Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32...Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32 patients 1, 2, 3 and 7 days after craniocerebral injury. Repeated cranial CT scans and platelet counts were made simultaneously. Same measurements were done in 30 normal adults except CT scan. Results: No obvious difference was found in age, sex and platelet count between the injured and the normal groups. TFPI/TF decreased markedly in the first week after injury in patients with SBI, but only decreased on the 7th day in the patients without obvious SBI. For the patients who developed delayed intracranial hematoma (DIH) or hematoma enlargement, TF rose only 1 and 2 days after injury, but TFPI had a tendency to rise again after a fall on the 3rd day. For those patients who developed no DIH, TF rose all the time within the 1st week. Conclusions: Decrease of TFPI/TF for a long time, especially within 3 days after injury, may be one of the most important reasons for SBI. High expression of TF for a relative short time and increase of TFPI after a fall within 3 days may be one of the important reasons for DIH or hematoma enlargement.展开更多
In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in th...In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault-terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil-~as fields locate herein.展开更多
Through the field survey, previous researches and interpretation of aerial photos, a landslide information database of Xiaojiang Valley, Yunnan Province was set up based on the remote sensing (RS) and geographic infor...Through the field survey, previous researches and interpretation of aerial photos, a landslide information database of Xiaojiang Valley, Yunnan Province was set up based on the remote sensing (RS) and geographic information system (GIS) technologies. In the paper, a quantitative model for the landslide hazard assessment and zoning was presented, in which the potential energy could be obtained on basis of thorough analysis of the potential sliding volume, distance and direction of the landslide body. Taking landslide potential energy as the index of the hazard severity zonation, the study area was divided into severe, heavy, medium and light hazard zones.展开更多
2007年5月发现危害青檀的一种蚜虫,经鉴定为斑蚜科(Drepanosiphidae)、绵叶蚜属(Shivaphis Das 1918)一新种,命名为青檀绵叶蚜(Shivaphis pteroceltis Qiao,Jiang and An,sp.nov)。据笔者2007—2013年调查发现青檀绵叶蚜为单食性蚜虫,...2007年5月发现危害青檀的一种蚜虫,经鉴定为斑蚜科(Drepanosiphidae)、绵叶蚜属(Shivaphis Das 1918)一新种,命名为青檀绵叶蚜(Shivaphis pteroceltis Qiao,Jiang and An,sp.nov)。据笔者2007—2013年调查发现青檀绵叶蚜为单食性蚜虫,寄主仅为青檀,在山东、河南、山西、北京、安徽等地的青檀自然分布区均有分布,在山东省枣庄市已对青檀造成严重危害。该虫若蚜及成蚜吸食叶片、幼果及幼嫩枝条汁液导致叶片失绿,影响树木生长及结果;虫体分泌的蜜露容易引起枝叶发生煤污病,严重影响风景观瞻和生态景观。青檀绵叶蚜在树冠部位呈聚集分布,分布规律为树冠底层>中层>上层,内部>中部>外部。展开更多
Two redundant blue-light receptors, known as phototropins （phot1 and phot2）, influence a variety of physiological responses, including phototropism, chloroplast positioning, and stomatal opening in Arabidopsis thali...Two redundant blue-light receptors, known as phototropins （phot1 and phot2）, influence a variety of physiological responses, including phototropism, chloroplast positioning, and stomatal opening in Arabidopsis thaliana. Whereas photl functions in both low- and high-intensity blue light （HBL）, phot2 functions primarily in HBL. Here, we aimed to elucidate phot2-specific functions by screening for HBL- insensitive mutants among mutagenized Arabidopsis photl mutants. One of the resulting phot2 signaling associated （p2sa） double mutants, phot1 p2sa2, exhibited phototropic defects that could be restored by constitutively expressing NON-PHOTOTROPIC HYPOCOTYL 3 （NPH3）, indicating that P2SA2 was allelic to NPH3. It was observed that NPH3-GFP signal mainly localized to and clustered on the plasma membrane in darkness. This NPH3 clustering on the plasmamembrane was not affected by mutations in genes encoding proteins that interact with N PH3, including PHOT11, PHOT2 and ROOTPHOTOTROPISM 2 （RPT2）. However, the HBL irradiation- mediated release of NPH3 proteins into the cytoplasm was inhibited in photl mutants and enhanced in phot2 and rpt2-2 mutants. Furthermore, HBL-induced hypocotyl phototropism was enhanced in photl mutants and inhibited in the phot2 and rpt2-2 mutants. Our findings indicate that photl regulates the dissociation of NPH3 from the plasma membrane, whereas phot2 mediates the stabilization and relocation of NPH3 to the plasma membrane to acclimate to HBL.展开更多
The objective of the study is to evaluate and compare the effects of betaine or glycine on carcass trait,meat quality and lipid metabolism of finishing Huan Jiang mini-pigs.Betaine called trimethylglycine is a methyl ...The objective of the study is to evaluate and compare the effects of betaine or glycine on carcass trait,meat quality and lipid metabolism of finishing Huan Jiang mini-pigs.Betaine called trimethylglycine is a methyl derivative of glycine,but few researches were conducted to compare the impact of dietary betaine and glycine on pigs.One hundred and forty-four Huan Jiang mini-pigs(body weight=10.55±0.15 kg;70 d)were randomly divided to 3 treatment groups(basal diet,glycine or betaine).Results indicated that dietary betaine increased the average daily gain(ADG)and final weight(P<0.05).Dietary glycine or betaine markedly reduced average backfat thickness(P<0.05)and heightened lean percentage(P<0.01)compared to the control group.Moreover,in comparison with the control group,betaine significantly improved the redness(a*)and tenderness(shear force)of the longissimus dorsi(LD)muscle(P<0.05),whereas glycine only raised the value of a*of the LD muscle(P<0.05).These results showed that diet supplemented with 0.25%betaine and equimolar amounts of glycine could regulate cascass trait and meat quality of finishing Huan Jiang mini-pigs,and the effect of betaine was superior to that of glycine.展开更多
Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im...Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.展开更多
文摘Objective: To study the altering rule of coagulation function at molecular level in patients with secondary brain injury (SBI). Methods: Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were studied in 32 patients 1, 2, 3 and 7 days after craniocerebral injury. Repeated cranial CT scans and platelet counts were made simultaneously. Same measurements were done in 30 normal adults except CT scan. Results: No obvious difference was found in age, sex and platelet count between the injured and the normal groups. TFPI/TF decreased markedly in the first week after injury in patients with SBI, but only decreased on the 7th day in the patients without obvious SBI. For the patients who developed delayed intracranial hematoma (DIH) or hematoma enlargement, TF rose only 1 and 2 days after injury, but TFPI had a tendency to rise again after a fall on the 3rd day. For those patients who developed no DIH, TF rose all the time within the 1st week. Conclusions: Decrease of TFPI/TF for a long time, especially within 3 days after injury, may be one of the most important reasons for SBI. High expression of TF for a relative short time and increase of TFPI after a fall within 3 days may be one of the important reasons for DIH or hematoma enlargement.
基金supported jointly by the Open Fund (Grant No. PLC201105 & PLC201002) of the State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Chengdu University of Technology)the National Natural Science Foundation of China (Grant No. 40839902)the National Science & Technology Major Project (Grant No. 2011ZX05005-003-008HZ & 2011ZX05002-006-003HZ)
文摘In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault-terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil-~as fields locate herein.
基金Supported by the Special Project of Chinese Academy of sciences for Mountain Hazards: Debris Flow and Landslide and Oriented Project of Knowledge Innovation of Chinese Academy of sciences(KZCX2-SW-319)
文摘Through the field survey, previous researches and interpretation of aerial photos, a landslide information database of Xiaojiang Valley, Yunnan Province was set up based on the remote sensing (RS) and geographic information system (GIS) technologies. In the paper, a quantitative model for the landslide hazard assessment and zoning was presented, in which the potential energy could be obtained on basis of thorough analysis of the potential sliding volume, distance and direction of the landslide body. Taking landslide potential energy as the index of the hazard severity zonation, the study area was divided into severe, heavy, medium and light hazard zones.
文摘2007年5月发现危害青檀的一种蚜虫,经鉴定为斑蚜科(Drepanosiphidae)、绵叶蚜属(Shivaphis Das 1918)一新种,命名为青檀绵叶蚜(Shivaphis pteroceltis Qiao,Jiang and An,sp.nov)。据笔者2007—2013年调查发现青檀绵叶蚜为单食性蚜虫,寄主仅为青檀,在山东、河南、山西、北京、安徽等地的青檀自然分布区均有分布,在山东省枣庄市已对青檀造成严重危害。该虫若蚜及成蚜吸食叶片、幼果及幼嫩枝条汁液导致叶片失绿,影响树木生长及结果;虫体分泌的蜜露容易引起枝叶发生煤污病,严重影响风景观瞻和生态景观。青檀绵叶蚜在树冠部位呈聚集分布,分布规律为树冠底层>中层>上层,内部>中部>外部。
基金supported by the National Natural Science Foundation of China (31670289 and 31570294 to XZ)the National Key Research and Development Program of China (2016YFD0101900)
文摘Two redundant blue-light receptors, known as phototropins （phot1 and phot2）, influence a variety of physiological responses, including phototropism, chloroplast positioning, and stomatal opening in Arabidopsis thaliana. Whereas photl functions in both low- and high-intensity blue light （HBL）, phot2 functions primarily in HBL. Here, we aimed to elucidate phot2-specific functions by screening for HBL- insensitive mutants among mutagenized Arabidopsis photl mutants. One of the resulting phot2 signaling associated （p2sa） double mutants, phot1 p2sa2, exhibited phototropic defects that could be restored by constitutively expressing NON-PHOTOTROPIC HYPOCOTYL 3 （NPH3）, indicating that P2SA2 was allelic to NPH3. It was observed that NPH3-GFP signal mainly localized to and clustered on the plasma membrane in darkness. This NPH3 clustering on the plasmamembrane was not affected by mutations in genes encoding proteins that interact with N PH3, including PHOT11, PHOT2 and ROOTPHOTOTROPISM 2 （RPT2）. However, the HBL irradiation- mediated release of NPH3 proteins into the cytoplasm was inhibited in photl mutants and enhanced in phot2 and rpt2-2 mutants. Furthermore, HBL-induced hypocotyl phototropism was enhanced in photl mutants and inhibited in the phot2 and rpt2-2 mutants. Our findings indicate that photl regulates the dissociation of NPH3 from the plasma membrane, whereas phot2 mediates the stabilization and relocation of NPH3 to the plasma membrane to acclimate to HBL.
基金the National Key R&D Program(2018YFD0500405)the National Nature Science Foundation of China(31972582,U19A2037)+7 种基金the Changsha Natural Science Funds for Distinguished Young Scholar(kq2009020)Special funds for the construction of innovative provinces in Hunan Project(2019NK2193,2019RS3022)Open Fund of Key Laboratory of Agro-ecological Processes in Subtropical Region,Chinese Academy of Sciences(ISA2020203)the‘Strategic Priority Research Program’of the Chinese Academy of Sciences(XDA24030204)the Science and technology projects of Changsha City(kq1801059)Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process(2018TP1031)the General Program of National Natural Science Foundation of China(31872985)the Earmarked Fund for China Agriculture Research System(CARS-35).
文摘The objective of the study is to evaluate and compare the effects of betaine or glycine on carcass trait,meat quality and lipid metabolism of finishing Huan Jiang mini-pigs.Betaine called trimethylglycine is a methyl derivative of glycine,but few researches were conducted to compare the impact of dietary betaine and glycine on pigs.One hundred and forty-four Huan Jiang mini-pigs(body weight=10.55±0.15 kg;70 d)were randomly divided to 3 treatment groups(basal diet,glycine or betaine).Results indicated that dietary betaine increased the average daily gain(ADG)and final weight(P<0.05).Dietary glycine or betaine markedly reduced average backfat thickness(P<0.05)and heightened lean percentage(P<0.01)compared to the control group.Moreover,in comparison with the control group,betaine significantly improved the redness(a*)and tenderness(shear force)of the longissimus dorsi(LD)muscle(P<0.05),whereas glycine only raised the value of a*of the LD muscle(P<0.05).These results showed that diet supplemented with 0.25%betaine and equimolar amounts of glycine could regulate cascass trait and meat quality of finishing Huan Jiang mini-pigs,and the effect of betaine was superior to that of glycine.
基金supported by the National Key R&D Program of China(2018YFC1707300)the Taishan Industrial Experts Program(tscx202211148).
文摘Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.
