the name of lexeis and are distinguished by their never ending movement around the Thearchia; the latter is present among humans as a call to imitate such angelic condition. Such imitation is not possible without the effort needed to behave in agreement with an honorable lifestyle （kat＇axian, neoplatonic expression also used by Dionysius） that opens the door to a condition or rank granted to man after death.
文摘＂从科学角度来讲,我们还没有解决EMS的方法,我们也不知道EMS的根源是什么,我们来参加这个论坛,表明我们是很认真想解决这个问题,我们也想了解一下中国究竟怎样来解决这个问题,这是一个双向的交流。＂马来西亚Kembang Subur集团总经理Jeffrey Lee Kat Choy在第五届中国对虾产业发展论坛上,对于EMS爆发的根源发表了自己的看法。
