Purpose:To assess the efficacy and safety of a novel ophthalmic viscosurgical device-free(OVD-free)method for posterior chamber phakic intraocular lens(PIOL)implantation in myopic eyes.Methods:In this retrospective co...Purpose:To assess the efficacy and safety of a novel ophthalmic viscosurgical device-free(OVD-free)method for posterior chamber phakic intraocular lens(PIOL)implantation in myopic eyes.Methods:In this retrospective cohort study,the medical records of myopic eyes that underwent PIOL(Implantable Collamer Lens,ICL)implantation for myopia correction at the Eye Hospital of Wenzhou Medical University between May 2015 and March 2017 were reviewed.A total of 49 eyes with complete data that met follow up requirements(2 h,1 day,1 week,3 months postoperatively)were recruited.Based on the surgical techniques used,the eyes were divided into the OVD-free method group and the standard method group.The clinical data,including intraocular pressure(IOP),corrected distance visual acuity(CDVA)and spherical equivalent(SE),at each follow-up were collected for comparison.Endothelial cell loss and complications were also investigated.Results:Twenty-one eyes received the standard method,and 28 eyes received the OVD-free method.A rise in IOP>22 mmHg at 2 h was noted in 14 eyes(66.7%)in the standard group and none(0%)in the OVD-free group(p<0.001).The rise in IOP from baseline was significantly higher at 2 h in the standard group(10.5±5.2 mmHg vs.2.2±3.3 mmHg,difference:8.3,95%CI 5.8 to 10.8;p<0.001).There was a significant difference in the time course of LogMAR CDVA changes between the two groups(p=0.047).The LogMAR CDVA was significantly better in the OVD-free method group compared to the standard group at 1 day(−0.076,95%CI−0.134 to−0.018;p=0.012),1 week(−0.071,95%CI−0.135 to−0.007;p=0.03),but not at 3 months(−0.046,95%CI−0.107 to 0.015;p=0.134).There was no significant difference in the time course of SE changes between the two groups(p=0.471;p=0.705).In the OVD-free group,mean endothelial cell loss was 4.6%at 3 months(2522±281 vs.2407±226 cells/mm^(2),difference:-115,95%CI−295 to 65;p=0.187).No complications were reported in both groups except for the early IOP elevation in the standard group during the observat展开更多
AIM:To report outcomes of patients after intraocular lens(IOL)repositioning or exchange for the version of the uveitisglaucoma-hyphema(UGH)syndrome that does not include closed loop anterior chamber IOL(nUGH).METHODS:...AIM:To report outcomes of patients after intraocular lens(IOL)repositioning or exchange for the version of the uveitisglaucoma-hyphema(UGH)syndrome that does not include closed loop anterior chamber IOL(nUGH).METHODS:Chart review of patients with nUGH who underwent IOL repositioning or exchange by one surgeon were reviewed.The main outcome measures were best corrected visual acuity(BCVA)as a decimal fraction preoperatively and postoperatively after IOL repositioning or exchange.Clinical findings evaluated included the presence of uveitis,hyphema,elevated intraocular pressure(IOP),and other complications such as pigment dispersion or vitreous hemorrhage.The number of anti-inflammatory and glaucoma medications were assessed before and after IOL repositioning or exchange.RESULTS:The study included 14 pseudophakic eyes.The median time at the onset of contemporary UGH after cataract extraction and IOL implantation(CE/IOL)was7.5 y.IOL repositioning or exchange was performed at a mean duration of 8.1±4.7 mo(median:4 mo)after onset of UGH.The mean BCVA was improved from 0.45±0.26 preoperatively after onset of UGH syndrome to 0.76±0.22(P=0.016)after IOL repositioning or exchange.Among the14 eyes,uveitis,elevated IOP,and hyphema were present preoperatively in 13,13,and 6 eyes,respectively.Uveitis and hyphema resolved in all cases after IOL surgery.The mean IOP was reduced from 26.4±4.5 mm Hg preoperatively to 14.7±4.9 postoperatively(P=0.01).The mean number of glaucoma medications used was reduced from 1.7±1.1 medications preoperatively to 0.8±1.08(P=0.04)postoperatively.CONCLUSION:IOL repositioning or exchange is an effective treatment in many cases for medically resistant contemporary UGH syndrome.展开更多
目的观察白内障并发闭眼角型青光眼患者的临床治疗工作现状,分析行Phaco、人工晶体植入联合小梁切除术治疗的临床效果及术后并发症情况。方法借助统计软件将2018年1月至2019年12月期间在枣庄市薛城区人民医院眼科接受手术治疗的70例白...目的观察白内障并发闭眼角型青光眼患者的临床治疗工作现状,分析行Phaco、人工晶体植入联合小梁切除术治疗的临床效果及术后并发症情况。方法借助统计软件将2018年1月至2019年12月期间在枣庄市薛城区人民医院眼科接受手术治疗的70例白内障并发闭眼角型青光眼患者分为两组,对照组接受Phaco、人工晶体植入术治疗,研究组接受Phaco、人工晶体植入联合小梁切除术治疗,两组患者对比手术前后视力情况、眼内压力、超声生物显微镜指标、手术治疗效果及术后并发症情况。结果两组患者手术前视力[(4.52±0.11)比(4.50±0.13)]、眼压[(37.09±3.81)mmHg比(37.05±3.83)mmHg,1 mmHg=0.133 kPa]比较差异均无统计学意义(均P>0.05);研究组患者手术后视力提升情况高于对照组[(4.99±0.43)比(4.60±0.54)](P<0.05),而眼压低于对照组[(11.52±1.42)mmHg比(25.66±1.21)mmHg](P<0.05);两组患者手术前超声生物显微镜指标比较差异均无统计学意义(均P>0.05),研究组患者手术后30 d ACD、TIA、TCPD指标数值均高于对照组(均P<0.05),而AOD500指标数值低于对照组(P<0.05);研究组患者手术疗效评价高于对照组[97.14%(34/35)比68.87%(24/35)],而术后并发症发生率低于对照组[2.86%(1/35)比37.14%(13/35)],两组比较差异有统计学意义(P<0.05)。结论白内障并发闭眼角型青光眼患者接受Phaco、人工晶体植入、小梁切除术三联治疗,可有效改善视力、眼压及房角结果,减少术后并发症率,提高手术疗效,该三联治疗方式在临床上具有较高应用价值。展开更多
基金This study is supported by the National Natural Science Foundation of China(grant numbers 81570869)Zhejiang Provincial Natural Science Foundation of China(grant numbers Y2110784)+4 种基金Zhejiang Provincial Foundation of China for Distinguished Young Talents in Medicine and Health(grant numbers 2010QNA018)Wenzhou Key Team of Scientific and Technological Innovation(grant number C20170002)Foundation of Wenzhou City Science&Technology Bureau(grant numbers Y20140705)Engineering Development Project of Ophthalmology and Optometry(grant number GCKF201601)The funding organizations have no role in the design or conduct of this study.
文摘Purpose:To assess the efficacy and safety of a novel ophthalmic viscosurgical device-free(OVD-free)method for posterior chamber phakic intraocular lens(PIOL)implantation in myopic eyes.Methods:In this retrospective cohort study,the medical records of myopic eyes that underwent PIOL(Implantable Collamer Lens,ICL)implantation for myopia correction at the Eye Hospital of Wenzhou Medical University between May 2015 and March 2017 were reviewed.A total of 49 eyes with complete data that met follow up requirements(2 h,1 day,1 week,3 months postoperatively)were recruited.Based on the surgical techniques used,the eyes were divided into the OVD-free method group and the standard method group.The clinical data,including intraocular pressure(IOP),corrected distance visual acuity(CDVA)and spherical equivalent(SE),at each follow-up were collected for comparison.Endothelial cell loss and complications were also investigated.Results:Twenty-one eyes received the standard method,and 28 eyes received the OVD-free method.A rise in IOP>22 mmHg at 2 h was noted in 14 eyes(66.7%)in the standard group and none(0%)in the OVD-free group(p<0.001).The rise in IOP from baseline was significantly higher at 2 h in the standard group(10.5±5.2 mmHg vs.2.2±3.3 mmHg,difference:8.3,95%CI 5.8 to 10.8;p<0.001).There was a significant difference in the time course of LogMAR CDVA changes between the two groups(p=0.047).The LogMAR CDVA was significantly better in the OVD-free method group compared to the standard group at 1 day(−0.076,95%CI−0.134 to−0.018;p=0.012),1 week(−0.071,95%CI−0.135 to−0.007;p=0.03),but not at 3 months(−0.046,95%CI−0.107 to 0.015;p=0.134).There was no significant difference in the time course of SE changes between the two groups(p=0.471;p=0.705).In the OVD-free group,mean endothelial cell loss was 4.6%at 3 months(2522±281 vs.2407±226 cells/mm^(2),difference:-115,95%CI−295 to 65;p=0.187).No complications were reported in both groups except for the early IOP elevation in the standard group during the observat
基金The Bascom Palmer Eye Institute is supported by NIH Center Core(No.P30EY014801)a Research to Prevent Blindness Unrestricted GrantLee RK is supported by the Walter G.Ross Foundation。
文摘AIM:To report outcomes of patients after intraocular lens(IOL)repositioning or exchange for the version of the uveitisglaucoma-hyphema(UGH)syndrome that does not include closed loop anterior chamber IOL(nUGH).METHODS:Chart review of patients with nUGH who underwent IOL repositioning or exchange by one surgeon were reviewed.The main outcome measures were best corrected visual acuity(BCVA)as a decimal fraction preoperatively and postoperatively after IOL repositioning or exchange.Clinical findings evaluated included the presence of uveitis,hyphema,elevated intraocular pressure(IOP),and other complications such as pigment dispersion or vitreous hemorrhage.The number of anti-inflammatory and glaucoma medications were assessed before and after IOL repositioning or exchange.RESULTS:The study included 14 pseudophakic eyes.The median time at the onset of contemporary UGH after cataract extraction and IOL implantation(CE/IOL)was7.5 y.IOL repositioning or exchange was performed at a mean duration of 8.1±4.7 mo(median:4 mo)after onset of UGH.The mean BCVA was improved from 0.45±0.26 preoperatively after onset of UGH syndrome to 0.76±0.22(P=0.016)after IOL repositioning or exchange.Among the14 eyes,uveitis,elevated IOP,and hyphema were present preoperatively in 13,13,and 6 eyes,respectively.Uveitis and hyphema resolved in all cases after IOL surgery.The mean IOP was reduced from 26.4±4.5 mm Hg preoperatively to 14.7±4.9 postoperatively(P=0.01).The mean number of glaucoma medications used was reduced from 1.7±1.1 medications preoperatively to 0.8±1.08(P=0.04)postoperatively.CONCLUSION:IOL repositioning or exchange is an effective treatment in many cases for medically resistant contemporary UGH syndrome.
文摘目的观察白内障并发闭眼角型青光眼患者的临床治疗工作现状,分析行Phaco、人工晶体植入联合小梁切除术治疗的临床效果及术后并发症情况。方法借助统计软件将2018年1月至2019年12月期间在枣庄市薛城区人民医院眼科接受手术治疗的70例白内障并发闭眼角型青光眼患者分为两组,对照组接受Phaco、人工晶体植入术治疗,研究组接受Phaco、人工晶体植入联合小梁切除术治疗,两组患者对比手术前后视力情况、眼内压力、超声生物显微镜指标、手术治疗效果及术后并发症情况。结果两组患者手术前视力[(4.52±0.11)比(4.50±0.13)]、眼压[(37.09±3.81)mmHg比(37.05±3.83)mmHg,1 mmHg=0.133 kPa]比较差异均无统计学意义(均P>0.05);研究组患者手术后视力提升情况高于对照组[(4.99±0.43)比(4.60±0.54)](P<0.05),而眼压低于对照组[(11.52±1.42)mmHg比(25.66±1.21)mmHg](P<0.05);两组患者手术前超声生物显微镜指标比较差异均无统计学意义(均P>0.05),研究组患者手术后30 d ACD、TIA、TCPD指标数值均高于对照组(均P<0.05),而AOD500指标数值低于对照组(P<0.05);研究组患者手术疗效评价高于对照组[97.14%(34/35)比68.87%(24/35)],而术后并发症发生率低于对照组[2.86%(1/35)比37.14%(13/35)],两组比较差异有统计学意义(P<0.05)。结论白内障并发闭眼角型青光眼患者接受Phaco、人工晶体植入、小梁切除术三联治疗,可有效改善视力、眼压及房角结果,减少术后并发症率,提高手术疗效,该三联治疗方式在临床上具有较高应用价值。
