AIM: To study the clinical and laboratory characteristics of autoimmune hepatitis (AIH), and compare them with International Autoimmune Hepatitis Group (IAHG) criteria. METHODS: Sixty consecutive patients with AIH att...AIM: To study the clinical and laboratory characteristics of autoimmune hepatitis (AIH), and compare them with International Autoimmune Hepatitis Group (IAHG) criteria. METHODS: Sixty consecutive patients with AIH attended the University Clinic at Tabriz University of Medical Sciences, Iran for a 12mo period and were assessed in a case series study. Serological and biochemical evaluations were carried out in all patients. Autoantibodies, such as antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver-kidney microsomal antibody (ALKM-1) type 1, and perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) were evaluated in these patients. A liver biopsy was performed after diagnosis of the disease. Patients were evaluated in terms of their signs and symptoms, and laboratory results and the degree to which they corresponded with the diagnostic criteria of IAHG. In this study, both a comprehensive diagnostic scoring system and a simplified diagnostic scoring system were employed for AIH.RESULTS: Sixty patients, 2-0 male, 40 female, mean age 39.45 ± 17.50 years, participated in the study. Treatment began immediately after enrolment into the study. The percent distribution of the study population into definite and probable did not change after the treatment. The most common symptoms in descending order were fatigue (100%), icter (66.7%), abdominal discomfort (33.3%), abdominal distension (2-8.3%), dark urine (2-3.3%), edema (2-3.3%), hematemesis (2-0.0%), pruritus (2-0.0%), melena (11.7%) and pale stool (10.0%). At the physical examination, splenomegaly, ascites, hepatomegaly, epigastric tenderness and an abdominal mass were found in 50.0%, 16.7%, 13.3%, 5.0% and 3.3% of patients, respectively. Hypergammaglobulinemia was detected in 95.0% of cases. ALKM-1, P-ANCA, ANA and ASMA were positive in 71.4%, 66.7%, 42-.4% and 19.4% of cases, respectively. Portal hypertensive gastropathy (45.0%), esophageal varices (41.7%) and cirrhosis (40.0%) were the most prevalent complications of AIH, and there was n展开更多
《国际儿童风湿病试验组织(PRINTO)幼年特发性关节炎新分类标准专家共识(启动步骤)》于2018年10月发表于Journal of Rheumatology,随后在2018年美国风湿病学会(ACR)年会上,相关专家在大会上进行了介绍。在西方国家,这一新的幼年特发性...《国际儿童风湿病试验组织(PRINTO)幼年特发性关节炎新分类标准专家共识(启动步骤)》于2018年10月发表于Journal of Rheumatology,随后在2018年美国风湿病学会(ACR)年会上,相关专家在大会上进行了介绍。在西方国家,这一新的幼年特发性关节炎(JIA)分类标准还在完善中,PRINTO设计了2步前瞻性研究,完成后将形成成熟的JIA新的分类标准。这一学科的新动向及进展对JIA的诊治及研究具有重大意义。中国儿童免疫与健康联盟组织了部分中国专家对这一国际共识进行解读,旨在对JIA新分类提出中国专家的建议观点,并为我国以后JIA相关真实世界研究提供依据,为与国际新标准接轨提出中国专家的意见。该文仅进行忠实于英文原文的解读,JIA新的分类标准在我国的形成及运用还需要进一步研究及探讨。展开更多
Built Environment and Energy Application Engineering(BEEAE),namely Heating,Ventilating,Air Conditioning and Refrigerating(HVAC&R),is one of the international accreditation programs.Its knowledge system of professi...Built Environment and Energy Application Engineering(BEEAE),namely Heating,Ventilating,Air Conditioning and Refrigerating(HVAC&R),is one of the international accreditation programs.Its knowledge system of professional theory and professional education in accredited engineering academic programs must meet the requirements of the relevant international engineering certification.In view of professional engineers and technicians training of BEEAE,the professional training programs and the knowledge system are compared and explored in line with the international certification criteria.This study compares the items and requirements of different international certification criteria,and summarizes the experienced methods of education training.The undergraduate education and training programs are then improved in accordance with the requirements from international certification criteria.The BEEAE education training schemes should combine the knowledge system of the national professional guidance standards with the items from international certification criteria.展开更多
文摘AIM: To study the clinical and laboratory characteristics of autoimmune hepatitis (AIH), and compare them with International Autoimmune Hepatitis Group (IAHG) criteria. METHODS: Sixty consecutive patients with AIH attended the University Clinic at Tabriz University of Medical Sciences, Iran for a 12mo period and were assessed in a case series study. Serological and biochemical evaluations were carried out in all patients. Autoantibodies, such as antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver-kidney microsomal antibody (ALKM-1) type 1, and perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) were evaluated in these patients. A liver biopsy was performed after diagnosis of the disease. Patients were evaluated in terms of their signs and symptoms, and laboratory results and the degree to which they corresponded with the diagnostic criteria of IAHG. In this study, both a comprehensive diagnostic scoring system and a simplified diagnostic scoring system were employed for AIH.RESULTS: Sixty patients, 2-0 male, 40 female, mean age 39.45 ± 17.50 years, participated in the study. Treatment began immediately after enrolment into the study. The percent distribution of the study population into definite and probable did not change after the treatment. The most common symptoms in descending order were fatigue (100%), icter (66.7%), abdominal discomfort (33.3%), abdominal distension (2-8.3%), dark urine (2-3.3%), edema (2-3.3%), hematemesis (2-0.0%), pruritus (2-0.0%), melena (11.7%) and pale stool (10.0%). At the physical examination, splenomegaly, ascites, hepatomegaly, epigastric tenderness and an abdominal mass were found in 50.0%, 16.7%, 13.3%, 5.0% and 3.3% of patients, respectively. Hypergammaglobulinemia was detected in 95.0% of cases. ALKM-1, P-ANCA, ANA and ASMA were positive in 71.4%, 66.7%, 42-.4% and 19.4% of cases, respectively. Portal hypertensive gastropathy (45.0%), esophageal varices (41.7%) and cirrhosis (40.0%) were the most prevalent complications of AIH, and there was n
文摘《国际儿童风湿病试验组织(PRINTO)幼年特发性关节炎新分类标准专家共识(启动步骤)》于2018年10月发表于Journal of Rheumatology,随后在2018年美国风湿病学会(ACR)年会上,相关专家在大会上进行了介绍。在西方国家,这一新的幼年特发性关节炎(JIA)分类标准还在完善中,PRINTO设计了2步前瞻性研究,完成后将形成成熟的JIA新的分类标准。这一学科的新动向及进展对JIA的诊治及研究具有重大意义。中国儿童免疫与健康联盟组织了部分中国专家对这一国际共识进行解读,旨在对JIA新分类提出中国专家的建议观点,并为我国以后JIA相关真实世界研究提供依据,为与国际新标准接轨提出中国专家的意见。该文仅进行忠实于英文原文的解读,JIA新的分类标准在我国的形成及运用还需要进一步研究及探讨。
基金“2017 Light of Textiles” China Textile Industry Federation Higher Education Teaching Reform,China(No.2017BKJGLX201)
文摘Built Environment and Energy Application Engineering(BEEAE),namely Heating,Ventilating,Air Conditioning and Refrigerating(HVAC&R),is one of the international accreditation programs.Its knowledge system of professional theory and professional education in accredited engineering academic programs must meet the requirements of the relevant international engineering certification.In view of professional engineers and technicians training of BEEAE,the professional training programs and the knowledge system are compared and explored in line with the international certification criteria.This study compares the items and requirements of different international certification criteria,and summarizes the experienced methods of education training.The undergraduate education and training programs are then improved in accordance with the requirements from international certification criteria.The BEEAE education training schemes should combine the knowledge system of the national professional guidance standards with the items from international certification criteria.
