AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol syste...AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.展开更多
对不同原边-副边线圈组合所构成的无线电能传输系统,计算原边线圈参数对所激励的均匀磁场的影响,获得生物安全性约束下的安匝数条件;计算电能传输效率和传输功率,获得传输功率对应的设计要求;从提高空间利用率出发,优化副边线圈参数后,...对不同原边-副边线圈组合所构成的无线电能传输系统,计算原边线圈参数对所激励的均匀磁场的影响,获得生物安全性约束下的安匝数条件;计算电能传输效率和传输功率,获得传输功率对应的设计要求;从提高空间利用率出发,优化副边线圈参数后,比较了不同组合的传输效率、传输稳定性。实验表明:三维原边-单维副边的无线电能传输模块能在Φ12×13 mm的空间内提供不小于420 m W,传输效率不小于9.38%,传输稳定度为21.6%,优于其它组合。展开更多
文摘AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.
文摘对不同原边-副边线圈组合所构成的无线电能传输系统,计算原边线圈参数对所激励的均匀磁场的影响,获得生物安全性约束下的安匝数条件;计算电能传输效率和传输功率,获得传输功率对应的设计要求;从提高空间利用率出发,优化副边线圈参数后,比较了不同组合的传输效率、传输稳定性。实验表明:三维原边-单维副边的无线电能传输模块能在Φ12×13 mm的空间内提供不小于420 m W,传输效率不小于9.38%,传输稳定度为21.6%,优于其它组合。
